The second edition of this volume provides up-to-date methods on the main methodological aspects of functional MRI (fMRI), applying fMRI to the study of central nervous system, and future evolutions of fMRI techniques. fMRI: Method and Protocols, Second Edition guides the reader through chapters on basic knowledge for the understanding of the technical aspects of fMRI, overview of the main results derived from the application of fMRI to the study of healthy individuals, application of fMRI to assess the role of brain plasticity in the major neurological and psychiatric conditions, and novel approaches for the integration of fMRI data. Concise and easy-to-use, fMRI: Method and Protocols, Second Edition aims to be useful to clinicians and researchers with a user-friendly summary of the field and necessary background ensuring further successful studies.
Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. • Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods • Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more • Clear, straightforward explanations of each technique for anyone new to the field • A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture • Detailed recommendations on where to find protocols and other resources for specific techniques • “Walk-through boxes that guide readers through experiments step-by-step
Basic Principles and Emerging Clinical Applications for Anesthesiology and the Neurological Sciences
Author: Ramachandran Ramani
Publisher: Oxford University Press
Functional MRI: Basic Principles and Emerging Clinical Applications provides an overview of the basic principles of fMRI for clinicians with minimal knowledge of the imaging technique and its research potential and clinical applications. The text is divided into two parts, with Section I covering the primary signal measured in fMRI (BOLD), the correlation between neuronal activity and the BOLD signal, and how the data is analyzed and interpreted in fMRI. Section II explores applications of fMRI in cognitive neuroscience and common psychiatric disorders, surgical planning in neurosurgery, anesthesia and the intensive care unit, and more. Timely and highly accessible, this book is a valuable resource for researchers and clinicians interested in understanding what fMRI is, how it works, and its applications.
During the last two decades, new developments in functional MRI (magnetic resonance imaging) have made it possible to detect changes in the brain over time, as opposed to the "snapshot" produced by conventional MRI. Essentials of Functional MRI breaks down the technical challenges for physicians, researchers, and technologists who use functional MRI but may not be experts in the necessary math and physics. The author describes the theory and practical details of functional MRI (fMRI) methodology, including how to acquire and analyze images, and a wide range of examples demonstrate how fMRI has been used thus far. The author provides the essential information to study, understand, use, and teach the practical aspects of fMRI for those people who are most likely to extend its use into clinical practice.
The Routledge Encyclopedia of Second Language Acquisition offers a user-friendly, authoritative survey of terms and constructs that are important to understanding research in second language acquisition (SLA) and its applications. The Encyclopedia is designed for use as a reference tool by students, researchers, teachers and professionals with an interest in SLA. The Encyclopedia has the following features: • 252 alphabetized entries written in an accessible style, including cross references to other related entries in the Encyclopedia and suggestions for further reading • Among these, 9 survey entries that cover the foundational areas of SLA in detail: Development in SLA, Discourse and Pragmatics in SLA, Individual Differences in SLA, Instructed SLA, Language and the Lexicon in SLA, Measuring and Researching SLA, Psycholingustics of SLA, Social and Sociocultural Approaches to SLA, Theoretical Constructs in SLA. • The rest of the entries cover all the major subdisciplines, methodologies and concepts of SLA, from “Accommodation” to the “ZISA project.” Written by an international team of specialists, the Routledge Encyclopedia of Second Language Acquisition is an invaluable resource for students and researchers with an academic interest in SLA.
Remarkable advances in imaging have increased the importance of MRI for diagnostic, treatment and management of epilepsy. Neuroimaging of patients with epilepsy no longer simply deals with the technology and interpretation of images but also with issues of brain metabolism, energetics, cognition and brain dysfunction. The first edition of Magnetic Resonance in Epilepsy came into clinical practice in 1995 with a revolutionary idea; that is, MR is as important as EEG in the clinical management of patients with epilepsy. The second edition of Magnetic Resonance in Epilepsy, the only comprehensive text in the field of epilepsy neuroimaging, reviews fundamental concepts and new advances in MR technology, computerized analysis, MR spectroscopy, DWI and other neuroimaging techniques such as PET, SPECT and MEG application to the study of patients with epileptic disorders. *Provides a crucial update of recent advances in imaging techniques *Timely publication as subject of neuroimaging is a very "hot" area in both clinical epilepsy and basic neuroscience research *Editors are well-respected in this field
This book will provide the reader with a solid overview of the mechanisms and models in the neuroscience of attentional control and selection from leading authorities working in humans and animals, and incorporating a array of neuroscience methods from single neuron recordings to functional brain imaging.
With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access. The text has been thoroughly updated, with new information on biopharmaceuticals and vaccines as well as clinical development and target identification. Drug discovery and development continues to evolve rapidly and this new edition reflects important changes in the landscape. Edited by industry experts Raymond Hill and Duncan Richards, this market-leading text is suitable for undergraduates and graduates undertaking degrees in pharmacy, pharmacology, toxicology, and clinical development through to those embarking on a career in the pharmaceutical industry. Key stages of drug discovery and development Chapters outline the contribution of individual disciplines to the overall process Supplemented by specific chapters on different modalities Includes coverage of Oligonucleotide therapies; cell and gene therapy Now comes with online access on StudentConsult