High-throughput ‘omics’ projects such as genome sequencing, structural genomics and proteomics mean that there is no shortage of information on proteins. But the more information we have, the harder it is to make sense of it, to know where to start, and to identify the important results. This book is a clear, up to date and authoritative account of the principles that govern the way proteins work, and sets proteins within the context in which they function: within the cell, within biological systems, and within the limitations fixed by physics, chemistry, and evolution, taking examples from many different areas of biology. It provides an integrated view of proteins, showing how evolutionary pressure has driven proteins to adopt a domain structure, and to put these domains together in various combinations in order to achieve a biological outcome. It shows how the association of proteins into dimers, complexes (molecular machines) and multi-enzyme complexes allows them to achieve remarkable catalytic and functional efficiency. It shows how evolution has led to an accumulation of regulatory and scaffold proteins, particularly with reference to signaling pathways; and it presents current views of protein dynamics and interactions. For the student it provides a framework, showing where old and new results fit in, and for the postgraduate and researcher it provides an up to date and coherent account of the relationship between protein function, structure and dynamics.
Essential Cell Biology provides a readily accessible introduction to the central concepts of cell biology, and its lively, clear writing and exceptional illustrations make it the ideal textbook for a first course in both cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive conceptual framework for the basic science that underlies our current understanding of all of biology, including the biomedical sciences. The Fourth Edition has been thoroughly revised, and covers the latest developments in this fast-moving field, yet retains the academic level and length of the previous edition. The book is accompanied by a rich package of online student and instructor resources, including over 130 narrated movies, an expanded and updated Question Bank. Essential Cell Biology, Fourth Edition is additionally supported by the Garland Science Learning System. This homework platform is designed to evaluate and improve student performance and allows instructors to select assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard. Students receive immediate feedback on their mastery of the topics, and will be better prepared for lectures and classroom discussions. The user-friendly system provides a convenient way to engage students while assessing progress. Performance data can be used to tailor classroom discussion, activities, and lectures to address students’ needs precisely and efficiently. For more information and sample material, visit http://garlandscience.rocketmix.com/.
A coherent introduction to the complete range of soliton theory including Hirota's method and Backlund transformations. Details physical applications of soliton theory with chapters on the peculiar wave patterns of the Andaman Sea, atmospheric phenomena, general relativity and Davydov solitons. Contains testing for full integrability, a discussion of the Painlevé technique, symmetries and conservation law.
A NATO Advanced Research Workshop entitled New Methods for the Study of Molecular Aggregates was held at Tbe Lodge at Kananaskis Village, Alberta, Canada from 16 -20 June 1996. In fact the meeting was entirely concerned with the problem of analyzing biomolecular complexes, so the title of these proceedings has been altered to give a more precise description of the content. Tbe workshop was hosted by the time-of-flight group of the Department of Physics at the University of Manitoba, and was attended by 64 participants from around the world. '!\venty-one invited talks were given and 27 papers were presented as posters. Of the 48 contributions, 22 papers (12 orals, 10 posters) are included in these proceedings. Tbe subject of the conference was the investigation of noncovalent biomolecular complexes, with particular focus on the application of mass spectrometry to their characterization. '!\vo new ionization techniques introduced in the late 1980s, electrospray ionization (ES I) and matrix-assisted laser desorptionlionization (MALDI), resulted in a breakthrough in mass spectrometry, enabling its use in molecular weight and primary structure determination of biopolymers larger than 100 kDa. Recently it has been discovered that ESI mass spectrometry mayaiso be used to characterize complexes containing noncovalent interactions, thus opening new perspectives for supramolecular chemistry. ESI mass spectrometry has the advantage that the sampie is introduced from a homogenous solution which can be maintained at near physiological conditions of pR, concentration, and temperature.
Proceedings of the Third Conference : June 17-21 2002, San Lorenzo de El Escorial Madrid
Author: Robert Sinclair MacKay
Publisher: World Scientific
This conference was the third meeting organized in the framework of the European LOCNET project. The main topics discussed by this international research collaboration were localization by nonlinearity and spatial discreteness, and energy transfer (in crystals, biomolecules and Josephson arrays).
A Positron Named Priscilla is a book of wonder, offering a fascinating, readable overview of cutting-edge investigations by many of today's leading young scientists. Written for anyone who loves science, this volume reports on some of the most exciting recent discoveries and advances in fields from astronomy to molecular biology. This new book is from one of the world's most prestigious scientific institutions, the National Academy of Sciences. The Academy provides an annual forum for the brightest young investigators to exchange ideas across disciplines--an exchange that was the spark for A Positron Named Priscilla. Each chapter is authored by a popular science writer who offers helpful historical perspectives, clear and well-illustrated explanations of current scientific thinking, and previews of future developments. The scope of topics and breadth of discussion ensure interest at all levels. Topics include Planetary science and the compelling glimpse through the clouded atmosphere of Venus afforded by the spacecraft Magellan. Astrophysics and the emergence of helioseismology, a new field that allows researchers to probe the interior workings of the sun. Biology and what we have learned about DNA in the 40 years since its discovery; our current understanding of protein molecules, the "building blocks" of living systems; and the high-tech search for answers to the AIDS epidemic. Physics and our new-found ability to move and manipulate individual atoms on a surface. The book also tells the remarkable story of "buckyballs," or buckminsterfullerenes, a form of carbon discovered only a few years ago, that have the potential to be used in a variety of important applications, from superconductivity to nanotechnology. Mathematics and the rise of "wavelet" theory, and how mathematicians are applying it in sometimes startling ways, from assisting the FBI with fingerprint storage to coaxing the secrets from a battered recording of Brahms playing the piano. Geosciences and the search for "clocks in the earth" to make life-saving earthquake predictions. A Positron Named Priscilla is a "must" read for anyone who wants to keep up with a broad range of scientific endeavor.
We are in the midst of a revolution. It is a scientific revolution built upon the tools of molecular biology, with which we probe and prod the living world in ways unimaginable a few decades ago. Need to track a bacterium at the root of a hospital outbreak? No problem: the offending germ's complete genetic profile can be obtained in 24 hours. We insert human DNA into E. coli bacteria to produce our insulin. It is natural to look at biotechnology in the 21st century with a mix of wonder and fear. But biotechnology is not as 'unnatural' as one might think. All living organisms use the same molecular processes to replicate their genetic material and the same basic code to 'read' their genes. The similarities can be seen in their DNA. Here, John Archibald shows how evolution has been 'plugging-and-playing' with the subcellular components of life from the very beginning and continues to do so today. For evidence, we need look no further than the inner workings of our own cells. Molecular biology has allowed us to gaze back more than three billion years, revealing the microbial mergers and acquisitions that underpin the development of complex life. One Plus One Equals One tells the story of how we have come to this realization and its implications.
By combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
Each chapter of this volume is a contribution from an expert in the field, chosen by the editors to contribute to the 1997 "Current Issues in Blood Substitute Research and Development" course given in San Diego, March 17-19. The contributors were selected because of their expertise in areas which the editors believe to be critical to the advancement of the field, and which reflect activity in "hot" areas of relevant research. While there is a continuity in style for the annual course, each year brings changes in emphasis and content. In previous years, we were often not able to provide time for participants to present their views and opinions. Consequently, this year we encouraged discussion after each presentation. These sessions were recorded, transcribed, and are printed with the chapters herein. We believe that the product is very close to the capturing this year's course in print, and trust readers will enjoy reading the always candid and often provocative remarks from the audience. The price paid for inclusion of the discussion transcriptions was a delay in publication. Each author was allowed to edit his/her discussion section as well as the final version of the chapters prior to publication. The changes are mainly for grammar, and we tried, when possible, not to alter the conversational style of these interchanges.