*An Introduction for Biologists*

**Author**: Andy Hector

**Publisher:** Oxford University Press

**ISBN:**

**Category:** Science

**Page:** 199

**View:** 969

Statistical methods are a key tool for all scientists working with data, but learning the basic mathematical skills can be one of the most challenging components of a biologist's training. This accessible book provides a contemporary introduction to the classical techniques and modern extensions of linear model analysis: one of the most useful approaches in the analysis of scientific data in the life and environmental sciences. It emphasizes an estimation-based approach that accounts for recent criticisms of the over-use of probability values, and introduces alternative approaches using information criteria. Statistics are introduced through worked analyses performed in R, the free open source programming language for statistics and graphics, which is rapidly becoming the standard software in many areas of science and technology. These analyses use real data sets from ecology, evolutionary biology and environmental science, and the data sets and R scripts are available as support material. The book's structure and user friendly style stem from the author's 20 years of experience teaching statistics to life and environmental scientists at both the undergraduate and graduate levels. The New Statistics with R is suitable for senior undergraduate and graduate students, professional researchers, and practitioners in the fields of ecology, evolution, environmental studies, and computational biology.

R is rapidly becoming the standard software for statistical analyses, graphical presentation of data, and programming in the natural, physical, social, and engineering sciences. Getting Started with R is now the go-to introductory guide for biologists wanting to learn how to use R in their research. It teaches readers how to import, explore, graph, and analyse data, while keeping them focused on their ultimate goals: clearly communicating their data in oral presentations, posters, papers, and reports. It provides a consistent workflow for using R that is simple, efficient, reliable, and reproducible. This second edition has been updated and expanded while retaining the concise and engaging nature of its predecessor, offering an accessible and fun introduction to the packages dplyr and ggplot2 for data manipulation and graphing. It expands the set of basic statistics considered in the first edition to include new examples of a simple regression, a one-way and a two-way ANOVA. Finally, it introduces a new chapter on the generalised linear model. Getting Started with R is suitable for undergraduates, graduate students, professional researchers, and practitioners in the biological sciences.

An Introduction to Statistical Learning provides an accessible overview of the field of statistical learning, an essential toolset for making sense of the vast and complex data sets that have emerged in fields ranging from biology to finance to marketing to astrophysics in the past twenty years. This book presents some of the most important modeling and prediction techniques, along with relevant applications. Topics include linear regression, classification, resampling methods, shrinkage approaches, tree-based methods, support vector machines, clustering, and more. Color graphics and real-world examples are used to illustrate the methods presented. Since the goal of this textbook is to facilitate the use of these statistical learning techniques by practitioners in science, industry, and other fields, each chapter contains a tutorial on implementing the analyses and methods presented in R, an extremely popular open source statistical software platform. Two of the authors co-wrote The Elements of Statistical Learning (Hastie, Tibshirani and Friedman, 2nd edition 2009), a popular reference book for statistics and machine learning researchers. An Introduction to Statistical Learning covers many of the same topics, but at a level accessible to a much broader audience. This book is targeted at statisticians and non-statisticians alike who wish to use cutting-edge statistical learning techniques to analyze their data. The text assumes only a previous course in linear regression and no knowledge of matrix algebra.

Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated to address extremely complex biological questions. Correspondingly, advances in the statistical methods necessary to analyze such data are following closely behind the advances in data generation methods. The statistical methods required by bioinformatics present many new and difficult problems for the research community. This book provides an introduction to some of these new methods. The main biological topics treated include sequence analysis, BLAST, microarray analysis, gene finding, and the analysis of evolutionary processes. The main statistical techniques covered include hypothesis testing and estimation, Poisson processes, Markov models and Hidden Markov models, and multiple testing methods. The second edition features new chapters on microarray analysis and on statistical inference, including a discussion of ANOVA, and discussions of the statistical theory of motifs and methods based on the hypergeometric distribution. Much material has been clarified and reorganized. The book is written so as to appeal to biologists and computer scientists who wish to know more about the statistical methods of the field, as well as to trained statisticians who wish to become involved with bioinformatics. The earlier chapters introduce the concepts of probability and statistics at an elementary level, but with an emphasis on material relevant to later chapters and often not covered in standard introductory texts. Later chapters should be immediately accessible to the trained statistician. Sufficient mathematical background consists of introductory courses in calculus and linear algebra. The basic biological concepts that are used are explained, or can be understood from the context, and standard mathematical concepts are summarized in an Appendix. Problems are provided at the end of each chapter allowing the reader to develop aspects of the theory outlined in the main text. Warren J. Ewens holds the Christopher H. Brown Distinguished Professorship at the University of Pennsylvania. He is the author of two books, Population Genetics and Mathematical Population Genetics. He is a senior editor of Annals of Human Genetics and has served on the editorial boards of Theoretical Population Biology, GENETICS, Proceedings of the Royal Society B and SIAM Journal in Mathematical Biology. He is a fellow of the Royal Society and the Australian Academy of Science. Gregory R. Grant is a senior bioinformatics researcher in the University of Pennsylvania Computational Biology and Informatics Laboratory. He obtained his Ph.D. in number theory from the University of Maryland in 1995 and his Masters in Computer Science from the University of Pennsylvania in 1999. Comments on the first edition: "This book would be an ideal text for a postgraduate course...[and] is equally well suited to individual study.... I would recommend the book highly." (Biometrics) "Ewens and Grant have given us a very welcome introduction to what is behind those pretty [graphical user] interfaces." (Naturwissenschaften) "The authors do an excellent job of presenting the essence of the material without getting bogged down in mathematical details." (Journal American Statistical Association) "The authors have restructured classical material to a great extent and the new organization of the different topics is one of the outstanding services of the book." (Metrika)

Provides well-organized coverage of statistical analysis and applications in biology, kinesiology, and physical anthropology with comprehensive insights into the techniques and interpretations of R, SPSS®, Excel®, and Numbers® output An Introduction to Statistical Analysis in Research: With Applications in the Biological and Life Sciences develops a conceptual foundation in statistical analysis while providing readers with opportunities to practice these skills via research-based data sets in biology, kinesiology, and physical anthropology. Readers are provided with a detailed introduction and orientation to statistical analysis as well as practical examples to ensure a thorough understanding of the concepts and methodology. In addition, the book addresses not just the statistical concepts researchers should be familiar with, but also demonstrates their relevance to real-world research questions and how to perform them using easily available software packages including R, SPSS®, Excel®, and Numbers®. Specific emphasis is on the practical application of statistics in the biological and life sciences, while enhancing reader skills in identifying the research questions and testable hypotheses, determining the appropriate experimental methodology and statistical analyses, processing data, and reporting the research outcomes. In addition, this book: • Aims to develop readers’ skills including how to report research outcomes, determine the appropriate experimental methodology and statistical analysis, and identify the needed research questions and testable hypotheses • Includes pedagogical elements throughout that enhance the overall learning experience including case studies and tutorials, all in an effort to gain full comprehension of designing an experiment, considering biases and uncontrolled variables, analyzing data, and applying the appropriate statistical application with valid justification • Fills the gap between theoretically driven, mathematically heavy texts and introductory, step-by-step type books while preparing readers with the programming skills needed to carry out basic statistical tests, build support figures, and interpret the results • Provides a companion website that features related R, SPSS, Excel, and Numbers data sets, sample PowerPoint® lecture slides, end of the chapter review questions, software video tutorials that highlight basic statistical concepts, and a student workbook and instructor manual An Introduction to Statistical Analysis in Research: With Applications in the Biological and Life Sciences is an ideal textbook for upper-undergraduate and graduate-level courses in research methods, biostatistics, statistics, biology, kinesiology, sports science and medicine, health and physical education, medicine, and nutrition. The book is also appropriate as a reference for researchers and professionals in the fields of anthropology, sports research, sports science, and physical education. KATHLEEN F. WEAVER, PhD, is Associate Dean of Learning, Innovation, and Teaching and Professor in the Department of Biology at the University of La Verne. The author of numerous journal articles, she received her PhD in Ecology and Evolutionary Biology from the University of Colorado. VANESSA C. MORALES, BS, is Assistant Director of the Academic Success Center at the University of La Verne. SARAH L. DUNN, PhD, is Associate Professor in the Department of Kinesiology at the University of La Verne and is Director of Research and Sponsored Programs. She has authored numerous journal articles and received her PhD in Health and Exercise Science from the University of New South Wales. KANYA GODDE, PhD, is Assistant Professor in the Department of Anthropology and is Director/Chair of Institutional Review Board at the University of La Verne. The author of numerous journal articles and a member of the American Statistical Association, she received her PhD in Anthropology from the University of Tennessee. PABLO F. WEAVER, PhD, is Instructor in the Department of Biology at the University of La Verne. The author of numerous journal articles, he received his PhD in Ecology and Evolutionary Biology from the University of Colorado.

Computer software is an essential tool for many statistical modelling and data analysis techniques, aiding in the implementation of large data sets in order to obtain useful results. R is one of the most powerful and flexible statistical software packages available, and enables the user to apply a wide variety of statistical methods ranging from simple regression to generalized linear modelling. Statistics: An Introduction using R is a clear and concise introductory textbook to statistical analysis using this powerful and free software, and follows on from the success of the author's previous best-selling title Statistical Computing. * Features step-by-step instructions that assume no mathematics, statistics or programming background, helping the non-statistician to fully understand the methodology. * Uses a series of realistic examples, developing step-wise from the simplest cases, with the emphasis on checking the assumptions (e.g. constancy of variance and normality of errors) and the adequacy of the model chosen to fit the data. * The emphasis throughout is on estimation of effect sizes and confidence intervals, rather than on hypothesis testing. * Covers the full range of statistical techniques likely to be need to analyse the data from research projects, including elementary material like t-tests and chi-squared tests, intermediate methods like regression and analysis of variance, and more advanced techniques like generalized linear modelling. * Includes numerous worked examples and exercises within each chapter. * Accompanied by a website featuring worked examples, data sets, exercises and solutions: http://www.imperial.ac.uk/bio/research/crawley/statistics Statistics: An Introduction using R is the first text to offer such a concise introduction to a broad array of statistical methods, at a level that is elementary enough to appeal to a broad range of disciplines. It is primarily aimed at undergraduate students in medicine, engineering, economics and biology - but will also appeal to postgraduates who have not previously covered this area, or wish to switch to using R.

This illustrated textbook for biologists provides a refreshingly clear and authoritative introduction to the key ideas of sampling, experimental design, and statistical analysis. The author presents statistical concepts through common sense, non-mathematical explanations and diagrams. These are followed by the relevant formulae and illustrated by worked examples. The examples are drawn from all areas of biology, from biochemistry to ecology and from cell to animal biology. The book provides everything required in an introductory statistics course for biology undergraduates, and it is also useful for more specialized undergraduate courses in ecology, botany, and zoology.

Since 1975, The Analysis of Time Series: An Introduction has introduced legions of statistics students and researchers to the theory and practice of time series analysis. With each successive edition, bestselling author Chris Chatfield has honed and refined his presentation, updated the material to reflect advances in the field, and presented interesting new data sets. The sixth edition is no exception. It provides an accessible, comprehensive introduction to the theory and practice of time series analysis. The treatment covers a wide range of topics, including ARIMA probability models, forecasting methods, spectral analysis, linear systems, state-space models, and the Kalman filter. It also addresses nonlinear, multivariate, and long-memory models. The author has carefully updated each chapter, added new discussions, incorporated new datasets, and made those datasets available for download from www.crcpress.com. A free online appendix on time series analysis using R can be accessed at http://people.bath.ac.uk/mascc/TSA.usingR.doc. Highlights of the Sixth Edition: A new section on handling real data New discussion on prediction intervals A completely revised and restructured chapter on more advanced topics, with new material on the aggregation of time series, analyzing time series in finance, and discrete-valued time series A new chapter of examples and practical advice Thorough updates and revisions throughout the text that reflect recent developments and dramatic changes in computing practices over the last few years The analysis of time series can be a difficult topic, but as this book has demonstrated for two-and-a-half decades, it does not have to be daunting. The accessibility, polished presentation, and broad coverage of The Analysis of Time Series make it simply the best introduction to the subject available.

This is the third edition of a successful textbook, now with material added to illustrate the potential of computers for biologists. It is a lucid introduction to the principles and more elementary techniques of statistical reasoning, particularly as they are relevant to the biologist. Special attention is paid to the validity and use of statistical procedures, the interpretation of results, and the meanings of the conclusions which can then be drawn. The understanding of statistical methods is aided by full explanations of how calculations are built up. A particular feature of this edition is the inclusion, of new material to demonstrate the potential usefulness of computers in biological statistical analysis and to this end computer analyses of a selection of the examples are presented, using several different statistical languages. The examples are designed to guide and encourage the biologist to pursue the use of these languages further. The book assumes no mathematical training and uses a minimum of jargon and symbolism. It will be useful to any biologist, student or research worker who needs an introduction to statistical procedures.