This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six times by the authors at Texas A&M University. After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues are covered. The imaging modalities include ballistic imaging, quasi-ballistic imaging (optical coherence tomography), diffusion imaging, and ultrasound-aided hybrid imaging. The basic physics and engineering of each imaging technique are emphasized. A solutions manual is available for instructors; to obtain a copy please email the editorial department at [email protected]
Author: David A. Boas,Constantinos Pitris,Nimmi Ramanujam
Publisher: CRC Press
Category: Technology & Engineering
Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamentals of each subject, ensuring accessibility to a wide multidisciplinary readership. It also offers a view of the state of the art and discusses advantages and disadvantages of various techniques. Organized into six sections, this handbook: Contains introductory material on optics and the optical properties of tissue Describes the various forms of spectroscopy and its applications in medicine and biology, including methods that exploit intrinsic absorption and scattering contrast; dynamic contrast; and fluorescence and Raman contrast mechanisms Provides extensive coverage of tomography from the microscopic (optical coherence tomography) to the macroscopic (diffuse optical tomography) to photoacoustic tomography Discusses cutting-edge translations to biomedical applications in both basic sciences and clinical studies Details molecular imaging and molecular probe development Highlights the use of light in disease and injury treatment The breadth and depth of multidisciplinary knowledge in biomedical optics has been expanding continuously and exponentially, thus underscoring the lack of a single source to serve as a reference and teaching tool for scientists in related fields. Handbook of Biomedical Optics addresses this need, offering the most complete up-to-date overview of the field for researchers and students alike.
Prof. Boudoux's book covers a comprehensive range of topics in biomedical optics and biophotonics. The organization of the material is well thought out, starting off with a toolbox of essential concepts that are general and yet detailed enough for a broad range of student backgrounds. The heart of the book covers the essential topics of tissue optics, as well as optical imaging system design concepts. With a well-balanced combination of engineering and physics, this text is an asset for students, and will be a valued long-term reference.
A Survey of Practical Models, Algorithms, and Numerical Methods
Author: Russell Schwartz
Publisher: MIT Press
There are many excellent computational biology resources now available for learning about methods that have been developed to address specific biological systems, but comparatively little attention has been paid to training aspiring computational biologists to handle new and unanticipated problems. This text is intended to fill that gap by teaching students how to reason about developing formal mathematical models of biological systems that are amenable to computational analysis. It collects in one place a selection of broadly useful models, algorithms, and theoretical analysis tools normally found scattered among many other disciplines. It thereby gives the aspiring student a bag of tricks that will serve him or her well in modeling problems drawn from numerous subfields of biology. These techniques are taught from the perspective of what the practitioner needs to know to use them effectively, supplemented with references for further reading on more advanced use of each method covered. The text, which grew out of a class taught at Carnegie Mellon University, covers models for optimization, simulation and sampling, and parameter tuning. These topics provide a general framework for learning how to formulate mathematical models of biological systems, what techniques are available to work with these models, and how to fit the models to particular systems. Their application is illustrated by many examples drawn from a variety of biological disciplines and several extended case studies that show how the methods described have been applied to real problems in biology.
A Systems Based Overview Using Engineering Standards
Author: Gail D. Baura
Publisher: Academic Press
The goal of this textbook is to provide undergraduate engineering students with an introduction to commonly manufactured medical devices. It is the first textbook that discusses both electrical and mechanical medical devices. The first 20 chapters are medical device technology chapters; the remaining 8 chapters are medical device laboratory experiment chapters. Each medical device chapter begins with an exposition of appropriate physiology, mathematical modeling or biocompatibility issues, and clinical need. A device system description and system diagram provide details on technology function and administration of diagnosis and/or therapy. The systems approach enables students to quickly identify the relationships between devices. Device key features are based on five applicable consensus standard requirements from organizations such as ISO and the Association for the Advancement of Medical Instrumentation (AAMI). Key Features: The medical devices discussed are Nobel Prize or Lasker Clinical Prize winners, vital signs devices, and devices in high industry growth areas Three significant Food and Drug Administration (FDA) recall case studies which have impacted FDA medical device regulation are included in appropriate device chapters Exercises at the end of each chapter include traditional homework problems, analysis exercises, and four questions from assigned primary literature Eight laboratory experiments are detailed that provide hands-on reinforcement of device concepts
The first MATLAB-based numerical methods textbook for bioengineers that uniquely integrates modelling concepts with statistical analysis, while maintaining a focus on enabling the user to report the error or uncertainty in their result. Between traditional numerical method topics of linear modelling concepts, nonlinear root finding, and numerical integration, chapters on hypothesis testing, data regression and probability are interweaved. A unique feature of the book is the inclusion of examples from clinical trials and bioinformatics, which are not found in other numerical methods textbooks for engineers. With a wealth of biomedical engineering examples, case studies on topical biomedical research, and the inclusion of end of chapter problems, this is a perfect core text for a one-semester undergraduate course.
The second edition of this popular introductory undergraduate textbook uses examples, applications, and profiles of biomedical engineers to show students the relevance of the theory and how it can be used to solve real problems in human medicine. The essential molecular biology, cellular biology, and human physiology background is included for students to understand the context in which biomedical engineers work. Updates throughout highlight important advances made over recent years, including iPS cells, microRNA, nanomedicine, imaging technology, biosensors, and drug delivery systems, giving students a modern description of the various subfields of biomedical engineering. Over two hundred quantitative and qualitative exercises, many new to this edition, help consolidate learning, whilst a solutions manual, password-protected for instructors, is available online. Finally, students can enjoy an expanded set of leader profiles in biomedical engineering within the book, showcasing the broad range of career paths open to students who make biomedical engineering their calling.
This book is ideal for teaching students in engineering or physics the skills necessary to analyze motions of complex mechanical systems such as spacecraft, robotic manipulators, and articulated scientific instruments. Kane's method, which emerged recently, reduces the labor needed to derive equations of motion and leads to equations that are simpler and more readily solved by computer, in comparison to earlier, classical approaches. Moreover, the method is highly systematic and thus easy to teach. This book is a revision of Dynamics: Theory and Applications (1985), by T. R. Kane and D. A. Levinson, and presents the method for forming equations of motion by constructing generalized active forces and generalized inertia forces. Important additional topics include approaches for dealing with finite rotation, an updated treatment of constraint forces and constraint torques, an extension of Kane's method to deal with a broader class of nonholonomic constraint equations, and other recent advances.
Covering the basics of X-rays, CT, PET, nuclear medicine, ultrasound, and MRI, this textbook provides senior undergraduate and beginning graduate students with a broad introduction to medical imaging. Over 130 end-of-chapter exercises are included, in addition to solved example problems, which enable students to master the theory as well as providing them with the tools needed to solve more difficult problems. The basic theory, instrumentation and state-of-the-art techniques and applications are covered, bringing students immediately up-to-date with recent developments, such as combined computed tomography/positron emission tomography, multi-slice CT, four-dimensional ultrasound, and parallel imaging MR technology. Clinical examples provide practical applications of physics and engineering knowledge to medicine. Finally, helpful references to specialised texts, recent review articles, and relevant scientific journals are provided at the end of each chapter, making this an ideal textbook for a one-semester course in medical imaging.
Introduction to Optical Microscopy provides a rigorous and comprehensive overview of the fundamentals of optical microscopy. Starting from basic principles in Fourier optics, partial coherence, 3D imaging theory, and the physics of scattering and fluorescence, Introduction to Optical Microscopy explores a broad range of microscopy techniques. These include classical techniques such as phase contrast, confocal microscopy, etc., and progress to more modern techniques such as holographic microscopy, optical coherence tomography, two-photon microscopy, coherent anti-Stokes Raman scattering microscopy, etc.. The final chapters present a survey of new directions, including structured illumination and superresolution. Introduction to Optical Microscopy is designed to provide a solid theoretical foundation for graduate students or researchers who want to enter the field. While valuable as a reference, it can also serve as a textbook, as it includes a corresponding website that provides problem sets and an instructor's solution manual.
Understanding LED Illumination elucidates the science of lighting for light emitting diodes. It presents concepts, theory, simulations, and new design techniques that shine the spotlight on illumination, energy efficiency, and reducing electrical power consumption. The text provides an introduction to the fundamentals of LED lamp design, and highlights the principles of large-space and 3D object illumination for developing competitive LED lamps. The first part of the book discusses lamp output metrics and characterization methods, while the second part of the book explores certain retail and prototype lamp comparisons with theory, simulations and experiments It details the light propagation and distribution characteristics of LED light sources for general illumination applications, and presents design and simulation requirements for LED lamps suited for real-world applications. It also addresses light generation, efficiency, theoretical limits, efficiency limiting factors, and LED lamp design elements. Emphasizes the lighting aspects for LED lamps: quality and improvement Describes the basics of junction diode and the intricacies of compound semiconductor optoelectronic properties including the thermal, electrical, optical, and mechanical aspects Explains the challenges of LED lighting in scientific and mathematical terms Includes case studies from Osram Optosemiconductors, Sylvania, and Phillips, GE, and others The book characterizes several LED replacement lamps for household and commercial lighting and discusses a novel design for improving tubular LED replacements. It takes the mysteries out of solid-state lighting for lighting designers, and helps LED scientists and engineers effectively design their products to provide high-quality illumination.
Third International Joint Conference, BIOSTEC 2010, Valencia, Spain, January 20-23, 2010, Revised Selected Papers
Author: Ana Fred,Joaquim Filipe,Hugo Gamboa
Publisher: Springer Science & Business Media
This book constitutes the thoroughly refereed post-conference proceedings of the Third International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2010, held in Valencia, Spain, in January 2010. The 30 revised full papers presented together with 1 invited lecture were carefully reviewed and selected from a total of 410 submissions in two rounds of reviewing and improvement. The papers cover a wide range of topics and are organized in four general topical sections on healthinf, biodevices, biosignals, and bioinformatics.
The book is designed for end users in the field of digital imaging, who wish to update their skills and understanding with the latest techniques in image analysis. The book emphasizes the conceptual framework of image analysis and the effective use of image processing tools. It uses applications in a variety of fields to demonstrate and consolidate both specific and general concepts, and to build intuition, insight and understanding. Although the chapters are essentially self-contained they reference other chapters to form an integrated whole. Each chapter employs a pedagogical approach to ensure conceptual learning before introducing specific techniques and “tricks of the trade”. The book concentrates on a number of current research applications, and will present a detailed approach to each while emphasizing the applicability of techniques to other problems. The field of topics is wide, ranging from compressive (non-uniform) sampling in MRI, through automated retinal vessel analysis to 3-D ultrasound imaging and more. The book is amply illustrated with figures and applicable medical images. The reader will learn the techniques which experts in the field are currently employing and testing to solve particular research problems, and how they may be applied to other problems.
This book introduces senior-level and postgraduate students to the principles and applications of biophotonics. It also serves as a valuable reference resource or as a short-course textbook for practicing physicians, clinicians, biomedical researchers, healthcare professionals, and biomedical engineers and technicians dealing with the design, development, and application of photonics components and instrumentation to biophotonics issues. The topics include the fundamentals of optics and photonics, the optical properties of biological tissues, light-tissue interactions, microscopy for visualizing tissue components, spectroscopy for optically analyzing the properties of tissue, and optical biomedical imaging. It also describes tools and techniques such as laser and LED optical sources, photodetectors, optical fibers, bioluminescent probes for labeling cells, optical-based biosensors, surface plasmon resonance, and lab-on-a-chip technologies. Among the applications are optical coherence tomography (OCT), optical imaging modalities, photodynamic therapy (PDT), photobiostimulation or low-level light therapy (LLLT), diverse microscopic and spectroscopic techniques, tissue characterization, laser tissue ablation, optical trapping, and optogenetics. Worked examples further explain the material and how it can be applied to practical designs, and the homework problems help test readers’ understanding of the text.
Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course.