Gene Therapy: Prospective Technology assessment in its societal context

Author: Jörg Niewöhner

Publisher: Elsevier


Category: Technology & Engineering

Page: 274

View: 566

This book presents work that has been conducted as part of the research project "Discourse on ethical questions of biomedicine" of the interdisciplinary Working Group Bioethics and Science Communication at the Max-Delbrueck-Center for Molecular Medicine (MDC)in Berlin-Buch, Germany. This book offers ground-breaking ideas on how the daily interworking of cutting-edge biomedical research assess the broader social context and its communication to stakeholders and the public. Editors cover three aspects: Scientific, Ethical and Legal, and Perception and Communication. This work establishes an international and interdisciplinary network of excellent researchers at the beginning of their careers, who brilliantly integrate their work into the different perspectives on gene therapy from the natural and social sciences, as well as the humanities and law. * Discusses biological and cellular barriers limiting the clinical application of nonviral gene delivery systems * Addresses such questions as: Does patent granting hinder the development of Gene Therapy products? * Offers insight in the future of public perception of gene therapy in Europe * Provides details on how to communicate risks in gene therapy

Encyclopedia of Health Services Research

Ed. by Ross M. Mullner

Author: Ross M. Mullner

Publisher: SAGE


Category: Medical

Page: 1456

View: 984

At the very heart of modern healthcare is a critical paradox. Today, as never before, healthcare has the ability to enhance the quality and duration of life. At the same time, healthcare has become so enormously costly that it can easily bankrupt governments and impoverish individuals and families. According to federal forecasters, by the year 2015 one in every five U.S. dollars will be spent on healthcare, for total annual healthcare spending of more than $4 trillion. While the cost of healthcare is going up, the number of individuals and families without health insurance coverage is increasing. For many, the miracles of modern medicine may be unaffordable. Health services research investigates the relationship between the factors of cost, quality, and access to healthcare and their impact upon medical outcomes (i.e., death, disease, disability, discomfort, and dissatisfaction with care). Health services research addresses such key questions as, Why is the cost of healthcare always increasing? How can healthcare costs be successfully contained without jeopardizing quality? How can medical errors be eliminated? What is the medical impact of not having health insurance coverage? The proposed encyclopedia addresses these and other important questions and issues.

Introduction to Biosemiotics

The New Biological Synthesis

Author: Marcello Barbieri

Publisher: Springer Science & Business Media


Category: Science

Page: 530

View: 762

Combining research approaches from biology, philosophy and linguistics, the field of Biosemiotics proposes that animals, plants and single cells all engage in semiosis – the conversion of objective signals into conventional signs. This has important implications and applications for issues ranging from natural selection to animal behavior and human psychology, leaving biosemiotics at the cutting edge of the research on the fundamentals of life. Drawing on an international expertise, the book details the history and study of biosemiotics, and provides a state-of-the-art summary of the current work in this new field. And, with relevance to a wide range of disciplines – from linguistics and semiotics to evolutionary phenomena and the philosophy of biology – the book provides an important text for both students and established researchers, while marking a vital step in the evolution of a new biological paradigm.

Bio-synthetic Polymer Conjugates

Author: Helmut Schlaad

Publisher: Springer


Category: Technology & Engineering

Page: 196

View: 743

Polypeptide-Polymer Conjugates, by Henning Menzel Chemical Strategies for the Synthesis of Protein-Polymer Conjugates, by Björn Jung and Patrick Theato Glycopolymer Conjugates, by Ahmed M. Eissa and Neil R. Cameron DNA-Polymer Conjugates: From Synthesis, Through Complex Formation and Self-assembly to Applications, by Dawid Kedracki, Ilyès Safir, Nidhi Gour, Kien Xuan Ngo and Corinne Vebert-Nardin Synthesis of Terpene-Based Polymers, by Junpeng Zhao and Helmut Schlaad

Chemistry of Bioconjugates

Synthesis, Characterization, and Biomedical Applications

Author: Ravin Narain

Publisher: John Wiley & Sons


Category: Science

Page: 496

View: 488

Explores bioconjugate properties and applications ofpolymers, dendrimers, lipids, nanoparticles, and nanotubes Bioconjugation has enabled breakthroughs across many areas ofindustry and biomedicine. With its emphasis on synthesis,properties and applications, this book enables readers tounderstand the connection between chemistry and the biologicalapplication of bioconjugated materials. Its detailed descriptionsof methods make it possible for researchers to fabricate and takefull advantage of bioconjugates for a broad range of applications.Moreover, the book sets the foundation for the development of newapplications, including assays, imaging, biosensors, drug delivery,and diagnostics. Chemistry of Bioconjugates features contributions from aninternational team of leading experts and pioneers in the field.These contributions reflect the authors’ firsthand laboratoryexperience as well as a thorough review of the current literature.The book’s six sections examine: General methods of bioconjugation Polymer bioconjugates Organic nanoparticle-based bioconjugates Inorganic nanomaterial bioconjugates, including metals andmetal oxides Cell-based, hydrogel/microgel, and glyco-bioconjugates Characterization, physico-(bio)chemical properties, andapplications of bioconjugates This comprehensive exploration of bioconjugates includesdiscussions of polymers, dendrimers, lipids, nanoparticles, andnanotubes. References at the end of each chapter serve as a gatewayto the most important original research findings and reviews in thefield. By drawing together and analyzing all the latest chemicalmethods and research findings on the physico-chemical andbiochemical properties of bioconjugates, Chemistry ofBioconjugates sheds new light on the significance and potentialof bioconjugation. The book is recommended for organic and polymerchemists, biochemists, biomaterial scientists, carbohydratechemists, biophysicists, bioengineers, and drug and gene deliveryscientists.

Human Germline Gene Therapy

Scientific, Moral, and Political Issues

Author: David B. Resnik

Publisher: R G Landes Company


Category: Medical

Page: 189

View: 542

Introduction to Risk Calculation in Genetic Counseling

Author: Ian D. Young

Publisher: Oxford University Press


Category: Medical

Page: 256

View: 394

The process of genetic counseling involves many key components, such as taking a family genetic history, making a diagnosis, and providing communication and support to the family. Among these core processes is the mathematical calculation of the actual risk of a possible genetic disorder. For most physicians and counselors, the mathematics and statistics involved can be major challenge which is not always helped by complex computer programs or lengthy papers full of elaborate formulae. In this clear, reader-friendly guide, Ian Young addresses this problem and demonstrates how risk can be estimated for inherited disorders using a basic knowledge of the laws of probability and their application to clinical problems. The text employs a wealth of clearly explained examples and key points in order to guide the reader to an accurate assessment of the risk of genetic disease. It primarily will appeal to genetic counselors, geneticists, and all those involved in providing medical genetic services. In this new edition, Dr. Young has pruned redundancies and extensively updated the concepts in each of the 10 chapters, and he has included more working examples, a popular feature of the book.

Human Nature and Public Policy

An Evolutionary Approach

Author: Albert Somit

Publisher: Macmillan


Category: Political Science

Page: 266

View: 878

Arguing for an evolutionary perspective, this text directly challenges the standard social science model (SSSM) on which public policy has often been based. The SSSM maintains that human behaviour is solely the product of culture and learning. In sharp contrast, the evolutionary model (EM) holds that our behaviour flows from the interaction between learning and culture, on the one hand, and biological factors - especially our evolutionary legacy - on the other. These different approaches to human behaviour understandably lead to divergent conceptions of sound domestic and foreign policy. The SSSM views human behaviour as essentially plastic and thus readily changed by governmental action. Disagreeing, the evolutionary model sees that malleability as seriously limited by our species' evolved propensity for aggression, status seeking, xenophobia, ethnocentrism and hierarchical social structures.

Conceptualizing Technological Change

Theoretical and Empirical Explorations

Author: Govindan Parayil

Publisher: Rowman & Littlefield


Category: Social Science

Page: 220

View: 448

In this original and thoughtful book, Govindan Parayil draws together current scholarship from disciplines ranging from history to economics to sociology as he develops a cohesive theory of technological change. Drawing on a detailed case study of the Green Revolution in Indian agriculture, Parayil convincingly argues that technological change is contingent upon the social-historical process of knowledge change.