How Technology Is Revolutionizing Advertising and the Way Companies Reach Consumers
Author: Mike Smith
Publisher: AMACOM Div American Mgmt Assn
Category: Business & Economics
Far from the catchy television spots and sleek magazine spreads are the comparatively modest ads that pop up on websites and in Internet searches. But don’t be fooled—online advertising is exploding. Growing at a compound annual rate near 20%, it is now the second-largest advertising channel in the United States. Part history, part guidebook, part prediction for the future, Targeted tells the story of the companies, individuals, and innovations driving this revolution. It takes readers behind the scenes—examining the growth of digital advertising, its enormous potential, and the technologies that are changing the game forever. Leading the way is real-time bidding, which offers advertisers unprecedented precision in targeting ads and measuring their effectiveness. From keyword micro-markets and ad serving systems to aggregated virtual audiences and new business models, Targeted is sweeping in scope and stripped of technical complexity. It is an essential resource for anyone interested in finding and connecting with customers in the vast and shifting Internet universe.
die völkerrechtliche Zulässigkeit der gezielten Tötung von Terroristen im Ausland
Author: Heiko F. Schmitz-Elvenich
Publisher: Peter Lang
Das Thema der -Gezielten Totung von Terroristen- ist aufgrund der jungsten Entwicklungen in der internationalen Terrorismusbekampfung von hochster Aktualitat. Insbesondere der von der US-Administration ausgerufene -Krieg gegen den Terror- und das israelische Vorgehen gegen palastinensische Extremisten haben eine intensive volkerrechtliche Diskussion in Gang gesetzt. Der Verfasser nimmt sich der vielschichtigen, eine ganze Reihe von Grundfragen des Volkerrechts beruhrenden Problematik an, um die politische Diskussion mit einer wissenschaftlich-volkerrechtlichen Analyse zu unterlegen. Er beleuchtet dabei im Schwerpunkt das UN-Chartarecht im Hinblick auf das Gewaltverbot und das volkerrechtliche Selbstverteidigungsrecht, widmet sich aber auch dem humanitaren Volkerrecht und dem internationalen Menschenrechtsschutz."
ZEROING IN Months after his wife had been brutally murdered, FBI profiler Alec Blade was on the desperate hunt to bring her murderer to justice. But after setting up residence in a sleepy Florida town, Alec made a startling discovery: The killer had a new target. Now, promising artist Katie Carroll was in danger and Alec's honor demanded he offer his protection. But long days—and nights—spent with Katie soon proved a distraction he couldn't afford. Could Alec uncover a deranged madman's true identity before it was too late?
Die Arbeit befasst sich mit der Untersuchung des Zusammenwirkens der Bereiche des humanitaren Volkerrechts und der Menschenrechte bezogen auf sogenannte "targeted killings," also gezielten Totungen von Mitgliedern nichtstaatlicher Kampfverbande durch einen Staat. Das "targeted killing" beruhrt einerseits das Recht auf Leben im Bereich der Menschenrechte und andererseits die Regeln zum Einsatz todlicher Gewalt im humanitaren Volkerrecht. Deshalb stellt es auch eine Schnittstelle der beiden Rechtsgebiete dar, deren Zusammenspiel noch immer nicht endgultig geklart ist. Hieran werden die Probleme der rechtlichen Einordnung von Massnahmen der internationalen Terrorismusbekampfung in den Rahmen des Volkerrechts aufgezeigt. Konnen gezielte Totungen von Mitgliedern internationaler terroristischer Organisationen durch einen Staat als legale Angriffsmittel nach dem Recht der bewaffneten Konflikte gelten? Oder sollten doch nur polizei- oder strafrechtliche Methoden und keine militarische Gewalt angewandt werden? Am Beispiel des "targeted killing" soll geklart werden, ob das bisherige System von Menschenrechten und humanitarem Volkerrecht dem internationalen Terrorismus und seiner Bekampfung Grenzen aufweisen kann, ohne die Effektivitat der Bekampfung gravierend zu behindern."
America has always portrayed itself as a country of immigrants, welcoming each year the millions seeking a new home or refuge in this land of plenty. Increasingly, instead of finding their dream, many encounter a nightmare—a country whose culture and legal system aggressively target and prosecute them. In Targeted, journalist Deepa Fernandes seamlessly weaves together history, political analysis, and first-person narratives of those caught in the grips of the increasingly Kafkaesque U.S. Homeland Security system. She documents how in post-9/11 America immigrants have come to be deemed a national security threat. Fernandes—herself an immigrant well-acquainted with U.S. immigration procedures—takes the reader on a harrowing journey inside the new American immigrant experience, a journey marked by militarized border zones, racist profiling, criminalization, detention and deportation. She argues that since 9/11, the Bush administration has been carrying out a series of systematic changes to decades-old immigration policy that constitute a roll back of immigrant rights and a boon for businesses who are helping to enforce the crackdown on immigrants, creating a growing "Immigration Industrial Complex." She also documents the bullet-to-ballot strategy of white supremacist elements that influence our new immigration legislation.
Terrorists are attacking airliners using an unknown weapon that one surviving passenger described as a "missile with wings." Deaths and injuries are in the hundreds. Rumors of extraterrestrial visitors have the public in a panic. People are afraid to set foot on an airliner. Experts wonder if TWA 800 might have been the first of the attacks. The airline business is in danger of folding unless the terrorists are caught. An ex air traffic controller turned lawyer, Kyle Matthews, a man the FAA once wanted to fire, is asked to investigate. But when Air Force One is attacked, and pieces of the weapon are found in the cockpit, Matthews realizes that no terrorist group would have the resources to fund such a weapon. He shifts the focus of his investigation to one of several government agency heads, and narrows his suspects down to one particular official who he feels is stonewalling him. Matthews sets a trap to force his suspect to confess. After boarding the flight, the suspect is led to believe that the flight is about to be shot down. The suspect confesses, but the flight is attacked anyway.
Emerging technologies in target identification, drug discovery, molecular markers, and imaging are rapidly changing the face of cancer. This book provides a foundation of knowledge in targeted cancer therapeutics. The treatment of cancer is increasingly being individualized, based on an understanding of underlying biologic mechanisms. Poised to change the landscape in oncology, this volume provides a state-of-the-art overview. It will be valuable to practicing and academic physicians, fellows, residents and students, as well as basic scientists, interested in the cancer field.
MARKED FOR MURDER When photos of Stephanie O'Brien are found in a serial killer's home, she must face the horrible truth that she's the next intended victim. She has nowhere to hide, nowhere to run—except to K-9 cop Rick Powell. As her self-appointed bodyguard, Rick will do anything to protect the innocent teacher—even keep his attraction at bay. He's known loss; he won't lose Stephanie. But the killer seems to anticipate their every move. And Rick fears he's never faced an opponent so cunning. One who won't stop till he has his victim right where he wants her…six feet under.
Author: Torgny Stigbrand,Jorgen Carlsson,Gregory P. Adams
Publisher: Springer Science & Business Media
The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.
For San Diego's elite FBI agents, risking their lives is standard procedure when it comes to capturing the city's most dangerous criminals-but falling in love is the greatest risk of all. RIPPED FROM THE HEADLINES . . . FBI Special Agent Marissa Panuska faces the most explosive case of her career when she impersonates a female terrorist to infiltrate an al-Qaeda cell. Her dark hair, olive complexion, and Arabic fluency make her the perfect imposter, but each passing hour raises the risk of discovery. Can she stop the dirty-bomb plot-alone-when the Feds don't even know the target? And should she trust the mysterious man who bursts into her life when her cover is blown? SO CLOSE TO REALITY . . . Former Navy SEAL Ameen Ali has a very personal reason for hating the terrorists and vowing to stop them. But when a beautiful woman joins the sleeper cell spreading death-to-America propaganda at his mosque, he doesn't want to believe she shares their evil goals. Can he convince her to join forces before it's too late?
Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.
Hidden in plain sight… Former Marine sniper and current NSA agent Jack Stone has a new face to go with his new identity. But he still has the same tortured memories—which include the woman he let get away years ago, when they were teenagers. Now his new assignment in Miami will put him so close to the woman he’s never been able to forget, he could reach out and touch her—if only she weren’t under suspicion. When Sophie Moreno uncovers evidence linking the medical supply company she works for with arms smuggling—and worse—she doesn’t know who to turn to. After a shocking betrayal, she realizes the only person she can trust is a mysterious new person in the company—a man with hauntingly familiar eyes. As Sophie questions her intense attraction to this man and Jack struggles not to blow his cover, the two of them must race against the clock to stop terrorists from killing scores of people—starting with them. FIRST IN A NEW SERIES!
This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.
Michael H. Weisman, Michael Weinblatt, James S Louie, and Ronald Van Vollenhoven offer their unique insights into choosing the correct pharmacological and non-pharmacological therapies for your patients. Chapters cover the full breadth of rheumatic diseases, rheumatoid arthritis, lupus, connective tissue diseases, osteoporosis, regional pain disorders, and fibromyalgia. The full-color design presents detailed clinical photographs and treatment algorithms for visual guidance and easy reference. Covers the treatment of pediatric patients as well as adults so that you can properly address the particular needs of any patient you see. Features the guidance and specific recommendations of experts from United States and Europe for a state-of-the-art approach to the variety of treatments currently in use. Displays the clinical manifestations of rheumatic diseases in full color, along with treatment algorithms for easy at-a-glance reference.
Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
Alexander F. Vakakis,Oleg V. Gendelman,Lawrence A. Bergman,D. Michael McFarland,Gaëtan Kerschen,Young Sup Lee
Author: Alexander F. Vakakis,Oleg V. Gendelman,Lawrence A. Bergman,D. Michael McFarland,Gaëtan Kerschen,Young Sup Lee
Publisher: Springer Science & Business Media
Category: Technology & Engineering
This monograph evolved over a period of nine years from a series of papers and presentations addressing the subject of passive vibration control of mechanical s- tems subjected to broadband, transient inputs. The unifying theme is Targeted - ergy Transfer – TET, which represents a new and unique approach to the passive control problem, in which a strongly nonlinear, fully passive, local attachment, the Nonlinear Energy Sink – NES, is employed to drastically alter the dynamics of the primary system to which it is attached. The intrinsic capacity of the properly - signed NES to promote rapid localization of externally applied (narrowband) - bration or (broadband) shock energy to itself, where it can be captured and dis- pated, provides a powerful strategy for vibration control and the opens the pos- bility for a wide range of applications of TET, such as, vibration and shock i- lation, passive energy harvesting, aeroelastic instability (?utter) suppression, se- mic mitigation, vortex shedding control, enhanced reliability designs (for ex- ple in power grids) and others. The monograph is intended to provide a thorough explanation of the analytical, computational and experimental methods needed to formulate and study TET in mechanical and structural systems. Several prac- cal engineering applications are examined in detail, and experimental veri?cation and validation of the theoretical predictions are provided as well. The authors also suggest a number of possible future applications where application of TET seems promising. The authors are indebted to a number of sponsoring agencies.
This book does nothing less than lay out the state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities. The sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to derive more efficient cancer drugs?
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.