Incorporating the most important advances in the fast-growing field of cancer biology, the text maintains all of its hallmark features. It is admired by students, instructors, researchers, and clinicians around the world for its clear writing, extensive full-color art program, and numerous pedagogical features.
Advances in research and the treatment of cancer mean that more patients and their carers are asking healthcare professionals about the latest treatments and how they may be of benefit. It is essential that staff working with cancer patients understand fully how these new treatments work in order to disseminate timely and appropriate information to patients. The application of biology to the delivery of cancer care is playing an ever-increasing role in the management of these diseases. The Biology of Cancer: Second Edition provides details of the most recent developments in cancer care and is divided into three sections: Understanding Cancer – examines predisposing factors to developing cancer, diagnosis and its implications on the individual and society. The Science of Cancer – a closer look at the cell, genetics, the immune system, tumour markers and monoclonal antibodies. Research and Treatment – exploring translational oncology, applying research methodology to cancer research and research ethics relating to cancer. This fully updated edition also looks at evidence-based research that can be translated directly to patient care and gives details recent developments. Written by experienced, practicing healthcare professionals, The Biology of Cancer: Second Edition can easily be applied to patient care. It is an informative text for students, newly qualified nurses and practising oncology/palliative care nurses.
Molecular Biology of Cancer has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. It continues to provide a detailed overview of the process which lead to the development and proliferation of cancer cells, including the techniques available for their study. It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer.
This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. Written by an international panel of researchers, specialists and practitioners in the field Covers both traditional areas of study and areas of controversy and emerging importance, highlighting future directions for research Features up-to-date coverage of recent studies and discoveries, as well as a solid grounding in the key concepts in the field Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review Supported by a dedicated website at www.blackwellpublishing.com/pelengaris An excellent text for upper-level courses in the biology of cancer, for medical students and qualified practitioners preparing for higher exams, and for researchers and teachers in the field
Biology is the natural science that studies life and living organisms, including their physical structure, chemical processes, molecular interactions, physiological mechanisms, development and evolution. This book provides over 2,000 Exam Prep questions and answers to accompany the text The Biology of Cancer Items include highly probable exam items: DNA sequencing, nomenclature, eukaryotic, Thrombin, Threonine, SnRNP, Nitrogen, Helix, Dystrophin, Protein structure, nomenclature, hydrogen, and more.
Of all the diseases that afflict mankind those described as 'cancer' evoke the strongest emotions. 'Cancer' connotes pain, protracted suffering, hideous growth and death. It is widely and justifiably feared. In medically advanced countries, malignant neoplasms (the official term for cancers) account for a substantial proportion of all deaths. Out of a total of 575194 deaths in Eng land and Wales during the year 1970, some 117076-or 20·4 per cent-were attributed to neoplasms of one kind or another (Registrar General, 1972). Diseases of the circulatory system-mainly arteriosclerotic and degenerative heart disease-claimed many more victims, being responsible for some 50·6 per cent of all deaths, but our psyche evidently responds more to the manner of the disease than to the number of deaths it causes. Many of us will have witnessed the deterioration of a close friend or relative suffering from an inoperable cancer: such an experience induces a sense of hopelessness and helplessness. The feelings of sorrow and distress can be a powerful stimulus to action and they often result in dedicated and tireless research efforts. At the same time, the very strength and depth of the commitment may sometimes be incompatible with the detachment that is needed for objective analysis and a wise strategy. Not too rigorously, we reason that if only we can discover the causes of cancer, then our problems will be solved and our agonies relieved. Remove the cause: prevent the cancer. The logic exerts an irresistible appeal.
The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.