Molecular Mechanisms of Tobacco-induced Diseases

Author: Xing Li Wang

Publisher: Nova Publishers

ISBN:

Category: Medical

Page: 450

View: 189

Despite a wealth of epidemiological evidence of the profound ill-effects of smoking on human health, we know surprisingly little about the pathogenic mechanisms by which tobacco smoke actually causes disease. Indeed, to our knowledge this publication represents the first book that is entirely devoted to the molecular and cellular mechanisms of tobacco-induced diseases. Considering that smoking will directly kill 650 million of those people currently alive, the lack of such a book represents a huge gap in the biomedical literature.This new and important book fills this gap.

Tobacco Smoking and Atherosclerosis

Pathogenesis and Cellular Mechanisms

Author: John N. Diana

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 404

View: 639

Atherosclerosis is the principal underlying cause of cardiovascular and cerebrovascular disease in people of the Western world. Cigarette smoking has been implicated in both the initiation and exacerbation of the atherosclerotic process. Data to support this implication derives primarily from epidemiologic studies where the relationship between the incidence of atherosclerosis in people who smoke cigarettes has been shown to have a strong correlation. There are few well established explanations for this phenomenon, and basic molecular, biochemical, and cellular mechanisms associated with smoking and the development of atherosclerosis remain both undefined and virtually unexplored. Even the epidemiologic correlation between cigarette smoking and the development of atherosclerosis needs further critical studies. It is known that individuals who do not smoke cigarettes develop athero sclerosis and it is also known that in people who smoke but have normal or low blood cholesterol/lipoprotein levels, the incidence of development of atherosclerosis is no different from that which is found in a non smoking population. Answers which explain such observations must address fundamental biological mechanisms. Toward this end, the purpose of this volume is to assemble, in a single publication, information which will address the questions; what basic cellular and/or molecular mechanisms are associated with the development of atherosclerosis and how does cigarette smoking influence such mechanisms to initiate or exacerbate the atherosclerotic process? Clearly, the development of atherosclerosis is a complex, multifactorial biological event.

Tobacco Smoking and Nutrition

Influence of Nutrition on Tobacco-associated Health Risks

Author: John N. Diana

Publisher:

ISBN:

Category: Science

Page: 392

View: 601

This work reviews epidemiological, chemical, biochemical, cellular and molecular mechanisms associated with both tobacco smoking-induced chronic health risks and the modification of such health risks by chemopreventive nutritional elements.

Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases

Overview of Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine

Author: Emilija Veljkovic

Publisher: Academic Press

ISBN:

Category: Science

Page: 164

View: 612

Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a comprehensive summary of the epidemiological data on smoking and several neurological disorders, including Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Tourette’s syndrome, schizophrenia, anxiety, depression and ADHD, as well as preclinical and clinical data on the effects of nicotine. Despite the obvious and undisputed harmful nature of smoking, evidence suggests that some tobacco and tobacco smoke-derived constituents may offer neuroprotective effects, possibly in combinations, rather than individually. This unprecedented book describes the complex relationships between smoking and neurological disease and the bioactive compounds found in tobacco. It provides a comprehensive review of nicotine and other compounds found in tobacco plant, with scientific evidence of neuroprotective and anti-inflammatory effects that may act in conjunction with nicotine to exert neuroprotective effects observed in smokers. By presenting findings beyond harmful cigarette smoke effects, attention can be drawn to individual compounds of tobacco that may serve as inspiration for further therapy development. Presents the first comprehensive, tabulated summary of literature on the epidemiological data on smoking and neurological disease Includes preclinical and clinical data on nicotine in neurological diseases and mechanisms of action of nicotine in neuroprotection Features a comprehensive summary of non-nicotine smoke constituents with potentially neuroprotective and anti-inflammatory properties Discusses Multiple Sclerosis, Alzheimer’s disease, Parkinson’s Disease, Schizophrenia, Depression, ADHD, Anxiety and Tourette’s Syndrome in the context of smoking and nicotine

Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment

Author: Ming D. Li

Publisher: Springer

ISBN:

Category: Medical

Page: 365

View: 310

This book provides the most recent knowledge on almost all key aspects of the health impact of tobacco smoking. Its 21 chapters focus on both preclinical and clinical studies. The contents are broad, covering the epidemiology of tobacco smoking; genetic epidemiology; identification of susceptibility genomic regions, genes, and pathways as determined by both human and animal studies; evolutionary relations among the different nAChR subunit genes that are so important to the nicotine response; smoking-related diseases; E-cigarettes; and smoking cessation. Furthermore, each chapter includes a detailed and comprehensive list of key references. For both clinical and basic researchers, this book is a valuable resource on nicotine dependence and other addictions.

Cigarette Smoke and Oxidative Stress

Author: Barry B. Halliwell

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 407

View: 996

The mechanism by which cigarette smoke causes or contributes to inflammatory diseases like chronic obstructive pulmonary disease, cardiovascular disease and cancer remains unclear. Recent developments in our knowledge of cellular signaling suggest that cigarette smoke may cause oxidative stress in cellular systems. The assessment, consequences and possible modulation of these effects are discussed in this book which will interest oncologists and researchers in Biochemistry.

International Encyclopedia of Public Health

Author: William C Cockerham

Publisher: Academic Press

ISBN:

Category: Medical

Page: 4470

View: 830

International Encyclopedia of Public Health, Second Edition is an authoritative and comprehensive guide to the major issues, challenges, methods, and approaches of global public health. Taking a multidisciplinary approach, this new edition combines complementary scientific fields of inquiry, linking biomedical research with the social and life sciences to address the three major themes of public health research, disease, health processes, and disciplines. This book helps readers solve real-world problems in global and local health through a multidisciplinary and comprehensive approach. Covering all dimensions of the field, from the details of specific diseases, to the organization of social insurance agencies, the articles included cover the fundamental research areas of health promotion, economics, and epidemiology, as well as specific diseases, such as cancer, cardiovascular diseases, diabetes, and reproductive health. Additional articles on the history of public health, global issues, research priorities, and health and human rights make this work an indispensable resource for students, health researchers, and practitioners alike. Provides the most comprehensive, high-level, internationally focused reference work available on public health Presents an invaluable resource for both researchers familiar with the field and non-experts requiring easy-to-find, relevant, global information and a greater understanding of the wider issues Contains interdisciplinary coverage across all aspects of public health Incorporates biomedical and health social science issues and perspectives Includes an international focus with contributions from global domain experts, providing a complete picture of public health issues

Free Radical Toxicology

Author: Kendall B Wallace

Publisher: CRC Press

ISBN:

Category: Medical

Page: 458

View: 1000

Provides insight into the involvement of free radicals in the pathogenesis of chemical-induced toxic tissue injury. The text addresses the fundamentals of free radical chemistry and the theoretical basis for electron transfer reaction leading to free radical generation. It describes the various subcellular sources of free radicals, the biological reactivity with lipid, protein and nucleic acids, and the physiochemical determinants of free radical-induced cell injury and the various antioxidant defence systems. The book focuses on target organ toxicity, and the concluding section offers an overview of the evidence implicating free radicals in the aetiology of various chemical toxicities, challenging the possibility of misguided use of biomarkers for oxidative damage.