Perfect Targets

Asperger Syndrome and Bullying : Practical Solutions for Surviving the Social World

Author: Rebekah Heinrichs

Publisher: AAPC Publishing

ISBN:

Category: Education

Page: 189

View: 859

Looks at the different types of bullying and the actions adults must take to curb bullying, thereby helping to prevent the often lifelong effects of this insidious form of behavior on victims. This book presents practical strategies and solutions at the school, class and individual level.

Perfect Target

Author: Stephanie Newton

Publisher: Steeple Hill

ISBN:

Category: Fiction

Page: 224

View: 208

The corpse in her path was Bayley Foster's first warning. The second? A break-in at Bayley's own home! She's certain that the stalker who once tormented her has returned to toy with her again. But has her stalker truly escalated to murder? Her fiercely protective neighbor, police detective Cruse Conyers, is determined to get answers. Even if it takes him into the murky depths of the criminal underworld. What he uncovers adds a terrifying twist to the case that could land both Cruse and Bayley in the cross fire….

The Perfect Target

Author: Jenna Mills

Publisher: Silhouette

ISBN:

Category: Fiction

Page: 256

View: 770

All Miranda Carrington wanted was to be free from her legendary family's legacy of wealth and power. But even in a little seaside village in Portugal, she could not escape the danger that shadowed her.... Only the sudden, stunning appearance of a dark, mysterious stranger had saved her from the ruthless terrorists stalking her. But was Allessandro Vellenti really the devoted guardian he claimed, or part of the deadly conspiracy swirling around her? She knew she shouldn't trust him--with her life or with her heart. And yet, as she fled with him, she ached to give herself, body and soul, to this man who could be her killer....

The Mom's Guide to Asperger Syndrome

And Related Disorders

Author: Jan Johnston-Tyler

Publisher: AAPC Publishing

ISBN:

Category: Education

Page: 321

View: 594

he Mom's Guide to Asperger Syndrome and Related Disorders is written primarily for parents of children who have newly been diagnosed with Asperger Syndrome. It is especially a great resource for the preschool through elementary school years. The book draws from the author's personal experience both as the mom of a son with Asperger Syndrome and her study of and work with children and adolescents with special needs. The result is a practical guide, written for other Aspie parents in a clear, concise, and sometimes humorous tone.This user-friendly book leaves no stone unturned, as it explains, in a friendly, familiar voice, situations and issues that all parents with an AS child will encounter at one point or another. Above all else, the book arms parents with basic, sound information empowering them to seek out the very best services and programs for their child.From dealing with sensory issues and bullying to staying on top of homework, The Mom's Guide to Asperger Syndrome and Related Disorders offers easy-to-use suggestions. The Mom's Guide to Asperger Syndrome and related disorders should be used as a practical, valuable reference throughout the years.

A Role for the Let-7 Primary MicroRNA in Target Gene Recognition and Repression

Author:

Publisher: Stanford University

ISBN:

Category:

Page:

View: 758

MicroRNA (miRNA) genes produce three noncoding RNA products: the long primary transcript (pri-miRNA), the ~70 nucleotide pre-miRNA, and the ~22-nt mature miRNA. Only the mature miRNA is considered to be the functional species of a miRNA gene in recognizing cognate target mRNAs and modulating their expression. However, mature miRNAs are processed from the primary transcript through sequential endonucleolytic steps. As a result, the mature miRNA sequence is present in all three RNA products of a miRNA gene. It has thus been intrinsically difficult to determine the contribution of each miRNA gene product to target repression. In fact, direct functional roles for pri- and pre-miRNAs have never been ruled out. Here we show that pri- and pre-miRNAs may not be mere transitory intermediates of mature miRNA biogenesis. We found that ectopic expression of the C. elegans miRNA gene let-7 (cel-let-7) in human culture cells results in the production of truncated pre- and mature miRNAs that lack the first two 5' nucleotides, one of which is the first nucleotide of the miRNA seed region (nucleotide SD1). We found this nucleotide to be required for repression of target reporters by cel-let-7 in these cells, demonstrating that pri-let-7 may have a direct role in target repression. Further, we show that the nucleotide sequence and structure of both the pri-/pre-let-7 loop and stem regions play a key role in miRNA gene function in reporter assays. In vitro and in vivo analyses indicated the significance of these regions may be in the mediation of a physical interaction between pri-let-7 and target RNAs. These observations suggest that regulatory information encoded in the structured pri-miRNAs, but absent from mature miRNAs, could be directly interpreted for target recognition and repression through RNA:RNA interaction. Intriguingly, some mutations in the loop nucleotide sequence also restored processing of the 5' ends of C. elegans pre- and mature let-7 in culture cells, demonstrating that the pri-/pre-miRNA loop region can also regulate the precision of mature miRNA biogenesis. Importantly, in the presence of functional pre- and mature let-7, cel-let-7 activity in target repression consists of both SD1-independent and SD1-dependent components, implying potential contributions by both pri- and mature let-7. Finally, we interrogated the effects of pri-/pre-let-7 loop mutations on their ability to rescue a let-7 loss-of-function mutant phenotype in C. elegans. Our results indicate decreased significance of these parameters in the control of worm vulval development, although context-dependent differences in mature miRNA biogenesis between heterologous culture and live animals may partially explain this discrepancy. Taken together the work presented here reveals a novel layer of regulatory complexity encoded in long primary miRNAs that may have broad implications in understanding the mechanisms by which miRNA genes control target expression.

Soft Target Hardening

Protecting People from Attack

Author: Jennifer Hesterman

Publisher: CRC Press

ISBN:

Category: Computers

Page: 321

View: 187

Winner of ASIS International’s 2015 Security Book of the Year Award Terrorist attacks occur daily and are increasingly being aimed at civilian populations around the world. Battlefield lines have been redrawn to include churches, schools, hospitals, and malls. This breach of moral boundary is shocking and invokes fear—two primary goals of terrorism. Although there is an increase in soft target activity—or attacks on places of worship, study, and leisure—there is hesitation to explore such susceptibility in the United States. Soft Target Hardening: Protecting People from Attack starts the national dialogue by providing case studies, best practices, and methodologies for identifying soft target vulnerabilities and reducing risk in the US. Offering deterrence and mitigation techniques from more than 275 sources, this comprehensive book: Explores US cultural nuances contributing to the country turning a psychological blind eye toward soft target threats Assesses the attractiveness of soft target threats presented by foreign and domestic terror groups and drug trafficking organizations Analyzes the unique vulnerabilities of churches, schools, hospitals, malls, sporting and recreational events, and other soft targets Gives an overview of soft target hardening tactics from global hotspots, including first-person accounts and photographs Introduces the concept of effects-based hardening, derived from the military model of effects-based operations Discusses emerging soft target challenges such as insider threats, kidnapping, and use of human shields Evaluates the likelihood of the use of weapons of mass destruction against civilian-centric venues Soft Target Hardening: Protecting People from Attack is a must-read for those who secure, own, and operate soft target facilities, and for citizens who want to protect themselves and their families from attack.

The Accidental President

Author: Harris I. Baseman

Publisher: iUniverse

ISBN:

Category: Fiction

Page: 336

View: 235

When an explosion rips through the home of Gulf War veteran Clarence Davenport, Secret Service Agent John Wallace and White House aide Molly Pemberton are certain that Davenport, the assassin who killed President Butler, had killed himself. President Silver, the former Education Secretary who became President when Davenport killed all other legal successors to the Presidency, informs the nation that the crime of the century has been solved and that the perpetrator is dead, only to have to admit, days later, that Davenport had escaped. National outrage at Davenport's escape escalates, fueled by Senator Jeb Davies' political ambition and his hatred of Ben Silver. Davenport, the world's most sought after fugitive, with no other place to go, is recruited by Saudi expatriates opposed to the Royal Family and ends up in an Al Qaeda training camp where he devises another plan to kill President Silver and attack the United States. Silver tries to stave off the rising tide of impeachment and at the same time combat the increasing risk of a terrorist attack that will destroy the Presidency and fundamentally change the Unites States unless he can avoid impeachment and intercept the threat. " timely as this evening's news " -Melannie Lauers, Cape Cod Times(on After Kamisiyah) " an intriguing insight " -Mathew Call, Newton Tab (on After Kamisiyah)

Southeastern Geographer

Spring 2012 Issue

Author: David M. Cochran Jr.

Publisher: UNC Press Books

ISBN:

Category: Social Science

Page: 152

View: 800

Table of Contents for Volume 52, Number 1 (Spring 2012) Cover Art A Section of the Kansas City Southern in Hattiesburg, Mississippi David M. Cochran, Jr. Introduction David M. Cochran, Jr. and Carl A. Reese Part I: Papers Spatial and Temporal Variations in West Virginia's Precipitation, 1931–2000 James Leonard and Kevin Law The Gulf of Mexico Red Snapper Individual Fishing Quota Program in Florida: Perceptions and Implications Kamal Alsharif and Nathan Miller Reflections in the Water: Society and Recreational Facilities, a Case Study of Public Swimming Pools in Mississippi P. Caleb Smith Local Food Initiatives in Tobacco Transitions of the Southeastern United States Richard A. Russo A GIS-Based Football Stadium Evacuation Model Joslyn J. Zale and Bandana Kar Part II: Geographical Notes The Origin and Appreciation of Savannah, Georgia's Historic City Squares Louis De Vorsey Part III: Reviews Louisiana Place Names of Indian Origin, A Collection of Words William A. Read, edited by George M. Riser Reviewed by Andy Hilburn The SAGE Handbook of Geographical Knowledge Edited by John Agnew and David N. Livingstone Reviewed by J. O. Joby Bass

Seal Team Seven #20

Attack Mode

Author: Keith Douglass

Publisher: Penguin

ISBN:

Category: Fiction

Page: 304

View: 808

Fifteen-hundred miles west of Hawaii, a freighter is hijacked with enough weapons-grade plutonium onboard to blast all the major capitals of the world into radioactive dust. These pirates are planning to sell the plutonium to countries like Iran for the purpose of developing nuclear warheads, and if there’s any attempt to retake the ship, they are prepared to release their deadly cargo and kill thousands. Only a team of specialists—highly trained to do the armed forces’ most dangerous job—can perform the surgical strike necessary to take out the bad guys. SEAL Team Seven is ready to bring them down.

Sea of Fire

Op-Center 10

Author: Tom Clancy

Publisher: Penguin

ISBN:

Category: Fiction

Page: 400

View: 889

A half-dead Singapore pirate is plucked from the Celebes Sea in the Western Pacific, setting off alarms halfway around the world in Washington, D.C. Traces of radiation are found on the man, causing Australian officials to call in Op-Center for a top-secret investigation of nuclear disposal sites. When an empty drum from a recent drop-off is discovered near where the pirate's ship was destroyed, the Op-Center team comes to a terrifying conclusion: A multinational corporation hired to dispose of nuclear waste is selling it instead-to a most unlikely terrorist...