How Genetic Technologies Are Changing the Way We Have Kids--and the Kids We Have
Author: Bonnie Rochman
Publisher: Scientific American / Farrar, Straus and Giroux
Category: Family & Relationships
A sharp-eyed exploration of the promise and peril of having children in an age of genetic tests and interventions Is screening for disease in an embryo a humane form of family planning or a slippery slope toward eugenics? Should doctors tell you that your infant daughter is genetically predisposed to breast cancer? If tests revealed that your toddler has a genetic mutation whose significance isn’t clear, would you want to know? In The Gene Machine, the award-winning journalist Bonnie Rochman deftly explores these hot-button questions, guiding us through the new frontier of gene technology and how it is transforming medicine, bioethics, health care, and the factors that shape a family. Rochman tells the stories of scientists working to unlock the secrets of the human genome; genetic counselors and spiritual advisers guiding mothers and fathers through life-changing choices; and, of course, parents (including Rochman herself) grappling with revelations that are sometimes joyous, sometimes heartbreaking, but always profound. She navigates the dizzying and constantly expanding array of prenatal and postnatal tests, from carrier screening to genome sequencing, while considering how access to more tests is altering perceptions of disability and changing the conversation about what sort of life is worth living and who draws the line. Along the way, she highlights the most urgent ethical quandary: Is this technology a triumph of modern medicine or a Pandora’s box of possibilities? Propelled by human narratives and meticulously reported, The Gene Machine is both a scientific road map and a meditation on our power to shape the future. It is a book that gets to the very core of what it means to be human.
How Genetic Technologies Are Changing the Way We Have Kids--and the Kids We Have
Author: Bonnie Rochman
Publisher: Scientific American / Farrar, Straus and Giroux
A sharp-eyed exploration of the promise and peril of having children in an age of genetic tests and interventions Is DNA testing a triumph of modern medicine or a Pandora’s box of possibilities? Is screening for disease in an embryo a humane form of family planning or a slippery slope toward eugenics? And, more practically, how do we navigate the dizzying and expanding array of tests available, with more appearing every day? In The Gene Machine, the award-winning journalist Bonnie Rochman addresses these questions and more, guiding us through the new frontiers of gene technology and how it has forever changed medicine, bioethics, and the factors that shape a family. Rochman takes an authoritative look at the latest hot-button issues in the world of pre- and postnatal testing and tells the stories of women and men struggling to understand the variety of tests and grappling with their results—revelations that are sometimes joyous, sometimes heartbreaking, and often profound. Propelled by human narratives and meticulously reported, The Gene Machine introduces us to scientists working to unlock the secrets of the human genome; gene counselors and spiritual advisers helping parents manage this complex new reality; and, of course, parents themselves, including the author, who glimpse the genetic futures of their children. The Gene Machine is both a scientific road map and a meditation on our power to shape the future, one that gets to the very core of what it means to be human.
A Nobel Prize-winning biologist tells the riveting story of his race to discover the inner workings of biology's most important molecule "Ramakrishnan's writing is so honest, lucid and engaging that I could not put this book down until I had read to the very end."--Siddhartha Mukherjee, author of The Emperor of All Maladies and The Gene Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.
America's Leading Physicians Share Stories They Can't Forget
Author: Harley A. Rotbart
Publisher: Health Communications, Inc.
This is a book of miracles--medical events witnessed by leading physicians for which there is no reasonable medical explanation, or, if there is, the explanation itself is extraordinary. These dramatic first-person essays detail spectacular serendipities, impossible cures, breathtaking resuscitations, extraordinary awakenings, and recovery from unimaginable disasters. Still other essays give voice to cases in which the physical aspects were less dramatic than the emotional aspects, yet miraculous and transformational for everyone involved. Positive impacts left in the wake of even the gravest of tragedies, profound triumphs of heart and spirit. Preeminent physicians in many specialties, including deans and department heads on the faculties of the top university medical schools in the country describe, in everyday language and with moving testimony, their very personal reactions to these remarkable clinical experiences. Among the extraordinary cases poignantly recounted by the physicians witnessing them: A priest visiting a hospitalized patient went into cardiac arrest on the elevator, which opened up on the cardiac floor, right at the foot of the cardiac specialist, at just the right moment. A tiny premature baby dying from irreversible lung disease despite the most intensive care who recovered almost immediately after being taken from his hospital bed and placed on his mother's chest. President John F. Kennedy's son Patrick, who died shortly after birth, and whose disease eventually led to research that saved generations of babies. A nine-year-old boy who was decapitated in a horrific car accident but survived without neurological damage. A woman who conceived and delivered a healthy baby--despite having had both of her fallopian tubes surgically removed. A young man whose only hope for survival was a heart transplant, but just at the moment he developed a potentially fatal complication making a transplant impossible, his own heart began healing itself. A teenage girl near death after contracting full-blown rabies who became the first patient ever to recover from that disease after an unexpected visit by Timothy Dolan, the man who would go on to become the Archbishop of New York. A Manhattan window-washer who fell 47 stories--and not only became the only person ever to survive a fall from that height, but went on to make a full recovery. Miracles We Have Seen is a book of inspiration and optimism, and a compelling glimpse into the lives of physicians--their humanity and determined devotion to their patients and their patients' families. It reminds us that what we don't know or don't understand isn't necessarily cause for fear, and can even be reason for hope.
If you were diagnosed with a condition for which there was no known cure, what would you do? Nick Duerden is a writer and journalist. This is his memoir about a long period of ill health, and how he was forced to plunge, like it or not, into the often bewildering – but increasingly blossoming – world of alternative therapy in pursuit of a cure. He followed strictly regimented, vitamin-rich diets, and swallowed all manner of supplements. He smeared himself in coarse mineral salts, and grew tepid in Epsom salt baths. He visited energy practitioners and spiritual gurus. He learned yoga, how to meditate, to breathe properly, to face his fears and manage the new anxieties those very fears had done so well to engender. Over the course of three years, Nick's lifelong cynicism is gradually replaced by an open eagerness to try anything, if not quite everything and in doing so, he starts on the road back to health. Get Well Soon is a memoir that focuses on the journey all of us will at some point have to face: the abrupt obligation to start living better, wiser, healthier, to be kinder to our minds and bodies by realising that minds and bodies do require care. It's about what happens to life when you become ill, because everyday life is never going to stop going about its chaotic business. This is not a self-help book. But it is, in its own candid, unflinching and stumbling way, a mapless guide to belatedly learning to live well, to negotiating a very particular, and all too common, midlife crisis. It is honest, and funny, and ultimately optimistic. And it might just offer proof that self-discovery, even when it is enforced self-discovery, is no bad thing.
The promise and peril of having children in an age of genetic tests and interventions. The must-read summary of "The Gene Machine: How Genetic Technologies Are Changing the Way We Have Kids - and the Kids We Have" by Bonnie Rochman. This complete summary of Rochman's book covers a variety of topics from breast cancer to Tay-Sachs, several pre-natal genetic mapping technologies, genome sequencing, rare disease diagnosis, silencing of a gene, and repairing gene defects using gene editing tools (CRISPR). It covers the question of testing for Down syndrome and abortion, and the emotionally and morally fraught decisions individuals are forced to make when confronting the information these tests reveal. In the past few years, genetic testing has expanded into a full array of testing available prenatally, postnatally, and even pre-conception. More targeted analysis has allowed women to weed out unhealthy embryos before attempting pregnancy. Genome sequencing gives the child's blueprint, including predisposition to diseases such as Down syndrome, early-onset Alzheimer's, or breast cancer. Having access to so much information can be empowering, enlightening, confusing, and frightening. It can enable parents to prepare for a child with special needs. Or it can allow them to end the pregnancy. This guide includes: Book Summary-The summary helps you understand the key ideas and recommendations. Online Videos-On-demand replay of public lectures, and seminars on the topics covered in the chapter. Value-added of this guide: Save time Understand key concepts Expand your knowledge This is a must read for those planning on having kids, or for those who simply want to learn about genetic technologies. Tags: gene; genetics; CRISPR; sequencing; DNA sequencing; selective abortion; prenatal diagnosis; prenation genetic diagnosis; IVF; in vitro fertilization; down syndrome; trisomy; tay-sachs; abortion; ashkenazi jews; brca; brca1; carrier screening; chromosomal microarray analysis; chromosome; comprehensive chromosome screening; chorionic villus sampling; amniocentesis; celiac disease; gluten; genetic testing;dna; eugenic; genetic mutation; genome sequencing; mendelian; rare disease; prenatal therapy; preimplantation genetic diagnosis; severe combined immunodeficienc; scid; volnereable child syndrome; designer baby; germline editing; genetic engineering;
The Remarkable, Completely Misunderstood Relationship Between You and Your Genes
Author: Steven J. Heine
Publisher: W. W. Norton
Category: Health & Fitness
"Do you fear what might be lurking in your DNA? Well, now you can find out, and you most likely will. Scientists expect one billion people to have their genomes sequenced by 2025, and as the price drops it may even become a standard medical procedure. Yet cultural psychologist Steven J. Heine argues that the first thing we'll do upon receiving our DNA test results is to misinterpret them completely. We've become accustomed to breathless media coverage about newly discovered "cancer" or "IQ" or "infidelity" genes, each one promising a deeper understanding of what makes us tick. But as Heine shows, most of these claims are oversimplified and overhyped misinterpretations of how our DNA really works. With few exceptions, it is a complex combination of experience, environment, and genetics that determines who we are, how we behave, and what diseases will afflict us in the future. So why do we continue to buy into the belief that our genes control our destiny? Heine argues that we are psychologically ill equipped to deal with DNA results, repeatedly falling into predictable biases--switch-thinking, essentialism, fatalism, negativity dominance, and more--that mold our thinking about the information we receive. Heine shares his research--and his own genome-sequencing results--not only to set the record straight regarding what your genes actually reveal about your health, intelligence, ethnic identity, and family, but also to help you counteract these insidious cognitive traps. His fresh, surprising conclusions about the promise, and limits, of genetic engineering and DNA testing upend conventional thinking and reveal a simple, profound truth: your genes create life--but they do not control it."--Jacket.
In this book: Donna Dickenson - Winner of the International Spinoza Lens Award Should we do what ever science lets us do?Bioethics: All That Matters, new developments in biotechnology like genetics, stem cell research and artificial reproduction arouse both our greatest hopes and our greatest fears. Many people invest the new biotechnology with all the aspirations and faith once accorded to religious salvation. But does everyone benefit equally from scientific progress? Commercialised modern biomedicine runs the risk of exploiting vulnerable groups, from Indian 'surrogate' mothers to professional guinea pigs in drug research. Professor Dickenson argues that although we've entered new scientific territory, there's no need to jettison our existing moral sense. By discussing a range of real-life cases, she equips readers to make up their own minds on these important and controversial questions. Good science and good ethics needn't be contradictory. This accessible and concise book will appeal to both students and general readers, giving a fascinating introduction to a wide range of perspectives on Bioethics. All That Matters books: All books in the All That Matters series are written by world experts in their subject field. These experts work to distil a topic and get right to its heart, making the book accessible for both students and general readers. Each compelling book contains new and interesting perspectives and tells stories that matter. The Author: All That Matters - Interesting introductions to important issues Books on the following subjects are available from the All That Matters series: Muhammad, God, Water, Political Philosophy, Sustainability, Philosophy, Intelligence, Love, Russian Revolution, War, and Creativity.To find out more visit: www.allthatmattersbooks.com
"This funny, candid memoir about the author's intern year at a New York hospital provides a scorchingly frank look at how doctors are made, taking readers into the critical care unit to see one burgeoning physician's journey from ineptitude to competence. After his professional baseball career failed to launch, Matt McCarthy went to Harvard Medical School and on to a coveted residency slot in New York. But when he almost lost a patient on his first day after making what he believed to be a terrible error, he found himself facing the harsh reality of a new doctor's life--one in which even overachievers find themselves humbled, and in which med school training has little to offer in navigating the emotional rollercoaster of dealing with actual patients. Luckily for McCarthy, his second-year-resident adviser (whom he calls "Baio," owing to a resemblance to a Charles in Charge-era Scott Baio) was an offbeat genius, with a knack for breaking down the complicated process of treating patients. But neither doctor could offer much help to a patient named Barney, who had been living in the hospital while waiting for a new heart, and whom McCarthy slowly befriended over the course of the year in ways that changed his perception of what it means to be a physician. Mixing the tense drama of ER with the screwball humor of Scrubs, McCarthy offers a window on to hospital life that dispenses with sanctimony and self-seriousness while emphasizing the black-comic paradox of becoming a doctor: How do you learn how to save lives in a job where there is no practice? This "One L for doctors" will inspire and entertain physicians and patients alike"--
"When Damon Tweedy first enters the halls of Duke University Medical School on a full scholarship, he envisions a bright future where his segregated, working class background will become largely irrelevant. Instead, he finds that he has joined a new world where race is front and center. When one of his first professors mistakes him for a maintenance worker, it is a moment that crystallizes the challenges he will face throughout his early career. Making matters worse, in lecture after lecture the common refrain for numerous diseases resounds: "more common in blacks than whites." [This book] examines the complex ways in which both black doctors and patients must navigate the difficult and often contradictory terrain of race and medicine"--
Dr. Steven Hatch first came to Liberia in November 2013, to work at a hospital in Monrovia. Six months later, several of the physicians Dr. Hatch had mentored and served with were dead or barely clinging to life, and Ebola had become a world health emergency. Hundreds of victims perished each week; whole families were destroyed in a matter of days; so many died so quickly that the culturally taboo practice of cremation had to be instituted to dispose of the bodies. With little help from the international community and a population ravaged by disease and fear, the war-torn African nation was simply unprepared to deal with the catastrophe. A physician’s memoir about the ravages of a terrible disease and the small hospital that fought to contain it, Inferno is also an explanation of the science and biology of Ebola: how it is transmitted and spreads with such ferocity. And as Dr. Hatch notes, while Ebola is temporarily under control, it will inevitably re-emerge—as will other plagues, notably the Zika virus, which the World Health Organization has declared a public health emergency. Inferno is a glimpse into the white-hot center of a crisis that will come again.
As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.
A Story of Hope, a Family's Genetic Destiny, and the Science That Rescued Them
Author: Gina Kolata
Publisher: St. Martin's Press
"[Kolata] is a gifted storyteller. Her account of the Baxleys... is both engrossing and distressing... Kolata's book raises crucial questions about knowledge that can be both vital and fatal, both pallative and dangerous." —Andrew Solomon, The New York Review of Books New York Times science reporter Gina Kolata follows a family through genetic illness and one courageous daughter who decides her fate shall no longer be decided by a genetic flaw. The phone rings. The doctor from California is on the line. “Are you ready Amanda?” The two people Amanda Baxley loves the most had begged her not to be tested—at least, not now. But she had to find out. If your family carried a mutated gene that foretold a brutal illness and you were offered the chance to find out if you’d inherited it, would you do it? Would you walk toward the problem, bravely accepting whatever answer came your way? Or would you avoid the potential bad news as long as possible? In Mercies in Disguise, acclaimed New York Times science reporter and bestselling author Gina Kolata tells the story of the Baxleys, an almost archetypal family in a small town in South Carolina. A proud and determined clan, many of them doctors, they are struck one by one with an inscrutable illness. They finally discover the cause of the disease after a remarkable sequence of events that many saw as providential. Meanwhile, science, progressing for a half a century along a parallel track, had handed the Baxleys a resolution—not a cure, but a blood test that would reveal who had the gene for the disease and who did not. And science would offer another dilemma—fertility specialists had created a way to spare the children through an expensive process. A work of narrative nonfiction, Mercies in Disguise is the story of a family that took matters into its own hands when the medical world abandoned them. It’s a story of a family that had to deal with unspeakable tragedy and yet did not allow it to tear them apart. And it is the story of a young woman—Amanda Baxley—who faced the future head on, determined to find a way to disrupt her family’s destiny.
100 kid-friendly projects from the creator of C.R.A.F.T.! Get ready for some serious family fun! Filled with 100 fun crafts, Creating Really Awesome Free Things helps you develop your child's creativity, imagination, and fine motor skills--all while using common household items. Each budget-friendly project features step-by-step instructions and keeps kids entertained, engaged, and learning all day long. You and your children will love recreating one-of-a-kind crafts like: Memory Game Egg Carton Flowers Key Wind Chime Ring Toss Lion Mask Complete with photographs for every project, Creating Really Awesome Free Things promotes hours of playtime fun with the entire family!
Gene Editing and the Unthinkable Power to Control Evolution
Author: Jennifer A. Doudna,Samuel H. Sternberg
Publisher: Houghton Mifflin Harcourt
Finalist for the Los Angeles Times Book Prize One of Science News’ Favorite Books of the Year “Required reading for every concerned citizen.” — New York Review of Books “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “An essential start to educating the public . . . reveal[s] the complex, interlocking, and thoroughly international nature of today’s bioscience.” —Los Angeles Review of Books “An invaluable account . . . We owe Doudna several times over.” — Guardian
The author of A Life Decoded explains how his team's achievement with sequencing the human genome has launched an important age of biological research, revealing a growing potential for enabling humans to adapt and evolve for long-term survival and environmental improvement.
Redesigning the Future of Humanity - One Gene at a Time
Author: Juan Enriquez,Steve Gullans
"Futurist Juan Enriquez and scientist Steve Gullans conduct a sweeping tour of how humans are changing the course of evolution for all species--sometimes intentionally, sometimes not. For example: What if life forms are limited only by the bounds of our imagination? Are designer babies and pets, de-extinction, even entirely newspecies fair game?; As humans, animals, and plants become ever more resistant to disease and aging, what will become the leading causes of death?; Man-machine interfaces may allow humans to live much longer. What will happen when we transfer parts of our 'selves' into clones, into stored cells and machines? Though these harbingers of change are deeply unsettling, the authors argue we are also in an epoch of tremendous opportunity. Future humans, perhaps a more diverse, resilient, gentler, and intelligent species, may become better caretakers of the planet--but only if we make the right choices now."--Provided by publisher.
. The book that takes a comprehensive look at the threat to our food supply from genetic engineering. . 15,000 copies sold in the first six months. . Includes new studies about the dangers of genetically engineered food. . Refutes the "feed the poor" propaganda spread by agribusinesses. . Is both an expose and educational primer on this controversial technology that is already a part of every American's diet. . Explains the dangers of these foods to ourselves and our environment in easily understood terms. Picture a world? . Where the french fries you eat are registered as a pesticide, not a food. . Where vegetarians unwittingly consume fish genes in their tomatoes. . Where corn plants kill monarch butterflies. . Where soy plants thrive on doses of herbicide that kill every other plant in sight. . Where multinational corporations own the life forms that farmers grow and legally control the farmers' actions. That world exists These things are all happening, and they are happening to you. Genetically engineered foods--plants whose genetic structures are altered by scientists in ways that could never occur in nature--are already present in many of the products you buy in supermarkets, unlabeled, unwanted, and largely untested. The threat of these organisms to human and environmental health has caused them to be virtually banned in Europe, yet the U.S. government, working hand-in-hand with a few biotech corporations, has actively encouraged their use while discouraging labeling that might alert consumers to what they are eating. The authors show what the future holds and give you the information you need to preserve the independence and integrity of our food supply. What can you do? First, inform yourself. Genetically Engineered Food: Changing the Nature of Nature is the first book to take a comprehensive look at the many ramifications of this disturbing trend. Authors Martin Teitel and Kimberly Wilson explain what genetic engineering is and how it works, then explore the health risks involved with eating organisms never before seen in nature. They address the ecological catastrophe that could result from these modified plants crossing with wild species and escaping human control altogether, as well as the economic devastation that may befall small farmers who find themselves at the mercy of mega-corporations for their livelihood. Taking the discussion a step further, they consider the ethical and spiritual implications of this radical change in our relationship to the natural world, showing what the future holds and giving you the information you need to act on your own or to join others in preserving the independence and integrity of our food supply.