Gene Therapy: Prospective Technology assessment in its societal context

Author: Jörg Niewöhner,Christof Tannert

Publisher: Elsevier

ISBN: 9780080470931

Category: Technology & Engineering

Page: 274

View: 604

This book presents work that has been conducted as part of the research project "Discourse on ethical questions of biomedicine" of the interdisciplinary Working Group Bioethics and Science Communication at the Max-Delbrueck-Center for Molecular Medicine (MDC)in Berlin-Buch, Germany. This book offers ground-breaking ideas on how the daily interworking of cutting-edge biomedical research assess the broader social context and its communication to stakeholders and the public. Editors cover three aspects: Scientific, Ethical and Legal, and Perception and Communication. This work establishes an international and interdisciplinary network of excellent researchers at the beginning of their careers, who brilliantly integrate their work into the different perspectives on gene therapy from the natural and social sciences, as well as the humanities and law. * Discusses biological and cellular barriers limiting the clinical application of nonviral gene delivery systems * Addresses such questions as: Does patent granting hinder the development of Gene Therapy products? * Offers insight in the future of public perception of gene therapy in Europe * Provides details on how to communicate risks in gene therapy

Encyclopedia of Health Services Research

Ed. by Ross M. Mullner

Author: Ross M. Mullner

Publisher: SAGE

ISBN: 1412951798

Category: Medical

Page: 1456

View: 1499

At the very heart of modern healthcare is a critical paradox. Today, as never before, healthcare has the ability to enhance the quality and duration of life. At the same time, healthcare has become so enormously costly that it can easily bankrupt governments and impoverish individuals and families. According to federal forecasters, by the year 2015 one in every five U.S. dollars will be spent on healthcare, for total annual healthcare spending of more than $4 trillion. While the cost of healthcare is going up, the number of individuals and families without health insurance coverage is increasing. For many, the miracles of modern medicine may be unaffordable. Health services research investigates the relationship between the factors of cost, quality, and access to healthcare and their impact upon medical outcomes (i.e., death, disease, disability, discomfort, and dissatisfaction with care). Health services research addresses such key questions as, Why is the cost of healthcare always increasing? How can healthcare costs be successfully contained without jeopardizing quality? How can medical errors be eliminated? What is the medical impact of not having health insurance coverage? The proposed encyclopedia addresses these and other important questions and issues.

Introduction to Biosemiotics

The New Biological Synthesis

Author: Marcello Barbieri

Publisher: Springer Science & Business Media

ISBN: 1402048149

Category: Science

Page: 530

View: 9933

Combining research approaches from biology, philosophy and linguistics, the field of Biosemiotics proposes that animals, plants and single cells all engage in semiosis – the conversion of objective signals into conventional signs. This has important implications and applications for issues ranging from natural selection to animal behavior and human psychology, leaving biosemiotics at the cutting edge of the research on the fundamentals of life. Drawing on an international expertise, the book details the history and study of biosemiotics, and provides a state-of-the-art summary of the current work in this new field. And, with relevance to a wide range of disciplines – from linguistics and semiotics to evolutionary phenomena and the philosophy of biology – the book provides an important text for both students and established researchers, while marking a vital step in the evolution of a new biological paradigm.

Bio-synthetic Polymer Conjugates

Author: Helmut Schlaad

Publisher: Springer

ISBN: 3642343503

Category: Technology & Engineering

Page: 196

View: 5309

Polypeptide-Polymer Conjugates, by Henning Menzel Chemical Strategies for the Synthesis of Protein-Polymer Conjugates, by Björn Jung and Patrick Theato Glycopolymer Conjugates, by Ahmed M. Eissa and Neil R. Cameron DNA-Polymer Conjugates: From Synthesis, Through Complex Formation and Self-assembly to Applications, by Dawid Kedracki, Ilyès Safir, Nidhi Gour, Kien Xuan Ngo and Corinne Vebert-Nardin Synthesis of Terpene-Based Polymers, by Junpeng Zhao and Helmut Schlaad

Chemistry of Bioconjugates

Synthesis, Characterization, and Biomedical Applications

Author: Ravin Narain

Publisher: John Wiley & Sons

ISBN: 1118776372

Category: Science

Page: 496

View: 6383

Explores bioconjugate properties and applications of polymers, dendrimers, lipids, nanoparticles, and nanotubes Bioconjugation has enabled breakthroughs across many areas of industry and biomedicine. With its emphasis on synthesis, properties and applications, this book enables readers to understand the connection between chemistry and the biological application of bioconjugated materials. Its detailed descriptions of methods make it possible for researchers to fabricate and take full advantage of bioconjugates for a broad range of applications. Moreover, the book sets the foundation for the development of new applications, including assays, imaging, biosensors, drug delivery, and diagnostics. Chemistry of Bioconjugates features contributions from an international team of leading experts and pioneers in the field. These contributions reflect the authors’ firsthand laboratory experience as well as a thorough review of the current literature. The book’s six sections examine: General methods of bioconjugation Polymer bioconjugates Organic nanoparticle-based bioconjugates Inorganic nanomaterial bioconjugates, including metals and metal oxides Cell-based, hydrogel/microgel, and glyco-bioconjugates Characterization, physico-(bio)chemical properties, and applications of bioconjugates This comprehensive exploration of bioconjugates includes discussions of polymers, dendrimers, lipids, nanoparticles, and nanotubes. References at the end of each chapter serve as a gateway to the most important original research findings and reviews in the field. By drawing together and analyzing all the latest chemical methods and research findings on the physico-chemical and biochemical properties of bioconjugates, Chemistry of Bioconjugates sheds new light on the significance and potential of bioconjugation. The book is recommended for organic and polymer chemists, biochemists, biomaterial scientists, carbohydrate chemists, biophysicists, bioengineers, and drug and gene delivery scientists.

Human Germline Gene Therapy

Scientific, Moral, and Political Issues

Author: David B. Resnik,Holly B. Steinkraus,Pamela J. Langer

Publisher: R G Landes Company

ISBN: 9781570595868

Category: Medical

Page: 189

View: 8122

Introduction to Risk Calculation in Genetic Counseling

Author: Ian D. Young

Publisher: Oxford University Press

ISBN: 9780199748303

Category: Medical

Page: 256

View: 2136

The process of genetic counseling involves many key components, such as taking a family genetic history, making a diagnosis, and providing communication and support to the family. Among these core processes is the mathematical calculation of the actual risk of a possible genetic disorder. For most physicians and counselors, the mathematics and statistics involved can be major challenge which is not always helped by complex computer programs or lengthy papers full of elaborate formulae. In this clear, reader-friendly guide, Ian Young addresses this problem and demonstrates how risk can be estimated for inherited disorders using a basic knowledge of the laws of probability and their application to clinical problems. The text employs a wealth of clearly explained examples and key points in order to guide the reader to an accurate assessment of the risk of genetic disease. It primarily will appeal to genetic counselors, geneticists, and all those involved in providing medical genetic services. In this new edition, Dr. Young has pruned redundancies and extensively updated the concepts in each of the 10 chapters, and he has included more working examples, a popular feature of the book.


Author: Piers Benn

Publisher: McGill-Queen's Press - MQUP

ISBN: 9780773517011

Category: Philosophy

Page: 223

View: 3180

In this engaged and engaging survey Piers Benn examines the major currents of ethical theory, concentrating on sound reasoning about morality. Benn's account offers a qualified defence of Aristotelian virtue theory, while bringing out what is distinctive and valuable in a broad range of approaches, such as those of Kant and the Utilitarians. His examples emphasize the ordinary choices of everyday life - gossip, friendship, honesty, sexual relations, work, and self-realization.

Human Nature and Public Policy

An Evolutionary Approach

Author: Albert Somit,Steven A. Peterson

Publisher: Macmillan

ISBN: 9781403962850

Category: Political Science

Page: 266

View: 8179

Arguing for an evolutionary perspective, this text directly challenges the standard social science model (SSSM) on which public policy has often been based. The SSSM maintains that human behaviour is solely the product of culture and learning. In sharp contrast, the evolutionary model (EM) holds that our behaviour flows from the interaction between learning and culture, on the one hand, and biological factors - especially our evolutionary legacy - on the other. These different approaches to human behaviour understandably lead to divergent conceptions of sound domestic and foreign policy. The SSSM views human behaviour as essentially plastic and thus readily changed by governmental action. Disagreeing, the evolutionary model sees that malleability as seriously limited by our species' evolved propensity for aggression, status seeking, xenophobia, ethnocentrism and hierarchical social structures.

The British National Bibliography

Author: Arthur James Wells

Publisher: N.A


Category: English literature

Page: N.A

View: 2579

Conceptualizing Technological Change

Theoretical and Empirical Explorations

Author: Govindan Parayil

Publisher: Rowman & Littlefield

ISBN: 9780742520042

Category: Social Science

Page: 220

View: 5040

In this original and thoughtful book, Govindan Parayil draws together current scholarship from disciplines ranging from history to economics to sociology as he develops a cohesive theory of technological change. Drawing on a detailed case study of the Green Revolution in Indian agriculture, Parayil convincingly argues that technological change is contingent upon the social-historical process of knowledge change.

The Case against Perfection

Author: Michael J Sandel

Publisher: Harvard University Press

ISBN: 0674043065

Category: Philosophy

Page: 176

View: 6565

The Selfish Gene

Author: Richard Dawkins

Publisher: Oxford University Press, USA

ISBN: 9780192860927

Category: Literary Criticism

Page: 352

View: 3729

An ethologist shows man to be a gene machine whose world is one of savage competition and deceit

Patient Involvement in Health Technology Assessment

Author: Karen Facey,Helle Ploug Hansen,Ann Single

Publisher: Springer

ISBN: 9811040680

Category: Medical

Page: 430

View: 9638

This is the first book to offer a comprehensive guide to involving patients in health technology assessment (HTA). Defining patient involvement as patient participation in the HTA process and research into patient aspects, this book includes detailed explanations of approaches to participation and research, as well as case studies. Patient Involvement in HTA enables researchers, postgraduate students, HTA professionals and experts in the HTA community to study these complementary ways of taking account of patients’ knowledge, experiences, needs and preferences. Part I includes chapters discussing the ethical rationale, terminology, patient-based evidence, participation and patient input. Part II sets out methodology including: Qualitative Evidence Synthesis, Discrete Choice Experiments, Analytical Hierarchy Processes, Ethnographic Fieldwork, Deliberative Methods, Social Media Analysis, Patient-Reported Outcome Measures, patients as collaborative research partners and evaluation. Part III contains 15 case studies setting out current activities by HTA bodies on five continents, health technology developers and patient organisations. Each part includes discussion chapters from leading experts in patient involvement. A final chapter reflects on the need to clearly define the goals for patient involvement within the context of the HTA to identify the optimal approach. With cohesive contributions from more than 80 authors from a variety of disciplines around the globe, it is hoped this book will serve as a catalyst for collaboration to further develop patient involvement to improve HTA. "If you’re not involving patients, you're not doing HTA!" - Dr. Brian O’Rourke, President and CEO of CADTH, Chair of INAHTA

Nutrition in the Prevention and Treatment of Disease

Author: Ann M. Coulston,Carol J. Boushey,Mario Ferruzzi,Linda Delahanty

Publisher: Academic Press

ISBN: 0128029471

Category: Technology & Engineering

Page: 1072

View: 2266

Nutrition in the Prevention and Treatment of Disease, Fourth Edition, is a compilation of current knowledge in clinical nutrition and an overview of the rationale and science base of its application to practice in the prevention and treatment of disease. In its fourth edition, this text continues the tradition of incorporating new discoveries and methods related to this important area of research Generating and analyzing data that summarize dietary intake and its association with disease are valuable tasks in treating disease and developing disease prevention strategies. Well-founded medical nutrition therapies can minimize disease development and related complications. Providing scientifically sound, creative, and effective nutrition interventions is both challenging and rewarding. Two new chapters on metabolomics and translational research, which have come to be used in nutrition research in recent years. The new areas of study are discussed with the perspective that the application of the scientific method is by definition an evolutionary process. A new chapter on Genetics and Diabetes which reviews the latest research on causal genetic variants and biological mechanisms responsible for the disease, and explores potential interactions with environmental factors such as diet and lifestyle. Includes all major "omics" – the exposome, metabolomics, genomics, and the gut microbiome. Expands the microbiota portions to reflect complexity of diet on gut microbial ecology, metabolism and health

The Ethics of Human Gene Therapy

Author: LeRoy Walters,Joseph P Kennedy Professor of Christian Ethics at the Kennedy Institute of Ethics LeRoy Walters,Julie Gage Palmer,Julie G. Palmer

Publisher: Oxford University Press, USA

ISBN: 9780195059557

Category: Medical

Page: 209

View: 4850

The authors of this absorbing new book describe the science of gene therapy in terms easily accessible to the non-specialist, and focus on the controversial ethical and public policy issues surrounding human interventions in human heredity. After a brief survey of the structure and functions of DNA, genes, and cells, Walters and Palmer discuss three major types of potential genetic intervention: somatic cell gene therapy, germ line gene therapy, and genetic enhancements. They start with the current techniques of gene addition, using non-reproductive (somatic) cells in an effort to cure or treat disease. Next they address the technical problems and moral issues facing attempts to prevent disease through genetically modifying early human embryos or sperm and egg cells. These changes would be passed on to future generations. Chapter 4, in many ways the most original part of this volume, confronts the issue of employing genetic means to improve human abilities and appearance. Depending on the techniques employed, such enhancements could affect not only the individuals receiving the intervention but their offspring as well. Three types of genetic enhancements are considered: physical alterations to improve size, reduce the need for sleep, and decelerate aging; intellectual enhancements of memory and general cognitive ability; and moral enhancements for control of violently aggressive behavior. The authors maintain that genetic modifications should be evaluated individually rather than be condemned in principle or as a group. The final chapter summarizes the public review process that human gene therapy proposals have been undergoing in the United States since 1990. Five appendices, providing technical background information along with a complete list of questions raised in the national public review process, supplement the discussion.

Action, Ability and Health

Essays in the Philosophy of Action and Welfare

Author: L.Y Nordenfelt

Publisher: Springer

ISBN: 9780792362067

Category: Medical

Page: 173

View: 1705

This book is a contribution to the general philosophy of action and the philosophy of welfare. The author makes separate analyses of concepts such as action, ability, interaction, action-explanation, happiness, health, illness and disability. At the same time he explores and substantiates the idea of a strong interdependence between the concept of action and some of the central concepts of welfare, in particular health and illness and related concepts.

Human gene therapy.

Author: N.A

Publisher: DIANE Publishing

ISBN: 1428923713


Page: N.A

View: 6279


Law, Policy, and Ethical Issues

Author: Lori P. Knowles,Gregory E. Kaebnick

Publisher: JHU Press

ISBN: 9780801896859

Category: Medical

Page: 320

View: 4505

Concluding with a cautionary call for increased regulation, Reprogenetics introduces fact, history, and reason into a public discussion of complex and vexing issues.

Stem Cell and Gene Therapy for Cardiovascular Disease

Author: Emerson C. Perin,Leslie W. Miller,Doris Taylor,James T. Willerson

Publisher: Academic Press

ISBN: 0128018631

Category: Science

Page: 538

View: 6985

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals