For Students of Pharmacy, Medicinal Chemistry and Biological Chemistry
Author: Paul M. Dewick
Publisher: John Wiley & Sons
Essentials of Organic Chemistry is an accessible introduction tothe subject for students of Pharmacy, Medicinal Chemistry andBiological Chemistry. Designed to provide a thorough grounding infundamental chemical principles, the book focuses on key elementsof organic chemistry and carefully chosen material is illustratedwith the extensive use of pharmaceutical and biochemicalexamples. In order to establish links and similarities the book placesprominence on principles and deductive reasoning withcross-referencing. This informal text also places the main emphasison understanding and predicting reactivity rather than syntheticmethodology as well as utilising a mechanism based layout andfeaturing annotated schemes to reduce the need for textualexplanations. * tailored specifically to the needs of students of PharmacyMedical Chemistry and Biological Chemistry * numerous pharmaceutical and biochemical examples * mechanism based layout * focus on principles and deductive reasoning This will be an invaluable reference for students of PharmacyMedicinal and Biological Chemistry.
Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine. There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions: a comprehensive treatment of plant, microbial, and animal natural products in one volume extensive use of chemical schemes with annotated mechanistic explanations cross-referencing to emphasize links and similarities boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.
The production of textile materials comprises a very large and complex global industry that utilises a diverse range of fibre types and creates a variety of textile products. As the great majority of such products are coloured, predominantly using aqueous dyeing processes, the coloration of textiles is a large-scale global business in which complex procedures are used to apply different types of dye to the various types of textile material. The development of such dyeing processes is the result of substantial research activity, undertaken over many decades, into the physico-chemical aspects of dye adsorption and the establishment of ‘dyeing theory’, which seeks to describe the mechanism by which dyes interact with textile fibres. Physico-Chemical Aspects of Textile Coloration provides a comprehensive treatment of the physical chemistry involved in the dyeing of the major types of natural, man-made and synthetic fibres with the principal types of dye. The book covers: fundamental aspects of the physical and chemical structure of both fibres and dyes, together with the structure and properties of water, in relation to dyeing; dyeing as an area of study as well as the terminology employed in dyeing technology and science; contemporary views of intermolecular forces and the nature of the interactions that can occur between dyes and fibres at a molecular level; fundamental principles involved in dyeing theory, as represented by the thermodynamics and kinetics of dye sorption; detailed accounts of the mechanism of dyeing that applies to cotton (and other cellulosic fibres), polyester, polyamide, wool, polyacrylonitrile and silk fibres; non-aqueous dyeing, as represented by the use of air, organic solvents and supercritical CO2 fluid as alternatives to water as application medium. The up-to-date text is supported by a large number of tables, figures and illustrations as well as footnotes and widespread use of references to published work. The book is essential reading for students, teachers, researchers and professionals involved in textile coloration.
Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies. This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes.
For Students of Pharmacy, Pharmaceutical Sciences and Medicinal Chemistry
Author: Katja A. Strohfeldt
Publisher: John Wiley & Sons
A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.
Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or treat life-threatening conditions such as HIV or cancer. Examining how drugs are manufactured, formulated, and the way that they work in our bodies, Pharmaceutical Chemistry provides a wide-ranging overview of organic chemistry as it is applied to the study and practice of pharmacy. FEATURES * Supports an integrated pharmacy education * Focuses on the fundamental ideas that first-year students need to fully grasp before progressing in their studies * Demonstrates the connections between scientific concepts and principles and how they are applied to pharmacy * Written and edited by experts who have a wealth of teaching experience COMPANION WEBSITE For registered adopters of the book: - Figures from the book, available to download For students: - Self-assessment questions for each chapter - Related additional resources ABOUT THE SERIES The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. Students will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices.
Provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style. The title begins by reviewing the structures and nomenclature of the more common classes of naturally occurring compounds found in biological organisms. An overview of medicinal chemistry is followed by chapters covering the discovery and design of drugs, pharmacokinetics and drug metabolism, The book concludes with a chapter on organic synthesis, followed by a brief look at drug development from the research stage through to marketing the final product. The text assumes little in the way of prior biological knowledge. relevant biology is included through biological topics, examples and the Appendices. Incorporates summary sections, examples, applications and problems Each chapter contains an additional summary section and solutions to the questions are provided at the end of the text Invaluable for undergraduates studying within the chemical, pharmaceutical and life sciences.
Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams. Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material
An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.
An innovative text from a highly experienced instructor, Denise Guinns Essentials of General, Organic, and Biochemistry offers a truly integrated approach to the course, with organic and biochemistry thoughtfully woven into every chapter. With its numerous connections between chemical concepts and health care applications, cases from clinical practice, and problem-solving support, Essentials of GOB provides students everything they need to learn the fundamentals of chemistry in the context of their future careers.