Vascular Liver Disease: Mechanisms and Management covers all of the disease entities that stem from abnormalities that affect the hepatic vasculature. This multi-authored text includes the mechanisms and management of intrahepatic vascular disease, including the most common cause of vascular disease of the liver, cirrhosis. Other less common diseases of the liver vasculature are also covered such as sinusoidal obstruction syndrome (previously known as veno-occlusive disease), portal vein thrombosis, the Budd-Chiari syndrome and congenital vascular malformations. These entities, although rare, are a challenge to physicians and physician scientists. Although many textbooks have been written on the consequences of cirrhosis on the liver vasculature, this is the only volume that focuses on the liver vasculature as a separate entity, providing an innovative approach to liver disease management. Vascular Liver Disease: Mechanisms and Management will be of great value to clinical investigators and basic scientists interested in the liver circulation as well as clinical gastroenterologists and hepatologists, hepatobiliary surgeons and transplant surgeons, and to interventional radiologists with a particular interest in the liver.
A new, fully updated edition of the world’s most famous book on liver diseases—with updating of all areas and inclusion of new specific topics, by internationally renowned specialists This brand new edition of the classic book on hepatology provides a concise, clearly presented and well-structured review across the whole spectrum of hepatobiliary diseases by some of the world’s leading hepatologists and hepatobiliary specialists. Where many other hepatology textbooks provide detailed accounts of basic science and clinical management, Sherlock's Diseases of the Liver and Biliary System, 13th Edition takes a different approach. Concentrating on the clinical decisions to be taken and the relevant supporting data, it is written and edited to maintain Sheila Sherlock's unique approach, in particular the clarity and layout of the text, and the explanatory figures and tables. The book is thus concise, highly accessible, and generously illustrated with over 700 attractive color figures. There is a pithy approach to each disease based both on evidence and on the authors’ experience, the hallmark of this book. Based on these elements, the 12th edition was awarded first prize in the 2012 British Medical Association Book Awards in the Internal Medicine category. Sherlock's Diseases of the Liver and Biliary System begins by introducing the anatomy and function of the liver to readers, continuing then with in-depth coverage of liver biopsy techniques and interpretation, and fibrogenesis and its assessment. There are then chapters on all aspects of liver and biliary disease including acute liver failure, cirrhosis, portal hypertension, hepatic encephalopathy, ascites, hepatitis B and C, alcohol and the liver, non-alcoholic fatty liver disease, drug related liver reactions, cholestatic, autoimmune and genetic liver diseases, benign and malignant tumours and not least liver transplantation. There are also chapters on the liver in pregnancy, in the neonate, infancy and childhood, in systemic diseases and in infections. This new edition also features four new individual chapters focusing on coagulation, non-invasive assessment of fibrosis and cirrhosis; vascular diseases of the liver and portal vein thrombosis, and nutrition in liver disease. Digital downloads of the figures from this edition are offered on a companion website. Internationally recognized and loved, world-renowned hepatology book, first published in 1955 Takes a one-of-a-kind, clinical approach maintaining Sheila Sherlock’s clarity and legacy of presentation Full colour throughout with 700 illustrative figures Wide faculty of international contributors Sherlock's Diseases of the Liver and Biliary System, 13th Edition is an ideal primer in hepatology for students and trainees in hepatology and gastroenterology, and a valuable resource for all specialist gastroenterologists and hepatologists, paediatricians, pathologists, radiologists, general physicians and specialist nurses.
This book offers a systematic introduction to Budd-Chiari syndrome, a rare but life-threatening vascular disorder of the liver, which refers to obstructions at any site from the hepatic veins to the suprahepatic inferior vena cava. The book mainly covers the history, epidemiology, etiology and risk factors, pathology, diagnosis, pharmacological and interventional aspects, surgical treatment, etiological treatment, and prognostic assessment of Budd-Chiari syndrome. Notably, it also presents cutting-edge research findings in this field. The early diagnosis of Budd-Chiari syndrome is vital, as it allows clinicians to pursue more targeted and effective treatment strategies, thus improving patient outcomes. However, much information, including the latest advances, has not yet been fully disseminated in current clinical practice. This book addresses that gap, helping physicians to improve diagnosis and establish standard treatment strategies, helping researchers conduct clinical and experimental studies, and even helping patients and their relatives to recognize this disease.
The Handbook of Liver Disease, 3rd Edition, by Drs. Lawrence S. Friedman and Emmet B. Keeffe, gives you quick reference to the most recent diagnostic and treatment options for patients with liver disorders. International authorities share the latest clinical findings and procedures to help you expertly manage illnesses like hepatitis B and C and hepatocellular carcinoma, as well as apply new practices like genetic testing, noninvasive imaging techniques, and so much more. Quickly access updated information on all aspects of liver disease including new drugs, therapy trials, and post-transplant conditions with this full-color, templated edition-in print and online at www.expertconsult.com. Expedite diagnostic and therapeutic decision making with a highly templated outline format that uses full-color illustrations, tables, algorithms and figures, key point boxes, and alert symbols to present information at a glance. Apply some of the latest treatments for liver disease including the role of pretreatment IL28B testing for patients with hepatitis B and C; radiofrequency ablation and sorafenib in cases of hepatocellular carcinoma; the use of the drug rifaximin to treat hepatic encephalopathy; and much more. Make optimal use of genetic testing to assess your patients' risk of metabolic liver disease and to personalize treatment regimens for chronic hepatitis C. Offer your liver transplantation patients the best prognosis and follow-up with the latest information on outcomes and the management of complications. Use blood test panels and noninvasive imaging techniques to evaluate the degree of liver fibrosis. Make informed treatment decisions with the latest clinical trial results for portal hypertension, autoimmune liver diseases, acute liver failure, and hepatic infections. Search the complete text online, download all the images, and test your knowledge with 200 board-style review questions at www.expertconsult.com. Quick access and easy-to-find answers for any practitioner who encounters patients with liver disease.
New to This Edition Access the complete, fully searchable contents of the book online at www.expertconsult.com, along with a downloadable image bank and complete list of references. Stay current on new developments in the field through five new chapters on Pathogenesis Liver Injury in HBV, HCV; HCC; Imaging and Non-Invasive DX Liver Disease CT, US, Fibroscan, MRI; HIV Co-Infection Drug Toxicity; and HBC, HCV in Non-Liver Transplant Patients, plus comprehensive updates throughout. Apply best practices with reorganized and updated content that reflects today's need for a more clinical approach to hepatology. Reference key information more easily thanks to streamlined content that now fits into one volume.
Concise coverage of all the latest information in gastroenterology and hepatology is set forth in lively question-and-answer format in this new edition, including disorders of the esophagus, stomach, liver and biliary tract, pancreas, small and large bowel. Other sections include multisystem manifestations of GI disease, gastrointestinal radiology, and surgery of the GI tract. Profusely illustrated with over 100 illustrations Concise answers with valuable pearls, tips, memory aids, and secrets 85 succinct chapters written by recognized experts Controversies sections in many chapters that highlight the pros and cons of selected procedures and approaches The most important, need to know questions and answers in the proven format of the highly acclaimed Secrets Series.
The Hepatic circulation is unique among vascular beds. The most obvious unique features include the dual vascular supply; the mechanism of intrinsic regulation of the hepatic artery (the hepatic arterial buffer response); the fact that portal blood flow, supplying two thirds of liver blood flow, is not controlled directly by the liver; the fact that 20% of the cardiac output rushes through the most vascularized organ in the body, driven by a pressure gradient of only a few millimeters of mercury; the extremely distensible capacitance and venous resistance sites; the unidirectional acinar blood flow that regulates parenchymal cell metabolic specialization; and the high concentration of macrophagic (Kupffer) cells filtering the blood. The liver is the only organ reported to have regional blood flow monitored by the autonomic nervous system. This mechanism, when dysfunctional, accounts for the hepatorenal syndrome and offers a mechanistic therapeutic target to treat this syndrome. The trigger for liver regeneration is dependent on hepatic hemodynamics so that chronic liver blood flow regulates liver cell mass. In severe liver disease, the whole body circulation is reorganized, by forming portacaval shunts, to accommodate the increased intrahepatic venous resistance. These shunts protect the venous drainage of the splanchnic organs but lead to loss of major regulatory roles of the liver. The development of knowledge of the hepatic vasculature is presented from a historical perspective with modern concepts summarized based on the perspective of the author's four decades of devotion to this most marvelous of organs. Table of Contents: Acknowledgements / Historical Perspectives / Overview / Fluid Exchange / Capacitance / Resistance in the Hepatic Artery / Resistance in the Venous System / Fetal and Neonatal Hepatic Circulation / In Vivo Pharmacodynamic Approaches / Nitric Oxide / Adenosine / Hepatic Nerves / Hepatic Circulation and Toxicology / Hepatorenal Syndrome / Integrative Hepatic Response to Hemorrhage / Blood Flow Regulation of Hepatocyte Proliferation / Multiple Mechanisms Maintaining a Constant Hepatic Blood Flow to Liver Mass Ratio / Pathopharmacology and Repurposing Drugs as a Research Strategy / References
This new second edition discusses topics important to treatment of peripheral vascular disease, including atherosclerosis, coagulation, vasospastic disease, venous disease, and diseases of the lymphatics. New chapters cover angiography, heritable diseasesof connective tissue, and vascular diseases of infancy and childhood. The atherosclerosis chapter has been revised to include practical advice on patients that are appropriate for interventional therapy and surgery, and it provides a more detailed discussion of circulation-enhancing drugs.
This book presents the full spectrum of vascular diagnostic techniques and vascular and non-vascular interventional procedures performed today. Provides a section on vascular diagnosis and intervention that details each of the major vascular systems and a non-vascular interventional section that covers the main interventional techniques in current use. Each chapter features an easy-to-follow outline of chapter table of contents, normal and variant anatomy, diagnostic entities and interventional procedures. Contains over 1100 helpful illustrations! Helps readers perform complex procedures with detailed guidance and step-by-step illustrations. Emphasizes the pathogenesis, clinical features, and imaging approach and findings of common and uncommon disorders. Discusses the role of non-invasive studies in the evaluation of many disorders. Details surgical and medical alternatives to interventional procedures. Helps readers choose the best possible approaches for their patients with a focus on patient selection, expected outcomes, and comparisons with other treatment modalities. Highlights emerging concepts and current controversies in the field. Organizes coverage by clinical condition to reflect the way cases present in practice. Includes tables of differential diagnoses and common pitfalls, plus clinical pearls, to help readers interpret angiograms accurately. Serves as a comprehensive review for written or oral board exams. Makes further reading easier with selected, up-to-date references.
The Requisites in Gastroenterology series clearly and succinctly encompasses all of the core knowledge in the field. This third volume covers the diagnosis and management of disorders of the hepatobiliary tract and pancreas, discussing pitfalls and presenting evidence-based perspectives throughout. A concise, user-friendly format-with at-a-glance illustrations, boxes, and tables-enables readers to access information quickly. The result is an outstanding resource both for certification and recertification review and for clinical reference. Focuses on exactly what readers need to know for certification-no more, no less. Uses algorithms, tables, and boxes to clarify key facts and concepts. Each chapter begins with a contents list for easy & quick reference. Offers practice-proven, authoritative guidance from established experts.