A Worldwide Perspective on Therapeutic Approaches and Their Molecular Basis
Author: Thomas Krieg
Publisher: Springer Science & Business Media
Based on the understanding of the molecular basis of skin diseases, this truly international book supports the reader to understand the mode of action of new and established therapies. Thus, by explaining the molecular pathology with its applications for therapy, it provides the reader with an up-to-date knowledge of the therapy of skin disease and helps to understand ongoing and new developments in the field. Written and edited by international and renowned dermatology experts from Europe, America and Asia, it also includes regional concepts of therapies. The reader-friendly structure allows the reader to pick up the information quickly; for example, each chapter highlights practical hints for indications and applications. This lavishly illustrated book will support the reader to choose the most appropriate therapy for the patient and to reach a better treatment outcome. It will be an indispensable resource for dermatologists in university departments as well as in clinical practice.
Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseases mechanisms. The second edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthritis, skin cancer, other common skin diseases, prostate cancer and migraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondylarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of human genetic disease and on animal models add important background on the omplexities of these diseases. Unique clinical applications of genetics to common diseases are covered in the additional new chapters on genetic counseling, pharmacogenetics, and the genetic consequences of modern therapeutics.
Dermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.
Get a quick, expert overview of alopecia with this concise, practical resource. Dr. Mariya Miteva covers high-interest clinical topics including hair cosmeceuticals, new medications in clinical trials, off-label treatment technologies, and much more. It’s an ideal resource for dermatologists, dermatopathologists, students, fellows, and researchers interested in hair loss. Presents rich visual information combined with expert opinions from the most renowned hair experts practicing today. Covers basic knowledge on healthy hair, hair pathology, and hair and scalp dermatoscopy (trichoscopy). Contains focused yet complete coverage of non-scarring alopecia, primary lymphocytic cicatricial alopecia, primary neutrophilic ciatricial alopecia, hair loss management, and miscellaneous hair disorders such as hair loss in children, hair and scalp infections, hair changes due to drugs, and more. Consolidates today’s available information and experience in this important area into one convenient resource.
NORD Guide to Rare Disorders is a comprehensive, practical, authoritative guide to the diagnosis and management of more than 800 rare diseases. The diseases are discussed in a uniform, easy-to-follow format--a brief description, signs and symptoms, etiology, related disorders, epidemiology, standard treatment, investigational treatment, resources, and references.The book includes a complete directory of orphan drugs, a full-color atlas of visual diagnostic signs, and a Master Resource List of support groups and helpful organizations. An index of symptoms and key words offers physicians valuable assistance in finding the information they need quickly.
Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The third edition has been thoroughly updated and extended by chapters on paraneoplastic cutaneous syndromes, atopic dermatitis and autoimmunity and Skin manifestations of rheumatic diseases.
Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects. The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.
Hair Loss Disorders in Domestic Animals is an in-depth reference on the pathomechanisms and clinical approaches of all skin diseases in domestic animals that have hair loss as the predominant clinical feature. It presents both basic and clinically-relevant knowledge on alopecic disease in animals. This text is a one-of-a-kind resource providing cutting-edge coverage of the physiology and pathology of hair follicles. Disease-specific chapters include: a detailed description of the disease entity, etiology, pathogenesis, clinical and histopathological diagnosis and treatment modalities.
Treatment of hair disorders has progressed considerably over time. More patients are now interested in hair care and some are bombarded by promising advertisements. In reality, hair disorders may be complex and require accurate diagnosis for suitable treatment.Hair Loss and Restoration provides an extensive look at the practical management, both me