Chemistry and Biology

Author: Norbert Sewald,Hans-Dieter Jakubke

Publisher: John Wiley & Sons

ISBN: 3527802657

Category: Science

Page: 594

View: 4627

Thoroughly updated, incorporating around 25 % new material, Sewald/Jakubke remains the only modern and scientifically up-to-date advanced textbook on peptide biochemistry, distilling the knowledge of hundreds of publications into a highly readable synopsis of this diverse field. The authors explain the broad fundamentals of peptide synthesis and structure, systematically addressing important families of biologically active peptides, and adopting an interdisciplinary approach that covers application areas in biotechnology, pharmaceutical science, and biomedicine. One major focus is on such "hot" research topics as pseudopeptides, peptidomimetics, and combinatorial synthesis. This new edition also features study questions for each learning unit, for easier self-study and classroom teaching.

Peptides: Chemistry and Biology

Author: J.A. Smith,Jean E. Rivier

Publisher: Springer


Category: Science

Page: 989

View: 982

Proceedings of the Twelfth American Peptide Symposium, June 16-21, 1991, Cambridge, Massachusetts, USA


Chemistry and Biology : Proceedings of the Tenth American Peptide Symposium, May 23-28, 1987, St. Louis, Missouri, U.S.A.

Author: Garland R. Marshall

Publisher: Springer


Category: Science

Page: 690

View: 2613

Peptides: Chemistry and Biology

Author: G.R. Marshall

Publisher: Springer

ISBN: 9789072199010

Category: Science

Page: 724

View: 3898

The Tenth American Peptide Symposium was held on the campus of Wash ington University in St. Louis, Missouri, on May 23-28, 1987. More than 750 participants from around the world met to renew acquaintances, make new friends, and feast at the scientific explosion occurring in the field of peptide research. From over 85 oral presentations and 295 poster presentations, the manuscripts which make up this proceedings have been selected in order to present a synopsis of current research. In many ways, this meeting represented a culmination of forces clearly perceptible in the proceedings of previous meetings in which synthetic chemistry, spectroscopy, molecular biology, molecular modeling, and protein chemistry all are blended as needed to focus on interesting scientific problems. As peptides assume an ever increasingly important role in biological phenomena, our domain as peptide chemists has obviously expanded, and we are the richer for it. The session on conformation was highlighted by both predictions ofthree-dimensional structures of proteins (i. e. , interleukin and human growth hormone) as well as determination of solution structures by 2D NMR. A growing interest in peptide mimetics stimulated much interest in reverse turn mimics, nonpeptide antagonists of peptide hormones, and amide bond isosteres. Increased use of unusual amino acids created strong interest in approaches to asymmetric syntheses of amino acids and methodological improvements in peptide synthesis as well as recent advances in purification and characterization methods.


Chemistry, Structure and Biology

Author: Robert S. Hodges,J.A. Smith

Publisher: Springer

ISBN: 9789072199195

Category: Science

Page: 1160

View: 9199

This unique reference book contains 372 articles selected from 762 plenary lectures, workshops and poster presentations made during the Thirteenth American Peptide Symposium held in Edmonton, Alberta, Canada. The book opens with Nobel Laureate Dr. Bruce Merrifield's `Remarks on Peptide Chemistry' which focus on past scientists and their contributions of peptide chemistry in all aspects of biology, and Dr. Victor Hruby's Pierce Award Lecture on designing peptides, pseudopeptides and peptidomimetics to understand the relationship between structure and biology activity. The contributions are grouped into 14 sections: Synthetic and Analytical Methods Peptide Mimetics Glycopeptides/Lipopeptides Peptide Hormones/Neuropeptides Peptide Inhibitors/Peptide-Receptor Interactions Peptide Vaccines and Immunology Conformational Analysis Peptide Pharmaceuticals/Diagnostics and Peptide Delivery Computational Biochemistry Peptide Macromolecular Interactions Peptide Libraries De novo Design of Peptides and Proteins; and three Workshops: Approaches and Advances in Peptide Synthesis, Purification and Analysis An Introduction to NMR Spectroscopy of Peptides An Introduction to Energy Minimization, Molecular Dynamics, Molecular Modelling and Conformational Analysis of Peptides. This 1200 page compendium of current research from both academic and industrial laboratories demonstrates the exponential growth of the use of peptides in the diverse fields of medical science.


Chemistry, Structure, and Biology : Proceedings of the Fourteenth American Peptide Symposium June 18-23, 1995, Columbus, Ohio,

Author: Pravin T. P. Kaumaya,Robert S. Hodges

Publisher: N.A


Category: Peptides

Page: 935

View: 3350


chemistry, structure, and biology : proceedings of the fourth American Peptide Symposium

Author: Roderich Walter,Johannes Meienhofer

Publisher: Ann Arbor Science Publishers


Category: Science

Page: 1053

View: 5845

Peptides from A to Z

A Concise Encyclopedia

Author: Hans-Dieter Jakubke,Norbert Sewald

Publisher: John Wiley & Sons

ISBN: 9783527621170

Category: Science

Page: 413

View: 6093

This mini-encyclopedia contains more than 1,500 alphabetical entries from the entire field of peptide science in one handy volume, as well as the technical terms, acronyms and concepts used in peptide chemistry. It also features the complete sequence of more than 800 peptides, numerous illustrations and numerous cross-references. Areas covered include: - biological peptides and small proteins - peptide hormones - pharmaceutical peptides - peptide antibiotics - peptide inhibitors - peptide reagents - peptide tags - structural classes - synthesis and purification - analytical methods - proteomics and peptidomics. Condensed yet accessible, only essential information is displayed, extensively linked via references to the recent scientific literature for further study.

Small Peptides

Chemistry, Biology and Clinical Studies

Author: A.S. Dutta

Publisher: Elsevier

ISBN: 1483164632

Category: Medical

Page: 632

View: 722

Pharmacochemistry Library, Volume 19: Small Peptides: Chemistry, Biology, and Clinical Studies focuses on the processes, reactions, properties, and characteristics of peptides, including analogues and proteases. The publication first takes a look at angiotensin II and bombesin/gastrin-releasing peptide. Topics include conformationally restricted analogues of bombesin, non-peptide antagonists of angiotensin II, receptor subtypes of angiotensin II, and bombesin/GRP antagonists and cancer. The text then elaborates on bradykinin, cholecystokinin, and enkephalin analogues. The manuscript examines luteinizing hormone releasing hormone and somatostatin. Topics include enzymic degradation of somatostatin and analogues, clinical applications of somatostatin analogues, and pharmacological and clinical studies with LHRH agonists and antagonists. The formulation of peptides and inhibitors of aspartyl proteases are also mentioned. The book is a valuable source of information for chemists, biologists, and readers interested in small peptides.

Opioid Peptides: Biology, Chemistry, and Genetics

The Peptides: Analysis, Synthesis, Biology

Author: Sidney Udenfriend,Johannes Meienhofer

Publisher: Elsevier

ISBN: 148321799X

Category: Science

Page: 446

View: 8945

The Peptides: Analysis, Synthesis, Biology, Volume 6: Opioid Peptides: Biology, Chemistry, and Genetics presents a biological topic of peptide research. This book is divided into nine chapters. Chapter 1 reviews the opioid peptide precursors and their genes. The proenkephalin and products of its processing are discussed in Chapter 2. In Chapter 3, the role of pro-opiomelanocortin (POMC) as a protein at the interface of the endocrine and nervous systems is examined. Chapter 4 provides a comprehensive account of the biology and chemistry of the dynorphin peptides. The opioid receptors are described in Chapter 5. Chapter 6 evaluates the structure-activity relationships of ?-endorphin, while Chapter 7 considers the conformational analysis of enkephalins and conformation-activity relationships. The structure-activity relationships among enkephalin peptides are elaborated in Chapter 8. The last chapter is devoted to the clinical significance of opioid peptides in humans. This publication is a good reference for biologists, specialists, and researchers concerned with peptides and proteins.

Peptides for Youth

The Proceedings of the 20th American Peptide Symposium

Author: Susan Valle,Emanuel Escher,William D. Lubell

Publisher: Springer Science & Business Media

ISBN: 9780387736570

Category: Science

Page: 643

View: 7606

The American Peptide Society (APS) provides a forum for advancing and promoting knowledge of the chemistry and biology of peptides. The approximately one thousand members of the Society come from North America and from more than thirty other countries throughout the world. Establishment of the APS was a result of the rapid worldwide growth that has occurred in peptide-related research, and of the increasing interaction of peptide scientists with virtually all fields of science. Peptides for Youth: The Proceedings of the the 20th American Peptide Symposium will highlight many of the recent developments in peptide science, with a particular emphasis on how these advances are being applied to basic problems in biology and medicine. The 20th American Peptide Symposium will take place June 26 - 30, 2007 in Montreal, Canada.

The World of Peptides

A Brief History of Peptide Chemistry

Author: Theodor Wieland,Miklos Bodanszky

Publisher: Springer Science & Business Media

ISBN: 3642758509

Category: Science

Page: 298

View: 9135

Almost two centuries ago proteins were recognized as the primary materials (proteios = primary) oflife, but the significance and wide role of peptides (from pepsis = digestion) in practically all life pro cesses has only become apparent in the last few decades. Biologi cally active peptides are now being discovered at rapid intervals in the brain and in other organs including the heart, in the skin of amphibians and many other tissues. Peptides and peptide-like compounds are found among toxins and antibiotics. It is unlikely that this process, an almost explosive broadening of the field, will come to a sudden halt. By now it is obvious that Nature has used the combination of a small to moderate number of amino acids to generate a great variety of agonists with specific and often highly sophisticated functions. Thus, peptide chemistry must be regarded as a discipline in its own right, a major branch of biochemistry, fairly separate from the chemistry of proteins. Because of the important role played by synthesis both in the study and in the practical preparation of peptides, their area can be considered as belonging to bio-organic chemistry as well. The already overwhelming and still increasing body of know ledge renders an account of the history of peptide chemistry more and more difficult. It appears therefore timely to look back, to take stock and to recall the important stages in the development of a new discipline.

Organische Chemie

Studieren kompakt

Author: Paula Yurkanis Bruice

Publisher: Pearson Deutschland GmbH

ISBN: 3868941029


Page: 1165

View: 4689

Molecular Biology and Biotechnology

A Comprehensive Desk Reference

Author: Robert A. Meyers

Publisher: John Wiley & Sons

ISBN: 9780471186342

Category: Medical

Page: 1034

View: 5210

Essential for the top of every desk and laboratory bench, this single volume reference is the first and last resource required to answer any question relating to molecular biology, biotechnology, or molecular medicine. This work contains the theory and techniques for understanding, modifying, manipulating, expressing, and synthesizing biological molecules, conformations, and aggregates. Over 250 carefully reviewed articles written by 378 eminent scientists in the field, provide detailed and readable coverage of today's most relevant topics including life processes at the molecular level, genetic disease diagnosis and genetic therapy, the theory and techniques for understanding, manipulating, and synthesizing biological molecules and their aggregates.

Peptide Chemistry and Drug Design

Author: Ben M. Dunn

Publisher: John Wiley & Sons

ISBN: 1118995287

Category: Medical

Page: 336

View: 4409

This book focuses on peptides as drugs, a growing area ofpharmaceutical research and development. It helps readers solveproblems of discovering, developing, producing, and deliveringpeptide-based drugs. • Identifies promising new areas in peptide drugdiscovery • Includes chapters on discovery from natural sources,metabolic modification, and drug delivery • Overviews separation methods and techniques foranalysis, bond formation, and purification • Offers readers both a professional reference and atext or resource for graduate-level students

Peptides for the New Millennium

Proceedings of the 16th American Peptide Symposium June 26–July 1, 1999, Minneapolis, Minnesota, U.S.A.

Author: Gregg B. Fields,James P. Tam,George Barany

Publisher: Springer Science & Business Media

ISBN: 0792364457

Category: Science

Page: 829

View: 4983

“Have you tried peptides? Small proteins, the best in the land! Won’t you try peptides? Keep all your body processes in hand! For labor and lactation oxytocin you must buy! Enkephalin always gives a good runner’s high! So won’t you try peptides? Small proteins, the best in the land!” The above words [1], penned by Gary Gisselman to open Peptide Ångst: La Triviata, the opera which made its world premiere on July 1, 1999, also serve as a fitting charge to the th 16 American Peptide Symposium. This latest edition of a premier biennial series was held under the auspices of the American Peptide Society, June 26–July 1, 1999, at the Minneapolis Convention Center, Minneapolis,Minnesota, with the undersigned serving as Co-Chairs. The fortunate coincidence of the calendar allowed us to set as the theme “Peptides for the New Millennium”, and in our judgment, the approximately 1200 participants [2] who converged in the Twin Cities from academic and industrial institutions in 36 countries were treated to an exciting and stimulating conference that left most everyone with an enthusiastic vision for the future of our field. The present Proceedings volume should serve as a handy reference source and succinct snapshot of peptide science at essentially its century mark – the clock having started with the initial contributions of Emil Fischer and Th. Curtius.

Combinatorial Peptide and Nonpeptide Libraries

A Handbook

Author: Günther Jung

Publisher: John Wiley & Sons

ISBN: 3527614907

Category: Science

Page: 571

View: 7007

With combinatorial chemistry millions of organic compounds can be produced simultaneously, quickly, and in most cases by automated procedures. These compound libraries are a cost-effective resource for the pharmaceutical industry in their search for biologically active lead structures. Furthermore simultaneous parallel synthesis of single peptides and peptide libraries solve the problem of the worldwide increasing demand for peptides. The synthetic methods described here in detail contribute to a forward-looking technology that has a high impact for industrial and academic research. Fast and efficient analytical techniques are essential for using the complicated product mixtures and detecting by-products. Various synthetic approaches and technologies, mass spectrometry, and screening assays are discussed extensively. This book is a must and an indispensible source of information for every researcher in this rapidly developing field, which spans organic synthesis, biochemistry, biotechnology, pharmaceutical, medicinal, and clinical chemistry.