Focusing on organic reactions, this text begins by introducing modern technology, definitions, and concepts of mechanisms and reactivity. The following four chapters are accounts of the mechanisms of four of the main classes of reactions of aliphatic compounds.
A range of alternative mechanisms can usually be postulated for most organic chemical reactions, and identification of the most likely requires detailed investigation. Investigation of Organic Reactions and their Mechanisms will serve as a guide for the trained chemist who needs to characterise an organic chemical reaction and investigate its mechanism, but who is not an expert in physical organic chemistry. Such an investigation will lead to an understanding of which bonds are broken, which are made, and the order in which these processes happen. This information and knowledge of the associated kinetic and thermodynamic parameters are central to the development of safe, efficient, and profitable industrial chemical processes, and to extending the synthetic utility of new chemical reactions in chemical and pharmaceutical manufacturing, and academic environments. Written as a coherent account of the principal methods currently used in mechanistic investigations, at a level accessible to academic researchers and graduate chemists in industry, the book is highly practical in approach. The contributing authors, an international group of expert practitioners of the techniques covered, illustrate their contributions by examples from their own research and from the relevant wider chemical literature. The book covers basic aspects such as product analysis, kinetics, catalysis, and investigation of reactive intermediates. It also includes material on significant recent developments, e.g. computational chemistry, calorimetry, and electrochemistry, in addition to topics of high current industrial relevance, e.g. reactions in multiphase systems, and synthetically useful reactions involving free radicals and catalysis by organometallic compounds.
Key texts in the renowned Oxford Chemistry Primers series have been fully refreshed and updated to suit the needs of today's students, lecturers, and postgraduate researchers. The rigorous and yet accessible treatment of each subject area is ideal for those wanting to know more about a particular topic not covered comprehensively in existing undergraduate texts. Moreover, cutting-edge examples and applications throughout the texts show the relevance of thechemistry being described to the real world. Pericyclic reactions constitute a fundamental class of organic chemistry, including such commercially important synthetic reactions as theDiels-Alder reaction. This primer gives a concise and accessible account of these reactions, enabling students to recognise the different types of pericyclic reaction and understand their application in organic synthesis.
The development of university organic chemistry curricula and thetrend towards modularisation of chemistry courses has driven theneed for smaller, highly focussed and accessible organic chemistrytextbooks, which complement the very detailed “standardtexts”, to guide students through the key principles of thesubject. This concise and accessible book provides organic chemistrynotes for students studying chemistry and related courses atundergraduate level, covering core organic chemistry in a formatideal for learning and rapid revision. The material is organised sothat fundamental concepts are introduced early, then built on toprovide an overview of the essentials of functional group chemistryand reactivity, leading the student to a solid understanding of thebasics of organic chemistry. Graphical presentation of informationis central to the book, to facilitate the rapid assimilation,understanding and recall of critical concepts, facts anddefinitions. Students wanting a comprehensive and accessible overview oforganic chemistry to build the necessary foundations for a moredetailed study will find this book an ideal source of theinformation they require. In addition, the structured presentation,highly graphical nature of the text and practice problems withoutline answers will provide an invaluable framework and aid torevision for students preparing for examinations.
This English edition of a best-selling and award-winning German textbook Reaction Mechanisms: Organic Reactions · Stereochemistry · Modern Synthetic Methods is aimed at those who desire to learn organic chemistry through an approach that is facile to understand and easily committed to memory. Michael Harmata, Norman Rabjohn Distinguished Professor of Organic Chemistry (University of Missouri) surveyed the accuracy of the translation, made certain contributions, and above all adapted its rationalizations to those prevalent in the organic chemistry community in the English-speaking world. Throughout the book fundamental and advanced reaction mechanisms are presented with meticulous precision. The systematic use of red "electron-pushing arrows" allows students to follow each transformation elementary step by elementary step. Mechanisms are not only presented in the traditional contexts of rate laws and substituent effects but, whenever possible, are illustrated using practical, useful and state-of-the-art reactions. The abundance of stereoselective reactions included in the treatise makes the reader familiar with key concepts of stereochemistry. The fundamental topics of the book address the needs of upper-level undergraduate students, while its advanced sections are intended for graduate-level audiences. Accordingly, this book is an essential learning tool for students and a unique addition to the reference desk of practicing organic chemists, who as life-long learners desire to keep abreast of both fundamental and applied aspects of our science. In addition, it will well serve ambitious students in chemistry-related fields such as biochemistry, medicinal chemistry and pharmaceutical chemistry. From the reviews: "Professor Bruckner has further refined his already masterful synthetic organic chemistry classic; the additions are seamless and the text retains the magnificent clarity, rigour and precision which were the hallmark of previous editions. The strength of the book stems from Professor Bruckner’s ability to provide lucid explanations based on a deep understanding of physical organic chemistry and to limit discussion to very carefully selected reaction classes illuminated by exquisitely pertinent examples, often from the recent literature. The panoply of organic synthesis is analysed and dissected according to fundamental structural, orbital, kinetic and thermodynamic principles with an effortless coherence that yields great insight and never over-simplifies. The perfect source text for advanced Undergraduate and Masters/PhD students who want to understand, in depth, the art of synthesis ." Alan C. Spivey, Imperial College London "Bruckner’s ‘Organic Mechanisms’ accurately reflects the way practicing organic chemists think and speak about organic reactions. The figures are beautifully drawn and show the way organic chemists graphically depict reactions. It uses a combination of basic valence bond pictures with more sophisticated molecular orbital treatments. It handles mechanisms both from the "electron pushing perspective" and from a kinetic and energetic view. The book will be very useful to new US graduate students and will help bring them to the level of sophistication needed to be serious researchers in organic chemistry." Charles P. Casey, University of Wisconsin-Madison "This is an excellent advanced organic chemistry textbook that provides a key resource for students and teachers alike." Mark Rizzacasa, University of Melbourne, Australia.
The carbonyl group is the commonest functional unit of organic chemistry and a thorough understanding of its reactivity is fundamental for organic synthesis. It appears in many classes of compound, of which aldehydes, ketones, and carboxylic acid derivatives are the most important. This Primer covers the chemistry of these classes within an up-to-date mechanistic framework which embraces reactions with simple nucleophiles (hydration, acetal formation, and condensation with aminonucleophiles); enols and enolates; and their reactions with electrophiles, including alkylating agents and carbonyl groups. Core Carbonyl Chemistry is central to organic chemistry and will be invaluable to students taking chemistry or biochemistry courses at University.
This book covers areas of mechanistic and physical organic chemistry at advanced undergraduate level in a non-mathematical way. The topics included (e.g. kinetics and mechanism, catalysis, and isotope effects) are essential in any modern chemistry degree, yet are not included in standard organic chemistry text books for undergraduates. The book is thoroughly up to date and includes many examples from all areas of organic chemistry.
Most reactions in organic chemistry do not proceed in a single step but rather take several steps to yield the desired product. In the course of these multi-step reaction sequences, short-lived intermediates can be generated that quickly convert into other intermediates, reactants, products or side products. As these intermediates are highly reactive, they cannot usually be isolated, but their existence and structure can be proved by theoretical and experimental methods. Using the information obtained, researchers can better understand the underlying reaction mechanism of a certain organic transformation and thus develop novel strategies for efficient organic synthesis. The chapters are clearly structured and are arranged according to the type of intermediate, providing information on the formation, characterization, stereochemistry, stability, and reactivity of the intermediates. Additionally, representative examples and a problem section with different levels of difficulty are included for self-testing the newly acquired knowledge. By providing a deeper understanding of the underlying concepts, this is a musthave reference for PhD and Master Students in organic chemistry, as well as a valuable source of information for chemists in academia and industry working in the field. It is also ideal as primary or supplementary reading for courses on organic chemistry, physical organic chemistry or analytical chemistry.