**Author**: Domitilla Del Vecchio

**Publisher:** Princeton University Press

**ISBN:**

**Category:** Science

**Page:** 288

**View:** 593

This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources. Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems. Provides a user-friendly introduction to essential concepts, tools, and applications Covers the most commonly used modeling methods Addresses the modular design problem for biomolecular systems Uses design examples from both natural systems and synthetic circuits Solutions manual (available only to professors at press.princeton.edu) An online illustration package is available to professors at press.princeton.edu

Feedback Systems: Input-output Properties deals with the basic input-output properties of feedback systems. Emphasis is placed on multiinput-multioutput feedback systems made of distributed subsystems, particularly continuous-time systems. Topics range from memoryless nonlinearities to linear systems, the small gain theorem, and passivity. Norms and general theorems are also considered. This book is comprised of six chapters and begins with an overview of a few simple facts about feedback systems and simple examples of nonlinear systems that illustrate the important distinction between the questions of existence, uniqueness, continuous dependence, and boundedness with respect to bounded input and output. The next chapter describes a number of useful properties of norms and induced norms and of normed spaces. Several theorems are then presented, along with the main results concerning linear systems. These results are used to illustrate the applications of the small gain theorem to different classes of systems. The final chapter outlines the framework necessary to discuss passivity and demonstrate the applications of the passivity theorem. This monograph will be a useful resource for mathematically inclined engineers interested in feedback systems, as well as undergraduate engineering students.

This book provides an introduction to the mathematics needed to model, analyze, and design feedback systems. It is an ideal textbook for undergraduate and graduate students, and is indispensable for researchers seeking a self-contained reference on control theory. Unlike most books on the subject, Feedback Systems develops transfer functions through the exponential response of a system, and is accessible across a range of disciplines that utilize feedback in physical, biological, information, and economic systems. Karl Åström and Richard Murray use techniques from physics, computer science, and operations research to introduce control-oriented modeling. They begin with state space tools for analysis and design, including stability of solutions, Lyapunov functions, reachability, state feedback observability, and estimators. The matrix exponential plays a central role in the analysis of linear control systems, allowing a concise development of many of the key concepts for this class of models. Åström and Murray then develop and explain tools in the frequency domain, including transfer functions, Nyquist analysis, PID control, frequency domain design, and robustness. They provide exercises at the end of every chapter, and an accompanying electronic solutions manual is available. Feedback Systems is a complete one-volume resource for students and researchers in mathematics, engineering, and the sciences. Covers the mathematics needed to model, analyze, and design feedback systems Serves as an introductory textbook for students and a self-contained resource for researchers Includes exercises at the end of every chapter Features an electronic solutions manual Offers techniques applicable across a range of disciplines

Synthesis of Feedback Systems presents the feedback theory which exists in various feedback problems. This book provides techniques for the analysis and solution of these problems. The text begins with an introduction to feedback theory and exposition of problems of plant identification, representation, and analysis. Subsequent chapters are devoted to the application of the feedback point of view to any system; the principal useful properties of feedback; the feedback control system synthesis techniques; and the class of two degree-of-freedom feedback configurations and synthesis procedures appropriate for such configurations. The final chapter considers how to translate specifications from their typical original formulation, to the language appropriate for detailed design. The book is intended for engineers and graduate students of engineering design.

This monograph is an attempt to develop further and refine methods based on input -output descriptions for analyzing feedback systems. Contrary to previous work in this area, the treatment heavily emphasizes and exploits the causality of the operators involved. This brings the work into closer contact with the theory of dynamical systems and automata.

This book presents the outcome of the European Summer School on Multi-agent Control, held in Maynooth, Ireland in September 2003. The past decade witnessed remarkable progress in the area of dynamic systems with the emergence of a number of powerful methods for both modeling and controlling uncertain dynamic systems. The first two parts of this book present tutorial lectures by leading researchers in the area introducing the reader to recent achievements on switching and control and on Gaussian processes. The third part is devoted to the presentation of original research contributions in the area; among the topics addressed are car control, bounding algorithms, networked control systems, the theory of linear systems, Bayesian modeling, and surveying multiagent systems.

Phase-Locked and Frequency-Feedback Systems: Principles and Techniques presents the operating principles and methods of design of phase-locked and frequency-feedback systems. This book is divided into 10 chapters that provide step-by-step design procedures and graphical aids, with illustrations bearing on real problems experienced in these systems. This work specifically tackles the application of these systems as FM demodulators with lowered thresholds. Chapters 1 and 2 deal briefly with the elements of linear systems, feedback theory, and noise, providing the minimum background for the material presented in the remainder of the text. Chapter 3 describes the characteristics of the major components that comprise the loops and the performance of the conventional and multi-loop FM demodulators. Chapters 4 to 7 present the basic describing equations and design for the FM feedback (FMFB) and phase-locked loop (PLL). These chapters further illustrate step-by-step design procedures with performance characteristics for low-threshold angle demodulation using typical design examples. Chapter 8 highlights the design principles, which are extended to the design of advanced demodulators featuring demodulation thresholds lower than those of the simple PLL or FMFB. Chapter 9 focuses on digital FM demodulation and PLL applications other than FM demodulation. Lastly, Chapter 10 presents the methods of testing and evaluating loop performance. Undergraduate and graduate level students, as well as practicing engineers, will find this book invaluable.

Integral Equations and Stability of Feedback Systems

Study of dynamical systems usually concentrates on the properties and the structure of invariant sets, since the understanding of these is the first step in describing the long time behavior of orbits of the entire dynamical system. There are two different sets of problems related to the study of dynamical systems. One, the study of the dynamics in the neighborhood of the critical elements like fixed points or periodic orbits, is relatively well understood. This volume tackles the second set of problems, related to a global dynamics and the global bifurcations. In this volume the author studies dynamics of cyclic feedback systems. The global dynamics is described by a Morse decomposition of the global attractor, defined with the help of a discrete Lyapunov function.The author shows that the dynamics inside individual Morse sets may be very complicated. A three-dimensional system of ODEs with two linear equations is constructed, such that the invariant set is at least as complicated as a suspension of a full shift on two symbols. The questions posed are perhaps as significant as the reported results.

This volume collects together state-of-the-art contributions to the IEEE workshop on Nonlinear Dynamics of Electronic Systems.

Quantitative Feedback Design of Linear and Nonlinear Control Systems is a self-contained book dealing with the theory and practice of Quantitative Feedback Theory (QFT). The author presents feedback synthesis techniques for single-input single-output, multi-input multi-output linear time-invariant and nonlinear plants based on the QFT method. Included are design details and graphs which do not appear in the literature, which will enable engineers and researchers to understand QFT in greater depth. Engineers will be able to apply QFT and the design techniques to many applications, such as flight and chemical plant control, robotics, space, vehicle and military industries, and numerous other uses. All of the examples were implemented using Matlab® Version 5.3; the script file can be found at the author's Web site. QFT results in efficient designs because it synthesizes a controller for the exact amount of plant uncertainty, disturbances and required specifications. Quantitative Feedback Design of Linear and Nonlinear Control Systems is a pioneering work that illuminates QFT, making the theory - and practice - come alive.

Like engineering systems, biological systems must also operate effectively in the presence of internal and external uncertainty—such as genetic mutations or temperature changes, for example. It is not surprising, then, that evolution has resulted in the widespread use of feedback, and research in systems biology over the past decade has shown that feedback control systems are widely found in biology. As an increasing number of researchers in the life sciences become interested in control-theoretic ideas such as feedback, stability, noise and disturbance attenuation, and robustness, there is a need for a text that explains feedback control as it applies to biological systems. Written by established researchers in both control engineering and systems biology, Feedback Control in Systems Biology explains how feedback control concepts can be applied to systems biology. Filling the need for a text on control theory for systems biologists, it provides an overview of relevant ideas and methods from control engineering and illustrates their application to the analysis of biological systems with case studies in cellular and molecular biology. Control Theory for Systems Biologists The book focuses on the fundamental concepts used to analyze the effects of feedback in biological control systems, rather than the control system design methods that form the core of most control textbooks. In addition, the authors do not assume that readers are familiar with control theory. They focus on "control applications" such as metabolic and gene-regulatory networks rather than aircraft, robots, or engines, and on mathematical models derived from classical reaction kinetics rather than classical mechanics. Another significant feature of the book is that it discusses nonlinear systems, an understanding of which is crucial for systems biologists because of the highly nonlinear nature of biological systems. The authors cover tools and techniques for the analysis of linear and nonlinear systems; negative and positive feedback; robustness analysis methods; techniques for the reverse-engineering of biological interaction networks; and the analysis of stochastic biological control systems. They also identify new research directions for control theory inspired by the dynamic characteristics of biological systems. A valuable reference for researchers, this text offers a sound starting point for scientists entering this fascinating and rapidly developing field.