Diagnostic Pathology: Molecular Oncology E-Book

Author: Mohammad A Vasef

Publisher: Elsevier Health Sciences

ISBN:

Category: Medical

Page: 1000

View: 230

Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology series is an expert resource for pathologists at all levels of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills. This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical, clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies. Provides updated information on molecular mutations in different tumors, including solid tumors and hematopoietic neoplasms, and new targeted therapies geared toward these molecular alterations Discusses now widely used immunotherapy treatments, including how immunotherapy has revolutionized the treatment of many neoplasms such as breast and lung carcinomas and lymphoma Features more than 2,000 annotated images throughout, including H&E stains, immunostains, and FISH images Covers timely topics such as: Recent advances in cancer immunotherapy, specifically in the molecular basis of immunotherapy Newly discovered targeted therapies, including multiple lung carcinoma therapies now considered for patients based on existing mutations to specific genes (KRAS, ALK, BRAF, and ROS) The need for integration of myeloid and lymphoid gene panels due to increased knowledge from next generation sequencing studies of new mutations and the resulting newly developed molecular targets Increased usage of next generation sequencing techniques Changes to hematopoietic tumor details based on revised WHO guidelines Recipient of a 2016 BMA Award: Highly Commended, Pathology (previous edition)

Diagnostic Pathology - Molecular Oncology

Author: Mohammad A. Vasef

Publisher: Elsevier

ISBN:

Category:

Page: 1016

View: 478

Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology?series is an expert resource for pathologists at all levels of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills. This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical, clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies. Provides updated information on molecular mutations in different tumors, including solid tumors and hematopoietic neoplasms, and new targeted therapies geared toward these molecular alterations Discusses now widely used immunotherapy treatments, including how immunotherapy has revolutionized the treatment of many neoplasms such as breast and lung carcinomas and lymphoma Features more than 2,000 annotated images throughout, including H&E stains, immunostains, and FISH images Covers timely topics such as: Recent advances in cancer immunotherapy, specifically in the molecular basis of immunotherapy Newly discovered targeted therapies, including multiple lung carcinoma therapies now considered for patients based on existing mutations to specific genes (KRAS, ALK, BRAF, and ROS) The need for integration of myeloid and lymphoid gene panels due to increased knowledge from next generation sequencing studies of new mutations and the resulting newly developed molecular targets Increased usage of next generation sequencing techniques Changes to hematopoietic tumor details based on revised WHO guidelines Recipient of a 2016 BMA Award: Highly Commended, Pathology (previous edition) Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Diagnostic Pathology: Molecular Oncology

Author: Mohammed A. Vasef

Publisher: Amirsys

ISBN:

Category: Cancer

Page: 936

View: 838

"Molecular Oncologic Pathology is one of the most dynamic fields of medicine and has become an intregral part of the field of pathology in particular. Introduction of massively parallel sequencing technology (aka next generation sequencing) in recent years resulted in discovery of several clinically actionable somatic mutations in solid tumors and in hematologic malignancies. These discoveries have refined our understanding of molecular pathogenesis of human diseases in general and have led to the discovery of many new molecular targeted therapies particularly in human cancers. Several of the recently discovered molecular genetic findings have already become critical for the diagnosis of distinct disease entities and key to personalized medicine. In oncologic pathology, these advancements have dramatically changed the role of the pure morphologic and immunophenotypic-based pathologist to that of a consultant who incorporates molecular genetic results into the pathology report and comprehensively interprets molecular data by creating an integrated report with the most clinically useful data in diagnostic line. Understanding new molecular information can be difficult for pathologists, clinicians, residents and medical students. This book is intended to serve as a guide for practicing pathologists, pathology residents and fellows to keep up with the rapidly evolving practice of pathology in era of personalized medicine. Diagnostic Pathology: Molecular Oncology is detailed, richly illustrated reference covering molecular tests and their clinical applications along with organ based chapters on the molecular genetic data relevant to individual disease entities. Focusing on accurate interpretation and diagnosis as well as molecular testing allows the creation of integrated reports that would guide oncologists in making proper treatment decisions. There is a scarcity of molecular pathology textbooks that are comprehensive, but easy to understand. Traditional textbooks are commonly paragraph-based with few photographs. In contrast, this book is extensively illustrated and written in a concise bulleted format, to allow the reader to easily find relevant information. The information covered in the text is cutting edge. Knowledge of the rapidly growing body of information regarding molecular pathology is essential to the understanding of modern day medicine. We hope that this textbook will be a valuable guide for this purpose. No book in the molecular genetic pathology can be considered complete given the dynamic nature of the field. Therefore, we invite the readers to share their thoughts and appreciate any feedback."--Provided by publisher.

Diagnostic Pathology: Spleen - E-Book

Author: Aaron Auerbach

Publisher: Elsevier Health Sciences

ISBN:

Category: Medical

Page: 556

View: 819

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis Includes 14 new chapters covering topics such as autoimmune disease involving the spleen, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, leukemic non-nodal mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many others Includes approximately 2,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis Includes updated criteria, terminology, and classifications from the 2017 World Health Organization Classification of Lymphoid Neoplasms Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care

Diagnostic Molecular Pathology

A Guide to Applied Molecular Testing

Author: William B. Coleman

Publisher: Academic Press

ISBN:

Category: Science

Page: 582

View: 936

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions. Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease Features an ancillary website with self-testing exercises where decision trees can be employed to simulate actual clinical decisions Highlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests

Molecular Pathology and Diagnostics of Cancer

Author: Domenico Coppola

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 601

View: 981

Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.

Molecular Oncology Testing for Solid Tumors

A Pragmatic Approach

Author: Michael Ola Idowu

Publisher: Springer

ISBN:

Category: Medical

Page: 742

View: 161

Familiarity with and understanding molecular testing is becoming imperative for practicing physicians, especially pathologists and oncologists given the current explosion of molecular tests for diagnostic, prognostic and predictive indications. Molecular Oncology Testing for Solid Tumors is designed to present an up to date practical approach to molecular testing in a easy to understand format. Emphasis is placed on quality assurance (pre-analytic, analytic and post-analytic) and test interpretation, including but not limited to: the important role of pathologists in ensuring specimen adequacy for molecular testing; factors to consider in choosing platforms for molecular assays; advantages and limitations inherent to common assays/platforms that pathologists need to communicate effectively with clinicians; the importance of required quality assurance measures to ensure accurate / reproducible results; pitfalls in test interpretation (including different types of artifacts that may lead to False Positive or False Negative interpretations); test reporting using standard nomenclature; review of the current and future potential utility of next-generation sequencing in oncology. All chapters are written by pathologists and clinicians experienced in practical applications of molecular tests for solid tumors. The uniqueness of this textbook is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. This will enable readers to easily understand the Order, Report and Evaluate (ORE) process of molecular tests. Lastly, summary tables of all the molecular assays and mutations discussed in the text are provided as an appendix for quick reference. For readers interested in more detailed information, a link to websites where additional information can be obtained is provided.

Diagnostic Pathology: Blood and Bone Marrow

Author: Kathryn Foucar

Publisher: Amirsys

ISBN:

Category: Medical

Page: 976

View: 748

"Part of the highly regarded Diagnostic Pathology series, Diagnostic Pathology: Blood and Bone Marrow, second edition includes today's most recent knowledge on the latest finds in this subspecialty. New chapters focus on current molecular insights into the pathogenesis of familial disorders and neoplasms, ensuring pathologists, hematopathologists, hematologists, and oncologists alike can deliver the most up-to-date diagnoses possible. Concise, bulleted text coupled with extensive illustrations makes this succinct yet comprehensive reference ideal for clinical use."--Provided by publisher.

Diagnostic Pathology: Spleen

Author: Aaron Auerbach

Publisher: Elsevier

ISBN:

Category: Medical

Page: 556

View: 862

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses. Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms. Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis. Includes 14 new chapters covering topics such autoimmune disease involving the spleen, COVID-19-related diseases, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, primary splenic mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many more. Includes approximately 2,000 high-quality clinical and histological images, gross pathology images, radiologic images, and full-color drawings to help practicing and in-training pathologists reach a confident diagnosis. Includes updated criteria, terminology, and classifications from the 2017 WHO Classification of Lymphoid Neoplasms. Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care. Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices.

Diagnostic Pathology of Pleuropulmonary Neoplasia

Author: Annikka Weissferdt

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 470

View: 839

Diagnostic Pathology of Pleuropulmonary Neoplasia highlights the morphologic basis, immunohistochemistry, electron microscopy, and molecular biology of tumoral and pseudotumoral conditions of the lung and pleura. The volume also highlights the nuances in the diagnosis of lung and pleural conditions and the applications of today’s most recent studies in molecular biology, and the way it is applied to diagnosis and treatment. In providing an expert guide for the histopathologic diagnosis of lung and pleural tumors, this volume be of great interest to general surgical pathologists, surgeons, oncologists, and those involved in the management of patients with lung tumors.