High-throughput ‘omics’ projects such as genome sequencing, structural genomics and proteomics mean that there is no shortage of information on proteins. But the more information we have, the harder it is to make sense of it, to know where to start, and to identify the important results. This book is a clear, up to date and authoritative account of the principles that govern the way proteins work, and sets proteins within the context in which they function: within the cell, within biological systems, and within the limitations fixed by physics, chemistry, and evolution, taking examples from many different areas of biology. It provides an integrated view of proteins, showing how evolutionary pressure has driven proteins to adopt a domain structure, and to put these domains together in various combinations in order to achieve a biological outcome. It shows how the association of proteins into dimers, complexes (molecular machines) and multi-enzyme complexes allows them to achieve remarkable catalytic and functional efficiency. It shows how evolution has led to an accumulation of regulatory and scaffold proteins, particularly with reference to signaling pathways; and it presents current views of protein dynamics and interactions. For the student it provides a framework, showing where old and new results fit in, and for the postgraduate and researcher it provides an up to date and coherent account of the relationship between protein function, structure and dynamics.
Bruce Alberts,Dennis Bray,Karen Hopkin,Alexander D Johnson,Julian Lewis,Martin Raff,Keith Roberts,Peter Walter
Author: Bruce Alberts,Dennis Bray,Karen Hopkin,Alexander D Johnson,Julian Lewis,Martin Raff,Keith Roberts,Peter Walter
Publisher: Garland Science
Essential Cell Biology provides a readily accessible introduction to the central concepts of cell biology, and its lively, clear writing and exceptional illustrations make it the ideal textbook for a first course in both cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive conceptual framework for the basic science that underlies our current understanding of all of biology, including the biomedical sciences. The Fourth Edition has been thoroughly revised, and covers the latest developments in this fast-moving field, yet retains the academic level and length of the previous edition. The book is accompanied by a rich package of online student and instructor resources, including over 130 narrated movies, an expanded and updated Question Bank. Essential Cell Biology, Fourth Edition is additionally supported by the Garland Science Learning System. This homework platform is designed to evaluate and improve student performance and allows instructors to select assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard. Students receive immediate feedback on their mastery of the topics, and will be better prepared for lectures and classroom discussions. The user-friendly system provides a convenient way to engage students while assessing progress. Performance data can be used to tailor classroom discussion, activities, and lectures to address students’ needs precisely and efficiently. For more information and sample material, visit http://garlandscience.rocketmix.com/.
Marcia F. Bartusiak,Barbara Burke,Andrew Chaikin,Addison Greenwood,T.A. Heppenheimer,Michelle Hoffman,David Holzman,Elizabeth J. Maggio,Anne Simon Moffat,National Academy of Sciences
Author: Marcia F. Bartusiak,Barbara Burke,Andrew Chaikin,Addison Greenwood,T.A. Heppenheimer,Michelle Hoffman,David Holzman,Elizabeth J. Maggio,Anne Simon Moffat,National Academy of Sciences
Publisher: National Academies Press
A Positron Named Priscilla is a book of wonder, offering a fascinating, readable overview of cutting-edge investigations by many of today's leading young scientists. Written for anyone who loves science, this volume reports on some of the most exciting recent discoveries and advances in fields from astronomy to molecular biology. This new book is from one of the world's most prestigious scientific institutions, the National Academy of Sciences. The Academy provides an annual forum for the brightest young investigators to exchange ideas across disciplines--an exchange that was the spark for A Positron Named Priscilla. Each chapter is authored by a popular science writer who offers helpful historical perspectives, clear and well-illustrated explanations of current scientific thinking, and previews of future developments. The scope of topics and breadth of discussion ensure interest at all levels. Topics include Planetary science and the compelling glimpse through the clouded atmosphere of Venus afforded by the spacecraft Magellan. Astrophysics and the emergence of helioseismology, a new field that allows researchers to probe the interior workings of the sun. Biology and what we have learned about DNA in the 40 years since its discovery; our current understanding of protein molecules, the "building blocks" of living systems; and the high-tech search for answers to the AIDS epidemic. Physics and our new-found ability to move and manipulate individual atoms on a surface. The book also tells the remarkable story of "buckyballs," or buckminsterfullerenes, a form of carbon discovered only a few years ago, that have the potential to be used in a variety of important applications, from superconductivity to nanotechnology. Mathematics and the rise of "wavelet" theory, and how mathematicians are applying it in sometimes startling ways, from assisting the FBI with fingerprint storage to coaxing the secrets from a battered recording of Brahms playing the piano. Geosciences and the search for "clocks in the earth" to make life-saving earthquake predictions. A Positron Named Priscilla is a "must" read for anyone who wants to keep up with a broad range of scientific endeavor.
A NATO Advanced Research Workshop entitled New Methods for the Study of Molecular Aggregates was held at Tbe Lodge at Kananaskis Village, Alberta, Canada from 16 -20 June 1996. In fact the meeting was entirely concerned with the problem of analyzing biomolecular complexes, so the title of these proceedings has been altered to give a more precise description of the content. Tbe workshop was hosted by the time-of-flight group of the Department of Physics at the University of Manitoba, and was attended by 64 participants from around the world. '!\venty-one invited talks were given and 27 papers were presented as posters. Of the 48 contributions, 22 papers (12 orals, 10 posters) are included in these proceedings. Tbe subject of the conference was the investigation of noncovalent biomolecular complexes, with particular focus on the application of mass spectrometry to their characterization. '!\vo new ionization techniques introduced in the late 1980s, electrospray ionization (ES I) and matrix-assisted laser desorptionlionization (MALDI), resulted in a breakthrough in mass spectrometry, enabling its use in molecular weight and primary structure determination of biopolymers larger than 100 kDa. Recently it has been discovered that ESI mass spectrometry mayaiso be used to characterize complexes containing noncovalent interactions, thus opening new perspectives for supramolecular chemistry. ESI mass spectrometry has the advantage that the sampie is introduced from a homogenous solution which can be maintained at near physiological conditions of pR, concentration, and temperature.
A coherent introduction to the complete range of soliton theory including Hirota's method and Backlund transformations. Details physical applications of soliton theory with chapters on the peculiar wave patterns of the Andaman Sea, atmospheric phenomena, general relativity and Davydov solitons. Contains testing for full integrability, a discussion of the Painlevé technique, symmetries and conservation law.
Robert Sinclair MacKay,Luis V zquez,Mar¡a Paz Zorzano
Proceedings of the Third Conference : June 17-21 2002, San Lorenzo de El Escorial Madrid
Author: Robert Sinclair MacKay,Luis V zquez,Mar¡a Paz Zorzano
Publisher: World Scientific
This conference was the third meeting organized in the framework of the European LOCNET project. The main topics discussed by this international research collaboration were localization by nonlinearity and spatial discreteness, and energy transfer (in crystals, biomolecules and Josephson arrays).
Wissenschaftlich erprobte Ernährung für ein gesundes und langes Leben - Die Longevità-Diät
Author: Prof. Dr. Valter Longo
Publisher: Goldmann Verlag
Altersforscher Prof. Dr. Valter Longo gibt zum ersten Mal einen umfassenden Überblick über seine bahnbrechenden Forschungsergebnisse, wie man mit der richtigen Ernährung ein gesundes langes Leben erreicht. Er zeigt, wie man Bauchfett reduzieren, körperlich jünger werden und damit das Risiko für Krebs, Herz-Kreislauf-Erkrankungen, Diabetes und Alzheimer senken kann. Außerdem erläutert er die positiven Effekte von Fastenphasen. Seine Longevità-Diät nutzt die heilende Wirkung der Nahrung und revolutioniert unser Verhältnis zum Essen.
By combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
We are in the midst of a revolution. It is a scientific revolution built upon the tools of molecular biology, with which we probe and prod the living world in ways unimaginable a few decades ago. Need to track a bacterium at the root of a hospital outbreak? No problem: the offending germ's complete genetic profile can be obtained in 24 hours. We insert human DNA into E. coli bacteria to produce our insulin. It is natural to look at biotechnology in the 21st century with a mix of wonder and fear. But biotechnology is not as 'unnatural' as one might think. All living organisms use the same molecular processes to replicate their genetic material and the same basic code to 'read' their genes. The similarities can be seen in their DNA. Here, John Archibald shows how evolution has been 'plugging-and-playing' with the subcellular components of life from the very beginning and continues to do so today. For evidence, we need look no further than the inner workings of our own cells. Molecular biology has allowed us to gaze back more than three billion years, revealing the microbial mergers and acquisitions that underpin the development of complex life. One Plus One Equals One tells the story of how we have come to this realization and its implications.
Each chapter of this volume is a contribution from an expert in the field, chosen by the editors to contribute to the 1997 "Current Issues in Blood Substitute Research and Development" course given in San Diego, March 17-19. The contributors were selected because of their expertise in areas which the editors believe to be critical to the advancement of the field, and which reflect activity in "hot" areas of relevant research. While there is a continuity in style for the annual course, each year brings changes in emphasis and content. In previous years, we were often not able to provide time for participants to present their views and opinions. Consequently, this year we encouraged discussion after each presentation. These sessions were recorded, transcribed, and are printed with the chapters herein. We believe that the product is very close to the capturing this year's course in print, and trust readers will enjoy reading the always candid and often provocative remarks from the audience. The price paid for inclusion of the discussion transcriptions was a delay in publication. Each author was allowed to edit his/her discussion section as well as the final version of the chapters prior to publication. The changes are mainly for grammar, and we tried, when possible, not to alter the conversational style of these interchanges.
"Medicines By Design aims to explain how scientists unravel the many different ways medicines work in the body and how this information guides the hunt for drugs of the future. Pharmacology is a broad discipline encompassing every aspect of the study of drugs, including their discovery and development and the testing of their action in the body. Much of the most promising pharmacological research going on at universities across the country is sponsored by the National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health (NIH), U.S. Department of Health and Human Services. Working at the crossroads of chemistry, genetics, cell biology, physiology, and engineering, pharmacologists are fighting disease in the laboratory and at the bedside."--BC Campus website.
More profound understanding of the nature of light and light-matter interactions in biology has enabled many applications in the biology and medical fields. So a new discipline is born, namely biophotonics. The aim of this book is to review the current state-of-the-art of the field by means of authoritative chapters written by the world leaders of the respective fields. This book will be useful not only to professionals, but also to graduate students interested in this field.
Translation Mechanisms provides investigators and graduate students with overviews of recent developments in the field of protein biosynthesis that are fuelled by the explosive and synergic growth of structural biology, genomics, and bioinformatics. The outstanding progress in our understanding of the structure, dynamics, and evolution of the prokaryotic and eukaryotic translation machinery, as well as applications in medicine and biotechnology, are described in 26 chapters covering recent discoveries on: -the subtleties of tRNA aminoacylation with natural and unnatural amino acids. -the control of mRNA stability, a key step of gene regulation. -ribosome structure and function, in the era of the atomic-crystal resolution of the ribosome. -the regulation of the biosynthesis of the translational machinery components. -the action of a variety of inhibitors of translation and the prospect for clinical studies.
Thousands of imaginative scientists, over more than a century,have revealed the fascinating story of intracellular calcium,through a pathway of ingenious invention and discovery. Intracellular Calcium, the definitive book on this topic,reveals: The pathway of discovery and invention of intracellular calciumover more than 100 years. The evidence for intracellular calcium as a universal switch inall animal, plant, fungal and microbial cells How the components required for calcium signalling are namedand classified. The ingenious technology, which has been developed to studyintracellular calcium. How calcium is regulated inside cells and how it works totrigger an event. The role of intracellular calcium in disease, cell injury andcell death. How many drugs work through the calcium signalling system. How intracellular calcium is involved in the action of manynatural toxins. How the intracellular calcium signalling system has evolvedover 4000 million years, showing why it was crucial to the originof life. A key principle presented throughout the book is the molecularvariation upon which the intracellular calcium signalling systemdepends. This variation occurs within the same cell type andbetween cells with different functions, providing the invisiblematrix upon which Darwin and Wallace’s Natural Selectiondepends. Featuring more than 100 figures, including detailed chemicalstructures as well as pictures of key pioneers in the field, abibliography of more than 1500 references, as well asdetailed subject and organism indices, this definitive workprovides a unique source of scholarship for teachers andresearchers in the biomedical sciences and beyond.
Following the succesful publication of "Proteome and Protein Analysis" in 2000, which was based on a former MPSA (Methods in Protein Structure Analysis) conference, "Methods in Proteome and Protein Analysis" presents the most interesting papers from the 14th MPSA meeting. Selected contributions discuss the latest techniques and approaches for analysing protein and proteome structures. Major topics include: protein and peptide sample preparation and separation new reagent for protein sequence analysis mass spectrometry in protein research analysis of posttranslational modification protein-protein interaction using MALDI-MS manipulation of genome or functional compositon trap structure-function correlation study using optical biosensors of microcolorimetrical techniques structural proteomics as NMR or fluorescence polarization study the classification and prediction of structure or functional sites in silico analysis of proteins and proteomes increasing throughput and data quality for proteomics
This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.
Arnold Berk,David Baltimore,Harvey Lodish,James Darnell,Paul Matsudaira,S. Lawrence Zipursky
Verliere bis zu einem Pfund pro Tag, ohne zu hungern, und erlange deine Energie und Lebensfreude zurück
Author: Dave Asprey
Publisher: Riva Verlag
Category: Health & Fitness
Mit Mitte 20 war Dave Asprey ein erfolgreicher Unternehmer im Silicon Valley und Multimillionär. Doch er wog auch 140 Kilo, und das obwohl er der Empfehlung seiner Ärzte folgte, an sechs Tagen pro Woche nur 1800 Kalorien zu essen und 90 Minuten zu trainieren. Als sein Übergewicht ihm zunehmend die Sinne zu vernebeln begann und Heißhungerattacken ihm Energie und Willenskraft raubten, fing Asprey an, die Technologien, mit denen er reich geworden war, selbst zu nutzen, um seine eigene Biologie zu "hacken". Er investierte 15 Jahre und 300?000 Dollar in alle erdenklichen Testverfahren und Selbstversuche, vom EEG bis zu einem Aufenthalt in einem tibetischen Kloster, um herauszufinden, wie er seinem Körper und Geist ein maximales Upgrade verschaffen konnte. Bulletproof – auf Deutsch "kugelsicher" oder "unverwundbar" – nennt er den Status, in dem man konstante Höchstleistung bringen kann, ohne auszubrennen oder krank zu werden. Asprey gelang es, seinen IQ um mehr als 20 Punkte zu erhöhen, sein biologisches Alter zu senken und ohne Kalorienzählen oder Sport 50 Kilo abzunehmen. Seine vielfältigen Erkenntnisse versammelt er in diesem Buch. Die Bulletproof-Diät hemmt entzündliche Prozesse im Körper, sorgt für schnellen, hungerfreien Gewichtsverlust und höchste Leistungsfähigkeit. Anstelle eines Frühstücks gibt es den berühmten Bulletproof-Kaffee mit Kokosöl und Butter, der lange sättigt und einen dauerhaften Energieschub verschafft. Kalorienzählen ist nicht nötig und auch bei weniger Schlaf und weniger Sport wird das überschüssige Fett nur so dahinschmelzen.
An Updated Edition of the Classic Text Polymers constitute the basis for the plastics, rubber, adhesives,fiber, and coating industries. The Fourth Edition of Introductionto Physical Polymer Science acknowledges the industrial success ofpolymers and the advancements made in the field while continuing todeliver the comprehensive introduction to polymer science that madeits predecessors classic texts. The Fourth Edition continues its coverage of amorphous andcrystalline materials, glass transitions, rubber elasticity, andmechanical behavior, and offers updated discussions of polymerblends, composites, and interfaces, as well as such basics asmolecular weight determination. Thus, interrelationships amongmolecular structure, morphology, and mechanical behavior ofpolymers continue to provide much of the value of the book. Newly introduced topics include: * Nanocomposites, including carbon nanotubes and exfoliatedmontmorillonite clays * The structure, motions, and functions of DNA and proteins, aswell as the interfaces of polymeric biomaterials with livingorganisms * The glass transition behavior of nano-thin plastic films In addition, new sections have been included on fire retardancy,friction and wear, optical tweezers, and more. Introduction to Physical Polymer Science, Fourth Edition providesboth an essential introduction to the field as well as an entrypoint to the latest research and developments in polymer scienceand engineering, making it an indispensable text for chemistry,chemical engineering, materials science and engineering, andpolymer science and engineering students and professionals.