The result of 3 decades of original research and instruction by internationally referenced authors, Drs. Joseph Altman and Shirley A. Bayer, the Atlas of Prenatal Rat Brain Development provides a complete, state-of-the-art presentation of the developing prenatal rat brain. With the aid of advanced computer graphics, Altman and Bayer revolutionize the study of the highly vulnerable prenatal brain and bring us closer to understanding the dynamics of its development, its malfunctions, deficits, and abnormalities. Their contributions to the field of brain research, and hence to our knowledge of brain disorders, are unsurpassed. The Atlas contains more than 265 platesÛeach plate accompanied by a computer-aided drawing, a 3-dimensional reconstruction of brain slices never before achieved with such accuracy and clarity, that assists in the visualization of the brain and of the relationships among various brain regions. A new, user-friendly alphanumeric coding system is used, allowing for easy identification of brain regions.
There are other rat brain atlases available, but this is the definitive atlas of the early and late gestational age rat brain. It shows the development of anatomical structures from embryonic day 13 to the day of birth, using section-by-section photomicrographs together with accompanying line diagrams. Over 750 structures are identified, giving functional as well as anatomical descriptions, including up to eight transmitter-delineated cell groups on each accompanying map. The emphasis throughout is on facilitating the identification of structures for those without advanced training in anatomy, enhanced by a comprehensive index of structures, abbreviations, temporal appearance, and spatial orientation to make pathfinding as easy as possible. With over 230 micrographs of superb quality, Chemical neuroanatomy of the prenatal rat brain: a developmental atlas will be an essential resource for all researchers in developmental and molecular neurobiology.
This atlas provides an accurate and detailed depiction of all brain structures at fetal stage E17.5, Day of birth, and Day 6 postnatal. In addition to brain structures, the atlas delineates peripheral nerves, ganglia, arteries, veins, muscles bones and other organs. It is an indispensable guide for the interpretation of nervous system changes in gene knockout and transgenic mice. Contains: 43 photographs and drawings of Nissl-stained coronal sections of the brain of a fetal mouse at E17.5 days, 65 photographs and drawings of Nissl-stained coronal sections of the brain of a mouse on the day of birth, and 73 photographs and drawings of Nissl-stained coronal sections of the brain of a mouse aged 6 days postnatal. The drawings are based on the study of sections stained with Nissl and a range of neuroactive substances. In addition to brain structures, the atlas delineates peripheral nerves, ganglia, arteries, veins, muscles bones and other organs.
Atlas of the Neonatal Rat Brain provides photographic, histological illustrations of the anatomical features of the neonatal rat brain at postnatal (P) days P-1, P-7, and P-14. The sections are Nissl stained with Cresyl violet, creating photomicrographs with high resolution and clarity. The structures are directly labeled on the images, making it easier to correlate data. Additional images are available as electronic resources for individuals who seek images not represented in this volume, and the electronic version allows labels to be removed so the atlas can be used as a teaching tool. The P-1 section contains 30 coronal plates and 14 sagittal plates and the P-7 section includes 27 coronal plates and 24 sagittal plates. The final P-14 section shows 41 coronal plates and 21 sagittal plates. Each set consists of contiguous sections from individual animals, and selections were based on the structural variability represented.
This third edition of the standard reference on the nervous system of the rat is a complete and updated revision of the 1994 second edition. All chapters have been extensively updated, and new chapters added covering early segmentation, growth factors, and glia. The book is now aligned with the data available in the Rat Brain in Stereotaxic Coordinates, making it an excellent companion to this bestselling atlas. Physiological data, functional concepts, and correlates to human anatomy and function round out the new edition. *Designed to be used in conjunction with the bestselling Rat Brain in Stereotaxic Coordinates *New to this edition is inclusion of physiological data, functional concepts, and correlates to human anatomy and function in each chapter *Contains new chapters on early segmentation of the central nervous system, growth factors and glia
Color images and annotated diagrams of: Gestational Days 12, 14, 16 and 18 Sagittal, coronal and horizontal section
Author: Uta Schambra
Publisher: Springer Science & Business Media
This is the only book available for studies of the mouse brain before birth. It presents a complete mapping of the developing mouse brain that features imaging of whole brain sections. Users will be able to compare structure shown in the Atlas to what they see in the microscope. This new, greatly expanded edition provides an easily accessible tool for researchers in the fields of normal and abnormal brain development.
Representing the state-of-the-art in neurochemical mapping, Chemoarchitectonic Atlas of the Developing Mouse Brain provides a complete, full-color look at the developing mouse brain. Hundreds of coronal sections are presented, clearly illustrating structures at progressive stages of brain development.
The Atlas of the Prenatal Mouse Brain is the latest addition to Academic Press' list of atlases for neuroscientists and neuroscience students. It fills an urgent need for a comprehensive atlas of the developing mouse brain for use in studies of both normal and abnormal development. High-quality photomicrographs of brain sections are depicted in sagittal, coronal, and horizontal planes for four gestational age groups. Each photomicrograph is accompanied by a fully labeled, precision-drawn diagram for easy identification of brain structures. Researchers and students using normal, transgenic, or mutant mouse preparations in developmental neurobiology, neurotoxicology, and biotechnology will welcome this meticulously assembled and accessible guide. Presents 153 photomicrographs of serial brain sections Represents four gestational ages (GD 12 and 14 embryos; GD 16 and 18 fetuses), each depicted in sigittal, coronal, and horizontal planes Includes fully labeled diagrams identifying brain structures for each photomicrograph Provides complete alphabetical lists of brain structures and abbreviations Presents a full description of tissue preparation method Large format, 8-1/2 x 11" pages in a sturdy hardcover case
Only five years ago, nobody in his right mind would have consid ered publishing a book on reeler as a model for brain develop ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation "reeler is reelin" has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.
Stereotaxic neurosurgery in rodents is used by a variety of people working at research laboratories (research staff, technicians, students at animal facilities...). The present handbook presents all the steps necessary to complete a stereotaxic neurosurgery protocol in accordance with current animal welfare guidelines. This book will guide surgeons step by step, from anesthesia to the post-surgery recovery procedures, including asepsis of the surgical tools and surgical zone, analgesia, correctly identifying the reference points on the skull and brain targets, etc. In keeping with the current international trends, the authors above all focus on the following points: the consideration of pain and how to best treat it depending on the type of surgery; and ensuring asepsis. This book will serve as an important reference work and valuable guidebook for the scientific community.