Polymeric Drugs and Drug Delivery Systems

Author: Raphael M Ottenbrite

Publisher: CRC Press

ISBN:

Category:

Page: 328

View: 443

Polymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume consists of twenty-two recent research-based reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports were prepared by top scientists in the field and are based on current research conducted at leading laboratories in the U.S.A., Europe, and Asia. These 22 chapters report the latest information in the application of polymers to biological systems.

Polymers in Drug Delivery

Author: Ijeoma F Uchegbu

Publisher: CRC Press

ISBN:

Category:

Page: 276

View: 562

Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene therapy. While Polymers in Drug Delivery offers much new insight for the veteran specialist, this work has been compiled with the non-specialist in mind. It includes contributions from many of the world's leading drug delivery specialists, yet avoids jargon and presents background information that initiates the next generation of scientists into the amazing work going on at the frontiers of this rapidly evolving science. Targeting specific issues at the forefront of drug delivery today, this engaging volume-- - Outlines the issues that must be considered when selecting a polymer for fabricating a drug delivery agent or other medical devices - Explains the more commonly used methods by which polymers may be characterized prior to use - Profiles polymer matrices that have been used in the formulation of solid oral dosage forms, drug delivery scaffolds, and hydrogels - Examines the issues surrounding the encapsulation of biologics within microspheres - Explores the use of nanoparticulates, especially solid nanoparticles and nanocapsules prepared from largely-water-insoluble cyanoacrylate polymers - Discusses polymeric micelles and investigates the potential of soluble polymer prodrugs and polymer nanomedicines - Details the contribution made by polymers and de

Pharmaceutical Applications of Polymers for Drug Delivery

Author: David Jones

Publisher: iSmithers Rapra Publishing

ISBN:

Category: Science

Page: 124

View: 421

Annotation The review focuses on the use of pharmaceutical polymer for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined and applications of polymers for controlled drug delivery are described. The field of controlled drug delivery is vast therefore this review aims to provide an overview of the applications of pharmaceutical polymers. The review is accompanied by approximately 250 abstracts taken from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject.

Engineering Polymer Systems for Improved Drug Delivery

Author: Rebecca A. Bader

Publisher: John Wiley & Sons

ISBN:

Category: Social Science

Page: 496

View: 789

Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.

Polymeric Drugs and Drug Delivery Systems

Author: Richard L. Dunn

Publisher: American Chemical Society

ISBN:

Category: MEDICAL

Page: 313

View: 957

Covering a broad spectrum of methods of drug delivery and focusing on the use of polymers and materials, this volume presents new materials and methods for controlled drug release. Emphasizing selection of materials for drug delivery rather than just reviewing current methods, the editors challenge researchers to venture into new areas and consider new methods. Included is an examination of recent advances in biodegradable and bioerodible polymer matices for drug delivery. An introductory section of four tutorial chapters ("Biologically Active Polymers", "Polymeric Matrices", "Liposomes", and "Interactions Between Polymeric Drug Delivery Systems and Biological Systems") will be of great value to those just entering the field.

Polymers for Controlled Drug Delivery

Author: Peter J. Tarcha

Publisher: CRC Press

ISBN:

Category: Medical

Page: 296

View: 517

Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.

Applications of Polymers in Drug Delivery

Author: Ambikanandan Misra

Publisher: Elsevier

ISBN:

Category: Technology & Engineering

Page: 594

View: 140

Applications of Polymers in Drug Delivery, Second Edition, provides a comprehensive resource for anyone looking to understand how polymeric materials can be applied to current, new, and emerging drug delivery applications. Polymers play a crucial role in modulating drug delivery and have been fundamental in the successful development of many novel drug delivery systems. This book describes the development of polymeric systems, ranging from conventional dosage forms to the most recent smart systems. Regulatory and intellectual property aspects as well as the clinical applicability of polymeric drug delivery systems are also discussed. The chapters are organized by specific delivery route, offering methodical and detailed coverage throughout. This second edition has been thoroughly revised to include the latest developments in the field. This is an essential book for researchers, scientists, and advanced students, in polymer science, drug delivery, pharmacology/pharmaceuticals, materials science, tissue engineering, nanomedicine, chemistry, and biology. In industry, this book supports scientists, R&D, and other professionals, working on polymers for drug delivery applications. Explains how polymers can be prepared and utilized for all major drug delivery routes Presents the latest advances, including drug targeting, polymeric micelles and polymersomes, and the delivery of biologicals and nucleic acid therapeutics Includes appendices with in-depth information on pharmaceutical properties of polymers and regulatory aspects

Polymeric Drugs and Drug Delivery Systems

Author: Raphael M. Ottenbrite

Publisher: CRC Press

ISBN:

Category: Science

Page: 328

View: 549

Polymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume consists of twenty-two recent research-based reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports w

Polymers in Drug Delivery

Author: Ijeoma F. Uchegbu

Publisher: CRC Press

ISBN:

Category: Medical

Page: 280

View: 866

Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera

Polymers for Controlled Drug Delivery

Author: Peter J. Tarcha

Publisher: CRC Press

ISBN:

Category:

Page: 296

View: 111

Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.

Advanced Biopolymeric Systems for Drug Delivery

Author: Amit Kumar Nayak

Publisher: Springer Nature

ISBN:

Category: Technology & Engineering

Page: 386

View: 681

This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.

Natural Polymer Drug Delivery Systems

Nanoparticles, Plants, and Algae

Author: Saurabh Bhatia

Publisher: Springer

ISBN:

Category: Technology & Engineering

Page: 225

View: 376

This book describes 200 bio-polymers, including the most recent and advanced nanotechnology applications. The applications of various bio-medical and other future potential uses are covered and examined in depth. Systematic discussion of current leading natural polymers is also included.

Polymeric Drug Delivery

Author: Sönke Svenson

Publisher: Amer Chemical Society

ISBN:

Category: Science

Page: 376

View: 847

Polymeric Drug Delivery: Polymeric Matrices and Drug Particle engineering is designed to bridge the gap between industrial and academic researchers in drug delivery and the pharmaceutical industry because conferences focus one of these two aspects. The book covers three main topics of drug delivery: the use of particulate carriers to transport actives to specific sites within the body, the use of matrices to tailor release rates to drug specific needs, and technologies to engineer drug particles in a way that will improve their bioavailability. Polymeric materials are being used in all three areas, as carriers, matrices, or part of the formulation of drug particles.

Polymeric Drug Delivery Systems

Author: Glen S. Kwon

Publisher: CRC Press

ISBN:

Category: Medical

Page: 680

View: 678

Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.

Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications

Volume 2: Advanced Nanocarriers for Therapeutics

Author: Abdel Salam Hamdy Makhlouf

Publisher: Woodhead Publishing

ISBN:

Category: Technology & Engineering

Page: 637

View: 203

Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications: Volume Two: Advanced Nanocarriers for Therapeutics discusses, in detail, the recent trends in designing dual and multi-responsive polymers and nanoparticles for safe drug delivery. Chapters cover dual-responsive polymeric nanocarriers for drug delivery and their different stimuli, multi-responsive polymeric nanocarriers, and the therapeutic applications of stimuli-responsive polymers. With an emphasis on advanced medical applications and synergistic operational and technological methodologies for the improvement of polymers systems for the production of stimuli-responsive polymers, this book is essential reading for materials scientists and researchers working in the drug delivery and pharmaceutical industries. As innovation and development in the area of stimuli responsive polymer-based nanomaterials for drug delivery is moving fast and there is an increased global demand for biodegradable and biocompatible responsive polymers and nanoparticles for safe drug delivery, users will find this to be a timely resource. Focusses on the most advanced technologies, recent evaluation methods, technical aspects, and advanced synthesis techniques stimuli-responsive polymers Examines advanced medical applications of stimuli responsive polymers Analyzes synergistic operational and technological methodologies for the improvement of polymer systems for the production of stimuli-responsive polymers in drug delivery

Controlled Drug Delivery Systems

Towards New Frontiers in Patient Care

Author: Filippo Rossi

Publisher: Springer

ISBN:

Category: Technology & Engineering

Page: 100

View: 225

This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under- and overdosing.

Advances in Polymeric Systems for Drug Delivery

Author: Raymond Bonnett

Publisher: CRC Press

ISBN:

Category: Technology & Engineering

Page: 149

View: 646

This title examines new drug delivery strategies utilizing intelligent polymeric materials that perform sensing, processing and response functions. The authors demonstrate the design of polymers with integrated intelligent functions to achieve site specific and temporally controlled drug delivery, specifically for pharmaceutical applications. Using stimuli-responsive polymers as molecular devices for self-regulation and externally modulated drug delivery systems are reviewed from multi-disciplinary perspectives, employing materials science and bio-engineering as an important foundation.

Update on Polymers for Pulmonary Drug Delivery

Author: Hugh D. C Smyth

Publisher: Smithers Rapra

ISBN:

Category: Medical

Page: 285

View: 362

Pulmonary drug delivery has been a rapidly expanding field, moving from the traditional propellant based metered dose inhaler delivery of small asthma drugs, to a broader landscape of new devices and novel drugs for local and systemic delivery. The field has greatly expanded yet the tools for pulmonary drug delivery systems have not kept pace with the potential applications. One of the key developments has been the use of polymers to achieve better control of pulmonary drug delivery. This has the potential to expand the toolbox available for researchers in the field to deliver their new chemical entities successfully to the lung. This book reviews the use of polymers in pulmonary drug delivery, encompassing polymers from their use in devices and packaging, in addition to their use as excipients in formulations delivered to the airways. The book is arranged by application and extensively reviews the technical and patent literature. This is the first volume totally dedicated to polymers in pulmonary drug delivery and should be the resource of choice for those in the field, especially managers in the pharma/biotech industry. Naturally, the text will be of great interest to academics and graduate students. Finally, regulatory affiliated scientists will also find this resource invaluable.

Drug Delivery Strategies for Poorly Water-Soluble Drugs

Author: Dionysios Douroumis

Publisher: John Wiley & Sons

ISBN:

Category: Science

Page: 648

View: 591

Many newly proposed drugs suffer from poor water solubility,thus presenting major hurdles in the design of suitableformulations for administration to patients. Consequently, thedevelopment of techniques and materials to overcome these hurdles is a major areaof research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs providesa comprehensive overview of currently used formulation strategiesfor hydrophobic drugs, including liposome formulation, cyclodextrindrug carriers, solid lipid nanoparticles, polymeric drugencapsulation delivery systems, self–microemulsifying drugdelivery systems, nanocrystals, hydrosol colloidal dispersions,microemulsions, solid dispersions, cosolvent use, dendrimers,polymer- drug conjugates, polymeric micelles, and mesoporous silicananoparticles. For each approach the book discusses the maininstrumentation, operation principles and theoretical background,with a focus on critical formulation features and clinical studies. Finally, the bookincludes some recent and novel applications, scale-upconsiderations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is anessential multidisciplinary guide to this important area of drugformulation for researchers in industry and academia working indrug delivery, polymers and biomaterials.