Opioids in Medicine

A Comprehensive Review on the Mode of Action and the Use of Analgesics in Different Clinical Pain States

Author: Enno Freye

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 472

View: 291

This book fills the void to provide a comprehensive review of the theoretical knowledge and scope of opioid pharmacotherapy in pain medicine. While the information provided is obtainable in other major texts already in print, the present format style plus the illustrations will make easy reading and fast accessibility of information on opioids available. Information provided is based on clinical practice rather than pure experimental for use in daily practice.

Opioids and Pain Relief

A Historical Perspective

Author: Marcia L. Meldrum

Publisher: International Assn for the Study of Pain

ISBN:

Category: Medical

Page: 248

View: 170

Presents 14 papers from the second conference sponsored by the John C. Liebeskind History of Pain Collection (held in August of 2000). The conference brought together scientists and historians in order to examine the history of the opioids--opium, morphine, heroin, and others--as a "Janus drug," showing two faces of therapeutics on the one hand and addiction and degradation on the other. The focus is on the use of opioids within medicine and the growth of scientific understanding about them and their impact on human beings.

Regional Opioid Analgesia

Physiopharmacological Basis, Drugs, Equipment and Clinical Application

Author: J. de Castro

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 640

View: 758

by E.K. ZSIGMOND, M.D. Department of Anesthesiology University of Illinois Chicago U.S.A. It is, indeed, a distinct honor and privilege to be invited by the authors to write a preface to this monumental monograph, Regional Opioid Analgesia. Regional Opioid Analgesia is a colossal undertaking by Drs. De Castro, Meynadier and Zenz shortly after the introduction of this revolutionary approach to pain relief which opened a new epoch in analgesiology. This is, indeed, the first authentic and comprehensive textbook encompassing the current knowl edge on this novel approach to pain relief. We are indebted to the authors for introducing the new opioids to regional analgesia with the scientists, who de veloped the potent short and ultrashort acting opioids with high therapeutic indices, which many researchers dreamt about but never before materialized. The side effect liabilities of these new opioids are minute as compared to morphine and meperidine. Regional Opioid Analgesia could not have been more authentically written than by Drs. De Castro,Zenz and Meynadier,who have conducted daily clinical investigations on all known opioids for regional analgesia as well as for neurolept analgesia. Therein lies the great value of this monograph: it is the most authentic work on this topic.

Pain Management and the Opioid Epidemic

Balancing Societal and Individual Benefits and Risks of Prescription Opioid Use

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

ISBN:

Category: Medical

Page: 482

View: 234

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Opioids

Use and Abuse

Author: J. Levy

Publisher:

ISBN:

Category: Drug addiction

Page: 72

View: 865

Treating Opioid Use Disorder in General Medical Settings

Author: Sarah E. Wakeman

Publisher: Springer Nature

ISBN:

Category: Medical

Page: 242

View: 396

This book is an invaluable reference for medical practitioners seeking to integrate opioid use disorder (OUD) treatment into general medical settings, including primary care, the inpatient hospital, and the emergency department. It recognizes opioid-related deaths in the United States as a significant public health crisis and fills the gap in drug use and addiction treatment knowledge for care providers. Timely and concise, opening chapters examine the history of OUD pharmacology and treatment, as well as the principles of care and treatment. Subsequent chapters analyze the shortcomings of current approaches to opioid addiction, including the high cost and low value of acute care delivered by minimally trained providers and the fixation on short-term detoxification and rehab. The book offers specific guidance for practical integration of effective opioid use disorder treatment into a range of healthcare settings. Chapters also discuss the unique complexities of caring for special populations with OUD, such as pregnant people and those involved in the criminal legal system. The book concludes with personal experience from individuals with a history of OUD. Socially conscious and practical, Treating Opioid Use Disorder in General Medical Settings serves as a crucial evidence-based resource for physicians, nurse practitioners, physician assistants, nurses, and other healthcare professionals.

Opioid Therapy in the 21st Century

Author: Howard S. Smith

Publisher: Oxford University Press

ISBN:

Category: Medical

Page: 306

View: 509

Over the last thirty years, the concern of Pain Medicine practitioners about the potential for their patients to develop a dependence on opioids has left opioid therapy as a largely underutilized treatment. While there is no simple answer to chronic pain, opioids remain the only class of drugs capable of providing relief to patients experiencing serious pain. Opioid Therapy in the 21st Century, Second Edition fills a dearth of clinical knowledge about analgesics to aid practitioners in weighing the risks versus the benefits of opioid therapy for their chronic pain patients. This second edition provides updated information on recently approved opioids as well as approved indications for older opioids and clinical trials. Part of the Oxford American Pain Library, this concise guide serves as a practical, accessible reference for physicians across the range of primary care and medical specialties. It includes an overview of appropriate clinical applications of opioids, covering such topics as opioid pharmacology, route selection, and individualization of therapy, as well as strategies for managing and mitigating the risk of abuse, addiction, and diversion. There are also special sections dedicated to the unique needs of pediatric, geriatric, and palliative care patient populations.

Medications for Opioid Use Disorder Save Lives

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

ISBN:

Category: Medical

Page: 174

View: 501

The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.

Heroin and Other Opioids: Poppies' Perilous Children

Author: E.J. Sanna

Publisher: Simon and Schuster

ISBN:

Category: Juvenile Nonfiction

Page: 128

View: 321

Heroin, opium, morphine, and codeine—the natural opioids. In Heroin and Other Opioids: Poppies' Perilous Children, you'll learn about these substances as well as newer derivatives, all of which can impact lives in serious and negative ways. Take a trip through the history of opium production and use, and its role in political history. Discover that opioids were popular patent medicines, the primary ingredients of such "medicines" as Mrs. Winslow's Soothing Syrup, Hamlin's Wizard Oil, and other "cures for what ails you." Heroin and opioids didn't just go away when their use was outlawed. Instead, they became part of a large illegal narcotics market. Legal derivatives were also produced and marketed as effective treatments for pain and other conditions.

An Approach to Evaluate the Effects of Concomitant Prescribing of Opioids and Benzodiazepines on Veteran Deaths and Suicides

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

ISBN:

Category: Medical

Page: 110

View: 843

Opioid prescriptions for acute and chronic pain increased dramatically from the late 1990s into the current decade in both the civilian and the Department of Veterans Affairs and Department of Defense treatment environments. Similarly, prescriptions for benzodiazepines also increased significantly for anxiety and insomnia. Combinations of opioid and benzodiazepines have proven fatal when taken concurrently, with research demonstrating this phenomenon for nearly 40 years. This issue is exacerbated within the veteran population because of higher rates of pain, anxiety and other related health issues due to military life. An evaluation of the relationship between opioid and benzodiazepine medication practices at the VA is necessary to improve treatment for mental health and combat-related trauma for veterans. An Approach to Evaluate the Effects of Concomitant Prescribing of Opioids and Benzodiazepines on Veteran Deaths and Suicides investigates the effects of opioid initiation and tapering strategies in the presence of benzodiazepines in veterans. This report explores neurobiology and the principles of addiction and tolerance, in addition to the current use of opioids and benzodiazepines for treating pain and anxiety in both the veteran and general population. It also provides a protocol to evaluate the relationship between opioid and benzodiazepine medication practices. This framework is a critical foundation for further research to improve concomitant opioid and benzodiazepine medication practices for veterans and the general population.