die völkerrechtliche Zulässigkeit der gezielten Tötung von Terroristen im Ausland
Author: Heiko F. Schmitz-Elvenich
Publisher: Peter Lang
Das Thema der -Gezielten Totung von Terroristen- ist aufgrund der jungsten Entwicklungen in der internationalen Terrorismusbekampfung von hochster Aktualitat. Insbesondere der von der US-Administration ausgerufene -Krieg gegen den Terror- und das israelische Vorgehen gegen palastinensische Extremisten haben eine intensive volkerrechtliche Diskussion in Gang gesetzt. Der Verfasser nimmt sich der vielschichtigen, eine ganze Reihe von Grundfragen des Volkerrechts beruhrenden Problematik an, um die politische Diskussion mit einer wissenschaftlich-volkerrechtlichen Analyse zu unterlegen. Er beleuchtet dabei im Schwerpunkt das UN-Chartarecht im Hinblick auf das Gewaltverbot und das volkerrechtliche Selbstverteidigungsrecht, widmet sich aber auch dem humanitaren Volkerrecht und dem internationalen Menschenrechtsschutz."
How Technology Is Revolutionizing Advertising and the Way Companies Reach Consumers
Author: Mike Smith
Publisher: AMACOM Div American Mgmt Assn
Category: Business & Economics
Far from the catchy television spots and sleek magazine spreads are the comparatively modest ads that pop up on websites and in Internet searches. But don’t be fooled—online advertising is exploding. Growing at a compound annual rate near 20%, it is now the second-largest advertising channel in the United States. Part history, part guidebook, part prediction for the future, Targeted tells the story of the companies, individuals, and innovations driving this revolution. It takes readers behind the scenes—examining the growth of digital advertising, its enormous potential, and the technologies that are changing the game forever. Leading the way is real-time bidding, which offers advertisers unprecedented precision in targeting ads and measuring their effectiveness. From keyword micro-markets and ad serving systems to aggregated virtual audiences and new business models, Targeted is sweeping in scope and stripped of technical complexity. It is an essential resource for anyone interested in finding and connecting with customers in the vast and shifting Internet universe.
Die Arbeit befasst sich mit der Untersuchung des Zusammenwirkens der Bereiche des humanitaren Volkerrechts und der Menschenrechte bezogen auf sogenannte "targeted killings," also gezielten Totungen von Mitgliedern nichtstaatlicher Kampfverbande durch einen Staat. Das "targeted killing" beruhrt einerseits das Recht auf Leben im Bereich der Menschenrechte und andererseits die Regeln zum Einsatz todlicher Gewalt im humanitaren Volkerrecht. Deshalb stellt es auch eine Schnittstelle der beiden Rechtsgebiete dar, deren Zusammenspiel noch immer nicht endgultig geklart ist. Hieran werden die Probleme der rechtlichen Einordnung von Massnahmen der internationalen Terrorismusbekampfung in den Rahmen des Volkerrechts aufgezeigt. Konnen gezielte Totungen von Mitgliedern internationaler terroristischer Organisationen durch einen Staat als legale Angriffsmittel nach dem Recht der bewaffneten Konflikte gelten? Oder sollten doch nur polizei- oder strafrechtliche Methoden und keine militarische Gewalt angewandt werden? Am Beispiel des "targeted killing" soll geklart werden, ob das bisherige System von Menschenrechten und humanitarem Volkerrecht dem internationalen Terrorismus und seiner Bekampfung Grenzen aufweisen kann, ohne die Effektivitat der Bekampfung gravierend zu behindern."
Emerging technologies in target identification, drug discovery, molecular markers, and imaging are rapidly changing the face of cancer. This book provides a foundation of knowledge in targeted cancer therapeutics. The treatment of cancer is increasingly being individualized, based on an understanding of underlying biologic mechanisms. Poised to change the landscape in oncology, this volume provides a state-of-the-art overview. It will be valuable to practicing and academic physicians, fellows, residents and students, as well as basic scientists, interested in the cancer field.
Author: Torgny Stigbrand,Jorgen Carlsson,Gregory P. Adams
Publisher: Springer Science & Business Media
The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.
For San Diego's elite FBI agents, risking their lives is standard procedure when it comes to capturing the city's most dangerous criminals-but falling in love is the greatest risk of all. RIPPED FROM THE HEADLINES . . . FBI Special Agent Marissa Panuska faces the most explosive case of her career when she impersonates a female terrorist to infiltrate an al-Qaeda cell. Her dark hair, olive complexion, and Arabic fluency make her the perfect imposter, but each passing hour raises the risk of discovery. Can she stop the dirty-bomb plot-alone-when the Feds don't even know the target? And should she trust the mysterious man who bursts into her life when her cover is blown? SO CLOSE TO REALITY . . . Former Navy SEAL Ameen Ali has a very personal reason for hating the terrorists and vowing to stop them. But when a beautiful woman joins the sleeper cell spreading death-to-America propaganda at his mosque, he doesn't want to believe she shares their evil goals. Can he convince her to join forces before it's too late?
Targeted therapy is one of the most burgeoning areas of development in cancer research. Increasing knowledge in tumor formation and growth at the molecular level has generated a broad array of therapeutic options, including signal transduction inhibition, anti-angiogenic and anti-vascular agents, cell cycle inhibitors, telomerase and telomere interacting agents, apoptosis inducers, and anti-invasive agents. This book presents an authoritative overview of existing molecular targeted therapies, their relevance and role for specific tumors, and their clinical efficacy and impact on patient treatment.
This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.
Liz Sherman, a hardworking Canadian, doesnt like what she sees in todays society. Much of the world caters to the well-off, and most average and low-income people find themselves shopping at second-hand stores, where prices continue to increase. Meanwhile, there is more anxiety than ever about obtaining worldly goods, with stress being taken on for appearancesnot by necessity. But perhaps nothing is more frustrating than insurance companies, which have turned cheating hardworking people out of rightful claims into a science. In Targeted, the author shares how she battled insurance companies for almost nine years to get the settlement she deservedand she also examines the myriad other ways that society abuses everyday people. When Shermans legal battle finally ended, it was a sad victory, as she owed relatives and friends money and had suffered tremendous amounts of stress. She shares her inspiring story and argues that Canadians need a regulating agent to eradicate insurance company-sponsored fraud in this book.
Michael H. Weisman, Michael Weinblatt, James S Louie, and Ronald Van Vollenhoven offer their unique insights into choosing the correct pharmacological and non-pharmacological therapies for your patients. Chapters cover the full breadth of rheumatic diseases, rheumatoid arthritis, lupus, connective tissue diseases, osteoporosis, regional pain disorders, and fibromyalgia. The full-color design presents detailed clinical photographs and treatment algorithms for visual guidance and easy reference. Covers the treatment of pediatric patients as well as adults so that you can properly address the particular needs of any patient you see. Features the guidance and specific recommendations of experts from United States and Europe for a state-of-the-art approach to the variety of treatments currently in use. Displays the clinical manifestations of rheumatic diseases in full color, along with treatment algorithms for easy at-a-glance reference.
Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
Alexander F. Vakakis,Oleg V. Gendelman,Lawrence A. Bergman,D. Michael McFarland,Gaëtan Kerschen,Young Sup Lee
Author: Alexander F. Vakakis,Oleg V. Gendelman,Lawrence A. Bergman,D. Michael McFarland,Gaëtan Kerschen,Young Sup Lee
Publisher: Springer Science & Business Media
Category: Technology & Engineering
This monograph evolved over a period of nine years from a series of papers and presentations addressing the subject of passive vibration control of mechanical s- tems subjected to broadband, transient inputs. The unifying theme is Targeted - ergy Transfer – TET, which represents a new and unique approach to the passive control problem, in which a strongly nonlinear, fully passive, local attachment, the Nonlinear Energy Sink – NES, is employed to drastically alter the dynamics of the primary system to which it is attached. The intrinsic capacity of the properly - signed NES to promote rapid localization of externally applied (narrowband) - bration or (broadband) shock energy to itself, where it can be captured and dis- pated, provides a powerful strategy for vibration control and the opens the pos- bility for a wide range of applications of TET, such as, vibration and shock i- lation, passive energy harvesting, aeroelastic instability (?utter) suppression, se- mic mitigation, vortex shedding control, enhanced reliability designs (for ex- ple in power grids) and others. The monograph is intended to provide a thorough explanation of the analytical, computational and experimental methods needed to formulate and study TET in mechanical and structural systems. Several prac- cal engineering applications are examined in detail, and experimental veri?cation and validation of the theoretical predictions are provided as well. The authors also suggest a number of possible future applications where application of TET seems promising. The authors are indebted to a number of sponsoring agencies.
This book does nothing less than lay out the state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities. The sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to derive more efficient cancer drugs?
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
Terrorists are attacking airliners using an unknown weapon that one surviving passenger described as a "missile with wings." Deaths and injuries are in the hundreds. Rumors of extraterrestrial visitors have the public in a panic. People are afraid to set foot on an airliner. Experts wonder if TWA 800 might have been the first of the attacks. The airline business is in danger of folding unless the terrorists are caught. An ex air traffic controller turned lawyer, Kyle Matthews, a man the FAA once wanted to fire, is asked to investigate. But when Air Force One is attacked, and pieces of the weapon are found in the cockpit, Matthews realizes that no terrorist group would have the resources to fund such a weapon. He shifts the focus of his investigation to one of several government agency heads, and narrows his suspects down to one particular official who he feels is stonewalling him. Matthews sets a trap to force his suspect to confess. After boarding the flight, the suspect is led to believe that the flight is about to be shot down. The suspect confesses, but the flight is attacked anyway.
This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.
Billions of dollars are spent every year on research into targeted therapies for cancer. That’s why it’s more than ever crucial for the thousands of scientists working in the field to keep right up to date with the cutting edge. This fascinating collection of material goes a long way to helping them do so, featuring as it does contributions to a crucial international meeting in Italy. The meeting provided a forum for scientists and clinicians working in cancer drug discovery and therapy to share their opinions and experiences. The text here offers readers an overview of diverse approaches, ranging from drug discovery to cellular therapy. Overall, the book addresses the key question of whether ultimately targeted therapy in cancer will be a myth or a reality.
World Bank Discussion Paper No. 347. Describes the elements of health reform in Sierra Leone as the West African nation attempts to overhaul its health system and focus it on the neediest populations. To highlight the role of key stakeholders, the study reviews the actions proposed and taken for reforming a package of health services, organizing the provision of those services, and financing the health sector. The paper also identifies factors critical for success and concludes with an assessment of future prospects for reform of this crucial sector.