Regenesis

How Synthetic Biology Will Reinvent Nature and Ourselves

Author: George M. Church,Ed Regis

Publisher: Basic Books

ISBN: 0465038654

Category: Science

Page: 304

View: 8314

“Bold and provocative… Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species.”—New Scientist In Regenesis, Harvard biologist George Church and science writer Ed Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

Regenesis

How Synthetic Biology Will Reinvent Nature and Ourselves

Author: George M. Church,Ed Regis

Publisher: Hachette UK

ISBN: 0465038654

Category: Science

Page: 304

View: 1919

“Bold and provocative… Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species.”—New Scientist In Regenesis, Harvard biologist George Church and science writer Ed Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

Synthetic Biology and Morality

Artificial Life and the Bounds of Nature

Author: Gregory E. Kaebnick,Thomas H. Murray

Publisher: MIT Press

ISBN: 0262519593

Category: Philosophy

Page: 214

View: 1356

A range of views on the morality of synthetic biology and its place in public policy and political discourse.

Life at the Speed of Light

From the Double Helix to the Dawn of Digital Life

Author: J. Craig Venter

Publisher: Penguin

ISBN: 0143125907

Category: Science

Page: 224

View: 4381

The author of A Life Decoded explains how his team's achievement with sequencing the human genome has launched an important age of biological research, revealing a growing potential for enabling humans to adapt and evolve for long-term survival and environmental improvement.

What is Life?

Investigating the Nature of Life in the Age of Synthetic Biology

Author: Edward Regis

Publisher: Oxford University Press, USA

ISBN: 0195383419

Category: Science

Page: 198

View: 9347

Erwin Schrödinger's 1944 classic What Is Life? is a small book that occupies a large place among the great written works of the twentieth century. It is said that it helped launch the modern revolution in biology and genetics, and inspired a generation of scientists, including Watson and Crick, to explore the riddle of life itself. Now, more than sixty years later, science writer Ed Regis offers an intriguing look at where this quest stands today. Regis ranges widely here, illuminating many diverse efforts to solve one of science's great mysteries. He examines the genesis of Schrödinger's great book--which first debuted as three public lectures in Dublin--and details the fantastic reception his ideas received, both in Europe and America. Regis also introduces us to the work of a remarkable group of scientists who are attempting literally to create life from scratch, starting with molecular components that they hope to assemble into the world's first synthetic living cell. The book also examines how scientists have unlocked the "three secrets of life," describes the key role played by ATP ("the ultimate driving force of all life"), and outlines the many attempts to explain how life first arose on earth, a puzzle that has given birth to a wide range of theories (which Francis Crick dismissed as "too much speculation running after too few facts"), from the primordial sandwich theory, to the theory that life arose in clay, in deep-sea vents, or in oily bubbles at the seashore, right up to Freeman Dyson's "theory of double origins." Written in a lively and accessible style, and bringing together a wide range of cutting-edge research, What is Life? makes an illuminating contribution to this ancient and ever-fascinating debate.

BioBuilder

Synthetic Biology in the Lab

Author: Natalie Kuldell PhD.,Rachel Bernstein,Karen Ingram,Kathryn M Hart

Publisher: "O'Reilly Media, Inc."

ISBN: 1491907533

Category: Science

Page: 238

View: 6811

Today’s synthetic biologists are in the early stages of engineering living cells to help treat diseases, sense toxic compounds in the environment, and produce valuable drugs. With this manual, you can be part of it. Based on the BioBuilder curriculum, this valuable book provides open-access, modular, hands-on lessons in synthetic biology for secondary and post-secondary classrooms and laboratories. It also serves as an introduction to the field for science and engineering enthusiasts. Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges. Learn the fundamentals of biodesign and DNA engineering Explore important ethical issues raised by examples of synthetic biology Investigate the BioBuilder labs that probe the design-build-test cycle Test synthetic living systems designed and built by engineers Measure several variants of an enzyme-generating genetic circuit Model "bacterial photography" that changes a strain’s light sensitivity Build living systems to produce purple or green pigment Optimize baker’s yeast to produce ?-carotene

Synthetic

How Life Got Made

Author: Sophia Roosth

Publisher: University of Chicago Press

ISBN: 022644046X

Category: Science

Page: 256

View: 2059

In the final years of the twentieth century, emigres from mechanical and electrical engineering and computer science resolved that if the aim of biology was to understand life, then making life would yield better theories than experimentation. Sophia Roosth, a cultural anthropologist, takes us into the world of these self-named synthetic biologists who, she shows, advocate not experiment but manufacture, not reduction but construction, not analysis but synthesis. Roosth reveals how synthetic biologists make new living things in order to understand better how life works. What we see through her careful questioning is that the biological features, theories, and limits they fasten upon are determined circularly by their own experimental tactics. This is a story of broad interest, because the active, interested making of the synthetic biologists is endemic to the sciences of our time."

Rise of the Necrofauna

The Science, Ethics, and Risks of De-Extinction

Author: Britt Wray

Publisher: Greystone Books Ltd

ISBN: 1771641630

Category: Science

Page: 304

View: 9426

Jurassic Park meets The Sixth Extinction in Rise of the Necrofauna, a provocative look at de-extinction from acclaimed documentarist and science writer Britt Wray. A captivating whirlwind tour through the birth and early life of the scientific idea known as “de-extinction.”—Beth Shapiro, author of How to Clone a Mammoth: The Science of De-Extinction What happens when you try to recreate a woolly mammoth—fascinating science, or conservation catastrophe? In Rise of the Necrofauna, Wray takes us deep into the minds and labs of some of the world's most progressive thinkers to find out. She introduces us to renowned futurists like Stewart Brand and scientists like George Church, who are harnessing the powers of CRISPR gene editing in the hopes of "reviving" extinct passenger pigeons, woolly mammoths, and heath hens. She speaks with Nikita Zimov, who together with his eclectic father Sergey, is creating Siberia's Pleistocene Park—a daring attempt to rebuild the mammoth's ancient ecosystem in order to save earth from climate disaster. Through interviews with these and other thought leaders, Wray reveals the many incredible opportunities for research and conservation made possible by this emerging new field. But we also hear from more cautionary voices, like those of researcher and award-winning author Beth Shapiro (How to Clone a Woolly Mammoth) and environmental philosopher Thomas van Dooren. Writing with passion and perspective, Wray delves into the larger questions that come with this incredible new science, reminding us that de-extinction could bring just as many dangers as it does possibilities. What happens, for example, when we bring an "unextinct" creature back into the wild? How can we care for these strange animals and ensure their comfort and safety—not to mention our own? And what does de-extinction mean for those species that are currently endangered? Is it really ethical to bring back an extinct passenger pigeon, for example, when countless other birds today will face the same fate? By unpacking the many biological, technological, ethical, environmental, and legal questions raised by this fascinating new field, Wray offers a captivating look at the best and worst of resurrection science. Published in partnership with the David Suzuki Institute.

Biopunk

Solving Biotech's Biggest Problems in Kitchens and Garages

Author: Marcus Wohlsen

Publisher: N.A

ISBN: 1617230073

Category: Science

Page: 250

View: 776

Examines the growing community of scientists working outside of the traditional corporate and academic environments to make biotechnology tools broadly available in order to fuel an explosion of innovation in genetic modification.

Synthetic Biology

A Lab Manual

Author: Josefine Liljeruhm,Erik Gullberg,Anthony C Forster

Publisher: World Scientific

ISBN: 9814579564

Category: Science

Page: 204

View: 7207

Synthetic Biology: A Lab Manual is the first manual for laboratory work in the new and rapidly expanding field of synthetic biology. Aimed at non-specialists, it details protocols central to synthetic biology in both education and research. In addition, it provides all the information that teachers and students from high schools and tertiary institutions need for a colorful lab course in bacterial synthetic biology using chromoproteins and designer antisense RNAs. As a bonus, practical material is provided for students of the annual international Genetically Engineered Machine (iGEM) competition. The manual is based upon a highly successful course at Sweden's Uppsala University and is coauthored by one of the pioneers of synthetic biology and two bioengineering postgraduate students. An inspiring foreword is written by another pioneer in the field, Harvard's George Church: “Synthetic biology is to early recombinant DNA as a genome is to a gene. Is there anything that SynBio will not impact? There was no doubt that the field of SynBio needed ‘A Lab Manual’ such as the one that you now hold in your hands.” Read about the interview with the authors! Contents:Introduction:What is Synthetic Biology, Exactly?The iGEM OutbreakA Synthetic Biology Lab ManualGenes, Chromoproteins and Antisense RNAs:E. coli DNA: Chromosomes, Plasmids and Copy NumberCoupling of Transcription and Translation in BacteriaPromoter and Terminator for TranscriptionRibosome Binding Site (RBS)Codon BiasChromoproteinsSmall Regulatory RNAs (sRNAs)Lab Rooms and Equipment:The Physical Lab SpacesEquipmentSafety is Priority #1:FiresChemicalsBiological Safety and DisposalDangerous EquipmentLab Course Projects:Time and ResourcesProject Overview and Learning ObjectivesThe Lab NotebookLab Section 1. Preparation of Chemical Solutions and Agar PlatesLab Section 2. Coloring Bacteria by Adding a Promoter to a Chromoprotein GeneLab Section 3: Rational Engineering of Chromoprotein Expression LevelLab Section 4. Other ExperimentsThe “Dreaded” ExamProtocols:IntroductionProtocol 1. Preparation of Solutions and Agar PlatesProtocol 2. Overnight Cultures with Antibiotics, and Glycerol StocksProtocol 3. BioBrick™ 3A Assembly and Gel AnalysisProtocol 4. Agarose Gel ElectrophoresisProtocol 5. Preparation of Competent E. coli Cells Using CaCl2Protocol 6. Transformation of CaCl2-Competent E. coli CellsProtocol 7. Bacterial Re-Streaking TechniquesProtocol 8. Lysis of E. coli Cells with LysozymeProtocol 9. Polymerase Chain Reaction (PCR)Protocol 10. Inverse PCR MutagenesisProtocol 11. Colony PCRProtocol 12. Gibson AssemblyAdvanced Methods:Flow Cytometry and Cell SortingRecombination in Plasmids and the ChromosomeElectrocompetent CellsThe International Genetically Engineered Machine (iGEM) Competition:How to Start an iGEM TeamUppsala iGEM 2011 — Show Color with ColorUppsala iGEM 2012 — Resistance is FutileUppsala iGEM 2013 — Lactonutritious — It's DeliciousAppendices Readership: Students and researchers in biotechnology, cell/molecular biology and genetics. Keywords:Synthetic Biology;Genetic Engineering;DNA Cloning;Polymerase Chain Reaction;Molecular Biology;Laboratory;Biobrick;Chromoprotein;Manual;CourseReviews: It provides an introductory workflow for common techniques and would be of definite use to educators wanting to bring synthetic biology into the classroom or for motivated undergraduate students with the desire to start thir own iGEM team.” Synthetic Biology See Full Review

Evolving Ourselves

Redesigning the Future of Humanity--One Gene at a Time

Author: Juan Enriquez,Steve Gullans

Publisher: Penguin

ISBN: 0698174984

Category: Science

Page: 384

View: 740

“We are the primary drivers of change. We will directly and indirectly determine what lives, what dies, where, and when. We are in a different phase of evolution; the future of life is now in our hands.” Why are rates of conditions like autism, asthma, obesity, and allergies exploding at an unprecedented pace? Why are humans living longer, getting smarter, and having far fewer kids? How might your lifestyle affect your unborn children and grandchildren? How will gene-editing technologies like CRISPR steer the course of human evolution? If Darwin were alive today, how would he explain this new world? Could our progeny eventually become a different species—or several? In Evolving Ourselves, futurist Juan Enriquez and scientist Steve Gullans conduct a sweeping tour of how humans are changing the course of evolution—sometimes intentionally, sometimes not. For example: • Globally, rates of obesity in humans nearly doubled between 1980 and 2014. What’s more, there’s evidence that other species, from pasture-fed horses to lab animals to house cats, are also getting fatter. • As reported by U.S. government agencies, the rate of autism rose by 131 percent from 2001 to 2010, an increase that cannot be attributed simply to increases in diagnosis rates. • Three hundred years ago, almost no one with a serious nut allergy lived long enough to reproduce. Today, despite an environment in which food allergies have increased by 50 percent in just over a decade, 17 million Americans who suffer from food allergies survive, thrive, and pass their genes and behaviors on to the next generation. • In the pre-Twinkie era, early humans had quite healthy mouths. As we began cooking, bathing, and using antibiotics, the bacteria in our bodies changed dramatically and became far less diverse. Today the consequences are evident not only in our teeth but throughout our bodies and minds. Though these harbingers of change are deeply unsettling, the authors argue that we are also in an epoch of tremendous opportunity. New advances in biotechnology help us mitigate the cruel forces of natural selection, from saving prematurely born babies to gene therapies for sickle cell anemia and other conditions. As technology like CRISPR enables us to take control of our genes, we will be able to alter our own species and many others—a good thing, given that our eventual survival will require space travel and colonization, enabled by a fundamental redesign of our bodies. Future humans could become great caretakers of the planet, as well as a more diverse, more resilient, gentler, and more intelligent species—but only if we make the right choices now. Intelligent, provocative, and optimistic, Evolving Ourselves is the ultimate guide to the next phase of life on Earth. From the Hardcover edition.

The Synthetic Age

Outdesigning Evolution, Resurrecting Species, and Reengineering Our World

Author: Christopher J. Preston

Publisher: Mit Press

ISBN: 9780262037617

Category: Nature

Page: 224

View: 2875

Imagining a future in which humans fundamentally reshape the natural world using nanotechnology, synthetic biology, de-extinction, and climate engineering. We have all heard that there are no longer any places left on Earth untouched by humans. The significance of this goes beyond statistics documenting melting glaciers and shrinking species counts. It signals a new geological epoch. In The Synthetic Age, Christopher Preston argues that what is most startling about this coming epoch is not only how much impact humans have had but, more important, how much deliberate shaping they will start to do. Emerging technologies promise to give us the power to take over some of Nature's most basic operations. It is not just that we are exiting the Holocene and entering the Anthropocene; it is that we are leaving behind the time in which planetary change is just the unintended consequence of unbridled industrialism. A world designed by engineers and technicians means the birth of the planet's first Synthetic Age. Preston describes a range of technologies that will reconfigure Earth's very metabolism: nanotechnologies that can restructure natural forms of matter; "molecular manufacturing" that offers unlimited repurposing; synthetic biology's potential to build, not just read, a genome; "biological mini-machines" that can outdesign evolution; the relocation and resurrection of species; and climate engineering attempts to manage solar radiation by synthesizing a volcanic haze, cool surface temperatures by increasing the brightness of clouds, and remove carbon from the atmosphere with artificial trees that capture carbon from the breeze. What does it mean when humans shift from being caretakers of the Earth to being shapers of it? And in whom should we trust to decide the contours of our synthetic future? These questions are too important to be left to the engineers.

The Ones

Author: Daniel Sweren-Becker

Publisher: Imprint

ISBN: 125008315X

Category: Young Adult Fiction

Page: 320

View: 3739

We are not all created equal. Seventeen-year-old Cody and her boyfriend, James, were two of the lucky ones randomly selected before birth to receive genetic engineering. Known as the Ones, this one percent of the population is healthy, beautiful, and talented...and to some that's not fair. Mounting fear and jealousy of the Ones’ success leads to the creation of the Equality Movement, which quickly gains enough political traction to demote Cody, James, and others like them to second-class citizens. Cody knows even before the brick smashes through her window that it's going to be bad. As their school, the American government, and even family and friends turn against them, Cody begins to believe they have no other choice but to protect their own. She draws closer to a group of radical Ones led by the passionate and fevered Kai, and James begins to question just how far she is willing to go for the cause... Themes of justice, discrimination and terrorism mix with actual science to create a frightening version of our near future in Daniel Sweren-Becker's pulse-pounding thriller. An Imprint Book

Synthetic Biology Handbook

Author: Darren N. Nesbeth

Publisher: CRC Press

ISBN: 1466568488

Category: Medical

Page: 318

View: 3092

The Synthetic Biology Handbook explains the major goals of the field of synthetic biology and presents the technical details of the latest advances made in achieving those goals. Offering a comprehensive overview of the current areas of focus in synthetic biology, this handbook: Explores the standardisation of classic molecular bioscience approaches Addresses the societal context and potential impacts of synthetic biology Discusses the use of legacy systems as tools for new product development Examines the design and construction of de novo cells and genetic codes Describes computational methods for designing genes and gene networks Thus, the Synthetic Biology Handbook provides an accurate sense of the scope of synthetic biology today. The handbook also affords readers with an opportunity to scrutinize the underlying science and decide for themselves what aspects of synthetic biology are most valuable to their research and practice.

Synthetic Biology

Safety, Security, and Promise

Author: Gigi Gronvall

Publisher: Createspace Independent Publishing Platform

ISBN: 9781539336839

Category:

Page: 198

View: 9271

Synthetic biology aims to make biology easier to engineer and to program. Thanks to advances in computing power, the ability to make long tracts of DNA, new tools like CRISPR that can be used to edit genomes, and the enthusiasm of young scientists and even amateurs who want to enter the field, synthetic biology is poised to change the future of medicine, agriculture, and manufacturing. Yet, while this new field promises vast opportunities and benefits, there are also risks. There are biosecurity risks that these technologies will be deliberately used for harm; safety risks to people and the environment; ethical and social considerations for how to apply these technologies; and there are risks to the competitiveness of nations that do not invest in these technologies that are likely to spur economic growth. This volume is dedicated to a discussion of what can be done to minimize risks and maximize the benefits of synthetic biology. Praise for Synthetic Biology: Safety, Security, and Promise "There can be no doubt that advances in the life sciences, including new insights and tools provided by synthetic biology, place us in a position to create exciting and novel products and approaches for patients in need. Gigi Gronvall describes that promise but also lays forth critical policy concerns that need to be addressed so that we don't risk safety, security, or the competitiveness of US science." - Margaret Hamburg, MD, Former FDA Commissioner and Foreign Secretary, National Academy of Medicine "Synthetic biology gives us tools that can help tackle global problems that affect humanity-but for that to happen, the risks of bioterror or bio-error need to be dealt with and managed, as well. Gronvall clearly describes the policy challenges that must be addressed and concludes with steps to enhance US leadership and competitiveness in the global bio-economy." - J. Craig Venter, PhD, founder, chairman, and CEO of the J. Craig Venter Institute and co-founder, executive chairman and co-chief scientist of Synthetic Genomics, Inc. "For those of us working in the lab, it is important to embrace conversations with those who aren't - including strategies for biological security, to create new synthetic biology products - with respect for facts about GMO risk/benefit balances, creating a culture of safe lab practices and norms worldwide. Gigi Gronvall dissects such issues at stake in synthetic biology and presents a pragmatic and scientifically responsive path forward for anyone in a position to influence, regulate, decide upon, or benefit from the science to follow." - George Church, PhD, Professor of Genetics Harvard Medical School and Director of PersonalGenomes.org "Synthetic biology presents some of the greatest challenges and opportunities of the 21st Century. Gigi Gronvall navigates a path to follow, to make sure risks are addressed and opportunities are not squandered. It should be read by all concerned about national security." - The Honorable Andrew Weber, head of global partnerships for Metabiota and former Assistant Secretary of Defense for Nuclear, Chemical, and Biological Defense Programs

The Phantom of the Earth

Author: Raeden Zen

Publisher: Lulu Press, Inc

ISBN: 136584238X

Category: Fiction

Page: N.A

View: 8694

Herbert's DUNE meets Banks' THE PLAYER OF GAMES in THE PHANTOM OF THE EARTH, a spellbinding science fiction epic set deep underground after the fall of civilization on Earth's surface. Here are the five thought-provoking postapocalyptic stories that lovers of science fiction can't stop talking about, gathered together in one volume for the first time. At the center of the conflict lie the Selendias of Piscator, founders of the resistance with an uncanny connection to the zeropoint field; and the Barão Strike Team, three researchers tasked with finding a cure to the Reassortment Strain, the plague that nearly wiped humanity from the Earth. Traveling from the uninhabitable but pristine surface to the habitable but inhospitable underground, this is a story about dedication to dreams, battle for survival, discovery and connection, song and celebration, undoing past misdeeds, and sacrifice for the greater good.

Evolving Ourselves

Redesigning the Future of Humanity - One Gene at a Time

Author: Juan Enriquez,Steve Gullans

Publisher: Penguin

ISBN: 0143108344

Category: Science

Page: 384

View: 5370

"Futurist Juan Enriquez and scientist Steve Gullans conduct a sweeping tour of how humans are changing the course of evolution for all species--sometimes intentionally, sometimes not. For example: What if life forms are limited only by the bounds of our imagination? Are designer babies and pets, de-extinction, even entirely newspecies fair game?; As humans, animals, and plants become ever more resistant to disease and aging, what will become the leading causes of death?; Man-machine interfaces may allow humans to live much longer. What will happen when we transfer parts of our 'selves' into clones, into stored cells and machines? Though these harbingers of change are deeply unsettling, the authors argue we are also in an epoch of tremendous opportunity. Future humans, perhaps a more diverse, resilient, gentler, and intelligent species, may become better caretakers of the planet--but only if we make the right choices now."--Provided by publisher.

Synthetic Aesthetics

Investigating Synthetic Biology's Designs on Nature

Author: Alexandra Daisy Ginsberg,Jane Calvert,Pablo Schyfter,Alistair Elfick,Drew Endy

Publisher: MIT Press

ISBN: 026201999X

Category: Medical

Page: 376

View: 4272

As synthetic biology transforms living matter into a medium for making, what is the role of design and its associated values?

Creation

How Science Is Reinventing Life Itself

Author: Adam Rutherford

Publisher: Penguin

ISBN: 1617230111

Category: Science

Page: 278

View: 3735

"How scientists are closer than ever to not only uncovering the mystery of how life was created, but to replicating that moment Within the first billion years after this planet formed, a spark of life spontaneously ignited, turning inanimate chemicals into what we now would recognize as a living thing: a cell. Four billion years later, science has catalogued more than a million species. Science writer Adam Rutherford shows how unprecedented advances in our understanding of life have equipped us with the ability to create entirely new life-forms: goats that produce spider silk in their milk, bacteria that excrete diesel, genetic codes that identify and destroy cancer cells. This new synthetic biology is poised to offer radical new solutions to the crises of food shortage, pandemic disease, and climate change. By charting the history of our evolution, questioning what life really is, and identifying the milestones in our understanding of biological processes, Rutherford shows how this frontier of science will kickstart an industrial revolution that will dominate the rest of this century"--Provided by publisher.