The Pathology of the Endocrine Pancreas in Diabetes

Author: Pierre J. Lefebvre

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 336

View: 770

Diabetes mellitus represents one of the most frequent and serious clinical syn dromes in contemporary medicine. Since the end of the nineteenth century, the endocrine pancreas has been implicated in the pathogenesis of this disease. Several pathologists of the twentieth century detected various lesions and mor phologic alterations in the pancreatic islets of diabetic patients, but the patho physiologic basis of their findings remained long obscure. The systematic mi croscopic work of WILLY GEPTS clarified the views and related the variety in histopathology to differences in origin, duration and clinical expression of the disease. Over the past two decades, the concept of a multifactorial origin of diabetes has become widely accepted. Various agents and mechanisms have been identified which can lead to a quantitative or qualitative deficit in pancre atic B-cells. The purpose of this book is to bring an update on the many path ways which may induce an absolute or relative insufficiency in insulin release and hence a diabetic state. Rather than bringing a complete account on all re search relevant to the understanding of the pathology of the diabetic pancreas, the authors of the various chapters of this volume have focussed on selected processes which can impair B-cell function, survival or regeneration.

The Pathology of the Endocrine Pancreas in Diabetes

Author: Pierre J. Lefebvre

Publisher: Springer

ISBN:

Category: Medical

Page: 336

View: 697

Diabetes mellitus represents one of the most frequent and serious clinical syn dromes in contemporary medicine. Since the end of the nineteenth century, the endocrine pancreas has been implicated in the pathogenesis of this disease. Several pathologists of the twentieth century detected various lesions and mor phologic alterations in the pancreatic islets of diabetic patients, but the patho physiologic basis of their findings remained long obscure. The systematic mi croscopic work of WILLY GEPTS clarified the views and related the variety in histopathology to differences in origin, duration and clinical expression of the disease. Over the past two decades, the concept of a multifactorial origin of diabetes has become widely accepted. Various agents and mechanisms have been identified which can lead to a quantitative or qualitative deficit in pancre atic B-cells. The purpose of this book is to bring an update on the many path ways which may induce an absolute or relative insufficiency in insulin release and hence a diabetic state. Rather than bringing a complete account on all re search relevant to the understanding of the pathology of the diabetic pancreas, the authors of the various chapters of this volume have focussed on selected processes which can impair B-cell function, survival or regeneration.

The Diabetic Pancreas

Author: Bruno W. Volk

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 628

View: 776

Since the publication of the first edition of The Diabetic Pancreas in 1977, much progress has been made in various areas of diabetes research. While only a rela tively short while ago diabetes was considered a single disease, in more recent years it has become apparent that it is a heterogeneous group of disorders, all of which are characterized by a decreased tolerance of carbohydrates and most of which have a genetic basis, although the genetic types vary. In more recent years, an International Work Group sponsored by the National Diabetes Data Group of the NIH proposed a now generally accepted classification, according to which the insulin-dependent ketosis-prone diabetes, formerly and inappropriately called the juvenile type, is considered a subclass of diabetes, type 1. Because it can occur at any age, it was recommended that the diagnosis based on age be eliminated. The non-insulin-dependent, non-keto sis-prone type of diabetes, which is not secondary to other diseases or conditions, and which was formerly called matu rity-onset diabetes, was considered a second subclass, type II, because although this form usually develops after age 40, it also occurs in young persons, who do not require insulin or are not ketotic. Although this classification is not entirely agreed upon by all diabetologists, for practical purposes it has been generally accepted and has been utilized by the contributors to this volume.

Clinical Pathology of Pancreatic Disorders

Author: John A. Lott

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 232

View: 919

The pancreas is about the size and shape of the hand; the tail points to the spleen, and the head is nestled in a loop of the duodenum. Loss of the exocrine (digestive) func tions commonly leads to severe gastrointestinal disturbances, malabsorption, a cata bolic state, and weight loss in the face of an adequate diet. Loss of endocrine pancreatic function leads to a large spectrum of disorders associated with the loss of hormone secretions; the most common and most severe is diabetes mellitus. Loss of the entire pancreas owing to trauma, surgery, atherosclerosis, or other medical problems leaves the patient in a digestive and metabolic crisis. The correct diagnosis of pancreatic disorders remains a challenge given the multi faceted function of the pancreas. The clinical laboratory plays an important role, and other tools such as CAT scans, ultrasound, radiographs, biopsies, and even surgery are used to make a diagnosis. The emphasis of Clinical Pathology of Pancreatic Disorders is on the clinical laboratory definition of pancreatic pathology. Disorders of the endocrine pancreas can be highly complex, and sophisticated tests are needed to determine the nature of the disease, its prognosis, and its optimal treat ment. Diabetes is the most common of the endocrine diseases; it presents in many ways, and has varied etiologies. We now know that the diabetes of childhood is usually an autoimmune disease, and this has a major effect on the treatment of these individuals.

Endocrine Pathology:

Differential Diagnosis and Molecular Advances

Author: Ricardo V. Lloyd

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 607

View: 949

Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition provides detailed coverage of endocrine pathology with extensive discussion of the differential diagnosis as well as presentation of molecular pathobiology of the major endocrine organs. Revised and expanded from the first edition, each chapter, written by leaders in their respective field, has been updated with the latest advances that are transforming the field of endocrine pathology. Richly illustrated with color photomicrographs, useful diagrams and line drawings, each chapter includes differential diagnosis of common and uncommon lesions as well as material on molecular developments, with emphasis on the molecular findings that are most helpful in the diagnosis of specific disorders. Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition, provides a useful and well-organized resource designed not only for the endocrine pathologist and the general surgical pathologist, but also for the clinical endocrinologist and the endocrine surgeon.

Pathology of the Pancreas, Gallbladder, Extrahepatic Biliary Tract, and Ampullary Region

Author: Ernest E. Lack

Publisher: Oxford University Press

ISBN:

Category: Medical

Page: 608

View: 137

As a single comprehensive reference source and full-color atlas, this book covers a wide range of pathology. Normal anatomy as well as developmental abnormalities are detailed. A variety of non-neoplastic conditions are covered, including transplant pathology, diabetes mellitus and pancreatitis. Neoplasms are emphasized. The difficulties encountered with frozen section diagnosis, cytopathology, and tumor classification systems are addressed. Common and rare conditions of pancreas, gallbladder, extrahepatic biliary tract and ampullary regions are all extensively reviewed. Special attention is paid to clinical features, prognostic factors, biologic behavior and survival. With almost 1,300 color images and over 5,300 references, this treatise is a major contribution to field.

Diabetes Mellitus: Pathophysiology and Therapy

Bayer AG Centenary Symposium Edinburgh, U.K., May 25–28, 1988

Author: Werner Creutzfeldt

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 354

View: 587

This book contains the reviews delivered at the Bayer Centenary Symposium held in Edinburg in May 1988. Experts in the field reported on recent developments in the pathophysiology and therapy of diabetes mellitus. Thus an up-to-date overview of diabetes mellitus research presented to a small group of specialists is now available to a broader community of endocrinologists, physicians and internists.

Handbook of Toxicologic Pathology

Author: Wanda M. Haschek

Publisher: Elsevier

ISBN:

Category: Medical

Page: 1127

View: 507

This is the first comprehensive reference work on toxicologic pathology, an emerging field that integrates the mechanisms of toxic injury with the resulting pathology. Chapters deal systematically with organ-specific toxic injury, describing the mechanisms of injury, morphological expression of the injury, and evaluation of the pathology. Additional chapters introduce the field to the uninitiated and address such topics as techniques used for morphological evaluation, risk assessment, and regulatory aspects. The Handbook of Toxicologic Pathology will quickly establish itself as the classic reference work in this field for years to come. Comprehensive, "user friendly" reference text on toxicologic pathology Large, easy-to-use 8 1/2" x 11", double-column format Systematic approach to each organ or system More than 500 illustrations and 90 tables complement the text Over 2,000 references for easy access to the primary literature Unique chapters written by leading authorities

Pathology of the Pancreas

Author: Alan H. Cruickshank

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 341

View: 257

Derived from 40 years' experience in diagnostic surgical pathology and autopsy rooms, this book deals with the gross and microscopic structure of the normal pancreas, placing a special focus on structural abnormalities. Updated information on congenital abnormalities and the effects of primarily non-pancreatic diseases upon this organ such as arterial diseases, makes this new Second Edition a indispensable addition to your library.