Thoroughly updated, incorporating around 25 % new material, Sewald/Jakubke remains the only modern and scientifically up-to-date advanced textbook on peptide biochemistry, distilling the knowledge of hundreds of publications into a highly readable synopsis of this diverse field. The authors explain the broad fundamentals of peptide synthesis and structure, systematically addressing important families of biologically active peptides, and adopting an interdisciplinary approach that covers application areas in biotechnology, pharmaceutical science, and biomedicine. One major focus is on such "hot" research topics as pseudopeptides, peptidomimetics, and combinatorial synthesis. This new edition also features study questions for each learning unit, for easier self-study and classroom teaching.
This mini-encyclopedia contains more than 1,500 alphabetical entries from the entire field of peptide science in one handy volume, as well as the technical terms, acronyms and concepts used in peptide chemistry. It also features the complete sequence of more than 800 peptides, numerous illustrations and numerous cross-references. Areas covered include: - biological peptides and small proteins - peptide hormones - pharmaceutical peptides - peptide antibiotics - peptide inhibitors - peptide reagents - peptide tags - structural classes - synthesis and purification - analytical methods - proteomics and peptidomics. Condensed yet accessible, only essential information is displayed, extensively linked via references to the recent scientific literature for further study.
This unique reference book contains 372 articles selected from 762 plenary lectures, workshops and poster presentations made during the Thirteenth American Peptide Symposium held in Edmonton, Alberta, Canada. The book opens with Nobel Laureate Dr. Bruce Merrifield's `Remarks on Peptide Chemistry' which focus on past scientists and their contributions of peptide chemistry in all aspects of biology, and Dr. Victor Hruby's Pierce Award Lecture on designing peptides, pseudopeptides and peptidomimetics to understand the relationship between structure and biology activity. The contributions are grouped into 14 sections: Synthetic and Analytical Methods Peptide Mimetics Glycopeptides/Lipopeptides Peptide Hormones/Neuropeptides Peptide Inhibitors/Peptide-Receptor Interactions Peptide Vaccines and Immunology Conformational Analysis Peptide Pharmaceuticals/Diagnostics and Peptide Delivery Computational Biochemistry Peptide Macromolecular Interactions Peptide Libraries De novo Design of Peptides and Proteins; and three Workshops: Approaches and Advances in Peptide Synthesis, Purification and Analysis An Introduction to NMR Spectroscopy of Peptides An Introduction to Energy Minimization, Molecular Dynamics, Molecular Modelling and Conformational Analysis of Peptides. This 1200 page compendium of current research from both academic and industrial laboratories demonstrates the exponential growth of the use of peptides in the diverse fields of medical science.
Pharmacochemistry Library, Volume 19: Small Peptides: Chemistry, Biology, and Clinical Studies focuses on the processes, reactions, properties, and characteristics of peptides, including analogues and proteases. The publication first takes a look at angiotensin II and bombesin/gastrin-releasing peptide. Topics include conformationally restricted analogues of bombesin, non-peptide antagonists of angiotensin II, receptor subtypes of angiotensin II, and bombesin/GRP antagonists and cancer. The text then elaborates on bradykinin, cholecystokinin, and enkephalin analogues. The manuscript examines luteinizing hormone releasing hormone and somatostatin. Topics include enzymic degradation of somatostatin and analogues, clinical applications of somatostatin analogues, and pharmacological and clinical studies with LHRH agonists and antagonists. The formulation of peptides and inhibitors of aspartyl proteases are also mentioned. The book is a valuable source of information for chemists, biologists, and readers interested in small peptides.
The Peptides: Analysis, Synthesis, Biology, Volume 6: Opioid Peptides: Biology, Chemistry, and Genetics presents a biological topic of peptide research. This book is divided into nine chapters. Chapter 1 reviews the opioid peptide precursors and their genes. The proenkephalin and products of its processing are discussed in Chapter 2. In Chapter 3, the role of pro-opiomelanocortin (POMC) as a protein at the interface of the endocrine and nervous systems is examined. Chapter 4 provides a comprehensive account of the biology and chemistry of the dynorphin peptides. The opioid receptors are described in Chapter 5. Chapter 6 evaluates the structure-activity relationships of ?-endorphin, while Chapter 7 considers the conformational analysis of enkephalins and conformation-activity relationships. The structure-activity relationships among enkephalin peptides are elaborated in Chapter 8. The last chapter is devoted to the clinical significance of opioid peptides in humans. This publication is a good reference for biologists, specialists, and researchers concerned with peptides and proteins.
The Eleventh American Peptide Symposium was held on the San Diego campus of the University of California in picturesque La Jolla on July 9-14, 1989. More than 1100 participants from around the world came to attend a scientific program comprised of an assortment of oral presentations, posters and exhibits. Most rewarding to us was the regular attendance at all the scientific sessions by our registered guests despite the beautiful scenery offered by La Jolla and San Diego county. Indeed for all of us, the purpose of the biennial American Peptide Symposium is to try to keep up with a fast evolving and fascinating field. The goal of the proceedings of these meetings is to provide the scientific community unable to attend some or all of the Eleventh American Peptide Symposium with a synopsis of current results in peptide research. Of 65 oral presentations and approximately 390 poster displays, the Program Committee selected 393 articles for publication. A few manuscripts by distinguished invited speakers were unfortunately not received in time to appear in these proceedings. All manuscripts herein were selected on the basis of their originality at the time of presentation and their significance in the development of peptide-related research. As in the past, this Eleventh meeting brought together scientists with a wide range of expertise, which was harnessed to address and solve basic as well as applied scientific problems in broad areas.
Almost two centuries ago proteins were recognized as the primary materials (proteios = primary) oflife, but the significance and wide role of peptides (from pepsis = digestion) in practically all life pro cesses has only become apparent in the last few decades. Biologi cally active peptides are now being discovered at rapid intervals in the brain and in other organs including the heart, in the skin of amphibians and many other tissues. Peptides and peptide-like compounds are found among toxins and antibiotics. It is unlikely that this process, an almost explosive broadening of the field, will come to a sudden halt. By now it is obvious that Nature has used the combination of a small to moderate number of amino acids to generate a great variety of agonists with specific and often highly sophisticated functions. Thus, peptide chemistry must be regarded as a discipline in its own right, a major branch of biochemistry, fairly separate from the chemistry of proteins. Because of the important role played by synthesis both in the study and in the practical preparation of peptides, their area can be considered as belonging to bio-organic chemistry as well. The already overwhelming and still increasing body of know ledge renders an account of the history of peptide chemistry more and more difficult. It appears therefore timely to look back, to take stock and to recall the important stages in the development of a new discipline.