The influence of basic science, particularly molecular biology, in human and veterinary medicine revolutionized thinking in many aspects and changed fundamentally and creatively the classical strategy for research and prevention of infectious diseases. Genetic engineering and related disciplines have progressed to a remarkable degree over the last decade and now form the keystone supporting medicine. These are strong and efficient instruments for health and disease oriented research and their application gives the opportunity to receive more answers and not only more questions. The prime objective of this book is to create new knowledge within the medical disciplines and inspire colleagues working in this field with the unity and unambiguous importance of this science and its technologies for identifying, clarifying and planning new strategies for curing and preventing disease. This book contains original studies on the molecular biology of animal viruses. Some of the viruses discussed in this book are also hazardous to man. In this light it can be considered as a contribution to modern education on the human infectious diseases. From this point of view the book contains a chapter on Hantaan virus that causes no detectable disease in animals but hemorrhagic fever with renal syndrome has been attributed to infection of humans by this virus.
Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals. Organized by species for in-depth understanding of biology, health, and best care of animals Features the inclusion of chinchillas, quail, and zebra finches as animal models Offers guidance on program and employee management Covers regulations, policies, and laws for laboratory animal management worldwide
A volume in the American College of Laboratory Animal Medicine series, this second edition has over 40% new material, including the addition of six new topics and many others that are completely rewritten. The book comprehensively covers the biological and disease aspects of laboratory animal medicine while examining other aspects such as the biohazards associated with the use of animal experimentation and factors complicating the bioethics of animal research.
American Association of Zoo Veterinarians. Conference
This volume and its companion Nonhuman Primates in Biomedical Research: Biology and Management represent the most comprehensive publications of their type on nonhuman primates. This volume addresses the diseases of nonhuman primates with an emphasis on the etiological factors, clinical signs, diagnostic pathology, therapy, and management. Its companion volume serves as a general reference for those who provide care for these animals and for those who use them in biomedical research.
The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The Mo nographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stu dies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors -strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on Nonhuman Primates, is the eleventh volume of a set pre pared under the sponsorship of the International Life Sciences Institute (ILSI).
With coverage of current issues and emerging trends, Fowler's Zoo and Wild Animal Medicine, Volume 7 provides a comprehensive, all-new reference for the management of zoo and wildlife diseases. A Current Therapy format emphasizes the latest advances in the field, including nutrition, diagnosis, and treatment protocols. Cutting-edge coverage includes topics such as the "One Medicine" concept, laparoscopic surgery in elephants and rhinoceros, amphibian viral diseases, and advanced water quality evaluation for zoos. Editors R. Eric Miller and Murray E. Fowler promote a philosophy of animal conservation, bridging the gap between captive and free-ranging wild animal medicine with chapters contributed by more than 100 international experts. The Current Therapy format focuses on emerging trends, treatment protocols, and diagnostic updates new to the field, providing timely information on the latest advances in zoo and wild animal medicine. Content ranges from drug treatment, nutrition, husbandry, surgery, and imaging to behavioral training. Coverage of species ranges from giraffes, elephants, lions, and orangutans to sea turtles, hellbenders, bats, kakapos, and more. An extensive list of contributors includes recognized authors from around the world, offering expert information with chapters focusing on the latest research and clinical management of captive and free-ranging wild animals. A philosophy of animal conservation helps zoo and wildlife veterinarians fulfill not only the technical aspects of veterinary medicine, but contribute to the overall biological teams needed to rescue many threatened and endangered species from extinction. All content is new, with coverage including coverage of cutting-edge issues such as white-nose disease in bats, updates on Ebola virus in wild great apes, and chytrid fungus in amphibians. Full-color photographs depict external clinical signs for more accurate clinical recognition. Discussions of the "One Medicine" concept include chapters addressing the interface between wildlife, livestock, human, and ecosystem health. New sections cover Edentates, Marsupials, Carnivores, Perrissodactyla, and Camelids. Over 100 new tables provide a quick reference to a wide range of topics. An emphasis on conserving threatened and endangered species globally involves 102 expert authors representing 12 different countries.
Pathology of Wildlife and Zoo Animals is a comprehensive resource that covers the pathology of wildlife and zoo species, including a wide scope of animals, disease types and geographic regions. It is the definitive book for students, biologists, scientists, physicians, veterinary clinicians and pathologists working with non-domestic species in a variety of settings. General chapters include information on performing necropsies, proper techniques to meet the specialized needs of forensic cases, laboratory diagnostics, and an introduction into basic principles of comparative clinical pathology. The taxon-based chapters provide information about disease in related groups of animals and include descriptions of gross and histologic lesions, pathogenesis and diagnostics. For each group of animals, notable, unique gross and microscopic anatomical features are provided to further assist the reader in deciding whether differences from the domestic animal paradigm are "normal." Additional online content, which includes text, images, and whole scanned glass slides of selected conditions, expands the published material resulting in a comprehensive approach to the topic. Presents a single resource for performing necropsies on a variety of taxa, including terrestrial and aquatic vertebrates and invertebrates Describes notable, unique gross and microscopic anatomical variations among species/taxa to assist in understanding normal features, in particular those that can be mistaken as being abnormal Provides consistent organization of chapters with descriptions of unique anatomic features, common non-infectious and infectious diseases following brief overviews of the taxonomic group Contains full-color, high quality illustrations of diseases Links to a large online library of scanned slides related to topics in the book that illustrate important histologic findings
New epidemics such as AIDS and "mad cow" disease have dramatized the need to explore the factors underlying rapid viral evolution and emerging viruses. This comprehensive volume is the first to describe this multifaceted new field. It places viral evolution and emergence in a historical context, describes the interaction of viruses with hosts, and details the advances in molecular biology and epidemiology that have provided the tools necessary to track developing viral epidemics and to detect new viruses far more successfully than could be done in the recent past. This unique book also lucidly details case histories and offers practical suggestions for the prevention of future epidemics. The contributors are leading authorities in their disciplines, and were selected both for their expert knowledge and for their ability to define and elucidate the fundamental issues. The book is highly accessible and has been written for a wide audience that includes virologists, public health authorities, medical anthropologists, evolutionary biologists, geneticists, infectious disease specialists, and social scientists interested in medical and health issues.
My lifetime encompasses the postwar subsidence in the early 1920s of the greatest influenza pandemic in history, direct encounters with FM1 virus at Fort Mon mouth in 1947, the care of influenza patients in the 1950s, the pursuit of the in fluenza virus through the modern pandemics of 1957 and 1968, and a present in which the genes of the virus have dissembled in the DNA of vaccinia virus and Escherichia coli through the wand of "high tech. " If my corpus could be fossilized for archival and archaeological purposes, it would be found to contain immune cells branded with the imprint of the "swine" influenza virus of post-1918 and brain cells no less imprinted with memories of the abortive return of its descendant during America's bicentennial. But before that unlikely event, I wanted to try to make some sense out of this baffling dis ease and its viruses-expecting no definitive revelations but hoping for a sharper definition of problems. Hence this book. It is an audacious act in these days of specialization to essay a book such as this singlehandedly, but I have done so for selfish reasons. I wanted to reexam ine old questions about the nature of influenza and its epidemics in the light of the dazzling advances in molecular biology of the past few years. No virus has been better studied, but few diseases are less well understood.
A New York Times bestseller The definitive account of the infectious diseases threatening humanity by Pulitzer Prize–winning investigative journalist Laurie Garrett "Prodigiously researched . . . A frightening vision of the future and a deeply unsettling one." —Michiko Kakutani, The New York Times After decades spent assuming that the conquest of infectious disease was imminent, people on all continents now find themselves besieged by AIDS, drug-resistant tuberculosis, cholera that defies chlorine water treatment, and exotic viruses that can kill in a matter of hours. Relying on extensive interviews with leading experts in virology, molecular biology, disease ecology, and medicine, as well as field research in sub-Saharan Africa, Western Europe, Central America, and the United States, Laurie Garrett's The Coming Plague takes readers from the savannas of eastern Bolivia to the rain forests of the northern Democratic Republic of the Congo on a harrowing, fifty year journey through the history of our battles with microbes. This book is a work of investigative reportage like no other and a wake-up call to a world that has become complacent in the face of infectious disease—one that offers a sobering and prescient warning about the dangers of ignoring the coming plague.