Handbook of Epigenetics

The New Molecular and Medical Genetics

Author: Trygve Tollefsbol

Publisher: Academic Press

ISBN: 0128054778

Category: Science

Page: 682

View: 8367

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Epigenetik – Grundlagen und klinische Bedeutung

Aus der Vortragsreihe der Medizinischen Gesellschaft Mainz e.V.

Author: Hendrik Lehnert,Henriette Kirchner,Ina Kirmes,Ralf Dahm

Publisher: Springer-Verlag

ISBN: 3662540231

Category: Medical

Page: 46

View: 5071

Das vorliegende Buch gibt einen kurzen Überblick über die neuesten Erkenntnisse auf dem spannenden Gebiet der Epigenetik. Es wird erklärt, wie die Epigenetik das Schicksal von Zellen bestimmt, unserem Genom Komplexität verleiht und wie die Epigenetik Informationen der Umwelt für das Genom übersetzt.

Epigenetics in Human Disease

Author: Trygve Tollefsbol

Publisher: Academic Press

ISBN: 012812329X

Category: Medical

Page: 1110

View: 7477

Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders. Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways Provides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more

Gesundheit ist kein Zufall

Wie das Leben unsere Gene prägt - Die neuesten Erkenntnisse der Epigenetik

Author: Peter Spork

Publisher: DVA

ISBN: 3641198194

Category: Science

Page: 416

View: 1679

Warum unsere Gesundheit bei den Großeltern beginnt und bei den Enkeln nicht endet Noch weitgehend unbemerkt von der Öffentlichkeit ändert sich derzeit das Verständnis der Fachwelt von dem, was Gesundheit ist und wie die sogenannten Volkskrankheiten entstehen. Bahnbrechende neue Erkenntnisse der modernen Biologie zeigen: Gesundheit ist kein Zustand. Gesundheit ist auch nicht das Gegenteil von Krankheit. Wir werden nicht gesund oder krank geboren. Gesundheit ist ein andauernder Prozess. Die Zellen des Körpers arbeiten unentwegt gegen Alterung und Krankheit. Sie erinnern sich dabei an Umwelteinflüsse und die Folgen des eigenen Lebensstils. Sogar die Erfahrungen der Eltern und Großeltern, deren Ernährungsgewohnheiten oder seelischen Belastungen sind molekularbiologisch gespeichert. Besonders wichtig sind zudem die Erlebnisse aus der Zeit vor und nach der Geburt. Gesundheit ist ein generationenübergreifendes Projekt. Der Wissenschaftsautor Peter Spork schildert anschaulich und spannend, wie die Weitergabe von Gesundheit und Persönlichkeit funktioniert und wie wir die zugrunde liegenden Prozesse steuern können. Er macht auch klar, wie wir als Eltern und Großeltern unseren Kindern und Enkeln den Weg in ein langes, gesundes und glückliches Leben bereiten können.

Molekulare Biotechnologie

Grundlagen und Anwendungen

Author: David Clark,Nanette Pazdernik

Publisher: Springer-Verlag

ISBN: 3827421896

Category: Science

Page: 707

View: 4308

Grundlage aller biotechnologischen Prozesse sind molekularbiologische und genetische Regelmechanismen. Deshalb behandelt dieses neuartige Lehrbuch beides: die molekularbiologischen Grundlagen und die Anwendungen. Spannend und aktuell werden die Teilgebiete der Biotechnologie und das jeweils erforderliche molekularbiologische Grundwissen beschrieben. Der Bogen wird gespannt von der Nanobiotechnologie über Stoffwechseltechnologie, Genomics und Umweltbiotechnologie bis hin zur Gentherapie.

Epigenetic Principles of Evolution

Author: Nelson R. Cabej

Publisher: Academic Press

ISBN: 0128140682

Category: Science

Page: 852

View: 9854

Epigenetic Principles of Evolution, Second Edition, fully examines the causal basis of evolution from an epigenetic point-of-view. By revealing the epigenetic uses of the genetic toolkit, this work demonstrates the primacy of epigenetic mechanisms and epigenetic information in generating evolutionary novelties. The author convincingly supports his theoretical perspective with examples from varied fields of biology, emphasizing changes in developmental pathways as the basic source of evolutionary change in metazoans. Users will find a broader view of the epigenetic mechanisms of evolution, moving beyond conventional changes in epigenetic structures, such as DNA methylation, histone modifications, and patterns of miRNA, sRNA, and mRNA expression. This second edition is thoroughly updated to reflect new evidence and developing theories in the field of evolutionary epigenetics. New and revised chapters speak to the epigenetic basis of heredity, epigenetic regulation of animal structure and homeostasis, neural manipulation of gene expression, central control of gametogenesis, epigenetic control of early development, the origin of epigenetic information, evolutionary changes in response to environmental stressors, epigenetics of sympatric evolution, and the epigenetics of the Cambrian explosion, among other topics. Adopts an integrative approach to examine the causal basis of evolution from an epigenetic point-of-view Features new and revised chapters which reflect novel experimental and observational evidence in the field of evolutionary epigenetics, as well as alternative theoretical approaches Offers a broad view of epigenetic mechanisms of evolution, moving beyond conventional changes in epigenetic mechanisms, such as DNA methylation, histone modifications, and patterns of miRNA, sRNA and mRNA expression

Epigenetics

Author: C. David Allis

Publisher: CSHL Press

ISBN: 0879697245

Category: Medical

Page: 502

View: 9983

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Handbook of Socialization, Second Edition

Theory and Research

Author: Joan E Grusec, PhD,Paul D. Hastings

Publisher: Guilford Publications

ISBN: 1462525822

Category: Psychology

Page: 718

View: 9101

"Socialization refers to the way in which individuals are assisted in becoming members of one or more social groups, including how the newer members as well as the established ones socialize one another, often in a bi-directional manner, that is, response to socialization impact in both directions. This is the only handbook on socialization that covers the topic from infancy through adulthood. Hot new topics include moral development; the media as a socializing agent; behavior genetics; and, culture. Authors are known in the field"--Résumé de l'éditeur.

Neuropsychiatric Disorders and Epigenetics

Author: Dag Yasui,Jacob Peedicayil,Dennis R. Grayson

Publisher: Academic Press

ISBN: 0128005270

Category: Science

Page: 444

View: 6135

Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease. Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment

Psychopathen

Was man von Heiligen, Anwälten und Serienmördern lernen kann

Author: Kevin Dutton

Publisher: Deutscher Taschenbuch Verlag

ISBN: 3423417781

Category: Psychology

Page: 320

View: 4985

Sind Sie ein Psychopath? Natürlich nicht. Vielleicht sind Sie eine Führungskraft oder ein sehr spiritueller Mensch. Sie haben Charme, Sie sind unerschrocken und risikofreudig, können harte Entscheidungen treffen. Sie sind sehr aufmerksam und können sich gut auf ein Ziel konzentrieren. Sie werden feststellen, dass das Eigenschaften sind, die Sie mit Psychopathen teilen. Selbstredend sind diese Eigenschaften nützlich, wenn man ein Serienmörder werden will. Aber auch im Gerichtssaal, in der Wirtschaft oder im OP. Oder im Leben eines Heiligen. Jede Medaille hat zwei Seiten. »Eine meisterhafte, sehr lesbare und unterhaltsame Darstellung der Psychopathie und ihrer Manifestationen im Alltag. Manche seiner Ideen werden kontrovers diskutiert werden, aber es ist ein höchst anregendes Buch für alle, die die ›psychopathische‹ Welt, in der sie leben, besser verstehen wollen.« Prof. Dr. Robert Hare, Erfinder der Psychopathy Checklist

Die Gene sind es nicht ...

Biologie, Ideologie und menschliche Natur

Author: Richard C. Lewontin,Leon J. Kamin,Steven P. R. Rose

Publisher: N.A

ISBN: 9783621270366

Category:

Page: 264

View: 9926

Der achtsame Therapeut

Ein Leitfaden für die Praxis

Author: Daniel J. Siegel

Publisher: Kösel-Verlag

ISBN: 3641068797

Category: Psychology

Page: 368

View: 8665

Studien belegen, dass die Gegenwärtigkeit und Achtsamkeit des Therapeuten zentral für den Behandlungserfolg sind. Dr. med. Daniel Siegel, Autor des hochgelobten Buches »Das achtsame Gehirn«, eröffnet einen neuartigen Zugang zu therapeutischer Arbeit, der die Art und Weise, wie wir Therapie verstehen, in den kommenden Jahren revolutionieren wird. Wie Therapie Erfolg hat Wichtiges Grundlagenwerk für die therapeutische Praxis Von einem der renommiertesten Gehirnforscher weltweit

Genetik für Dummies

Author: Tara Rodden Robinson

Publisher: John Wiley & Sons

ISBN: 3527811478

Category: Science

Page: 400

View: 1473

Die Genetik ist eine der Naturwissenschaften, deren Wissen am schnellsten wächst und deren Erkenntnisse ständig in Bewegung und in der Diskussion sind. "Genetik für Dummies" erklärt, was überhaupt hinter diesem spannenden Thema steckt. Die Autorin Tara Rodden Robinson erklärt die Grundlagen der Vererbungslehre wie die Mendelschen regeln, wie Zellen aufgebaut sind und sie sich teilen. Sie zeigt, wie die DNA aufgebaut ist, wie sie kopiert und richtig in Proteine übersetzt wird. Außerdem geht sie auf die Bedeutung der Genetik in der Humanmedizin ein, wie Genmutationen und Erbkrankheiten entstehen. Sie erläutert, was beim Klonen passiert und was sich überhaupt hinter dem Begriff Gentechnik verbirgt. Auch die heißen Themen wie Stammzellentherapie und der Einsatz der Genetik in der Rechtsmedizin werden behandelt.

Plant Epigenetics: Methods and Protocols

Author: Igor Kovalchuk

Publisher: Methods in Molecular Biology

ISBN: 9781493979561

Category: Science

Page: 264

View: 7913

This volume provides a variety of protocols to analyze various epigenetic changes, including differential expression of non-coding RNAs, changes in DNA methylation, and histone modifications in plants. Chapters detail protocols with different degrees of complexity, and describe bioinformatics approaches for data processing and analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Plant Epigenetics: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

Spontane Evolution

Wege zum neuen Menschen

Author: Bruce H. Lipton,Steve Bhaerman

Publisher: N.A

ISBN: 9783867281034

Category: USA - Verhalten - Kulturelle Evolution

Page: 508

View: 2629

Klinische Pathophysiologie

Author: Hubert Erich Blum,Dirk Müller-Wieland

Publisher: Georg Thieme Verlag

ISBN: 3131760109

Category: Medical

Page: 1288

View: 466

*** Sichern Sie sich den attraktiven Vorbestellpreis und sparen Sie € 40,- (gültig bis 3 Monate nach Erscheinen – danach € 189,99) *** Gehen Sie den Dingen auf den Grund! Statt Fakten pauken, das Warum verstehen. Das Verständnis der Pathophysiologie ist der Schlüssel zu einer begründeten und präzisen Diagnostik und Therapie. Das Wissen über die Entstehung der verschiedenen Krankheiten sowie über die Bedeutung von Mutationen und Störungen physiologischer Abläufe hat in den vergangenen Jahren massiv zugenommen. Die 10. Auflage des etablierten Standardwerks begründet von Walter Siegenthaler trägt dem Rechnung und schlägt die Brücke zur Klinik. • Pathophysiologie, integriert und fachübergreifend • übersichtliche Kapitelstrukturierung: Physiologische Grundlagen, allgemeine und spezielle Pathophysiologie • didaktische Aufbereitung: Merke-Boxen, Abbildungen, Schemata und Tabellen • interessante Hintergrundinformationen: „The story behind“ Jederzeit zugreifen: Der Inhalt des Buches steht Ihnen ohne weitere Kosten digital in der Wissensplattform eRef zur Verfügung (Zugangscode im Buch). Mit der kostenlosen eRef App haben Sie zahlreiche Inhalte auch offline immer griffbereit.

Gene Control, Second Edition

Author: David Latchman

Publisher: Garland Science

ISBN: 131740775X

Category: Science

Page: 528

View: 1579

The new edition of Gene Control has been updated to include significant advances in the roles of the epigenome and regulatory RNAs in gene regulation. The chapter structure remains the same: the first part consists of pairs of chapters that explain the mechanisms involved and how they regulate gene expression, and the second part deals with specific biological processes (including diseases) and how they are controlled by genes. Coverage of methodology has been strengthened by the inclusion more explanation and diagrams.The significant revision and updating will allow Gene Control to continue to be of value to students, scientists and clinicians interested in the topic of gene control.

Tumor Board Review, Second Edition

Guideline and Case Reviews in Oncology

Author: Francis P. Worden, MD

Publisher: Demos Medical Publishing

ISBN: 161705223X

Category: Medical

Page: 136

View: 2646

Praise for the First Edition “As everyone in oncology fellowship training knows, there is a huge [information] gap in this field. Most oncology books are massive and loaded with information…by the time the book is [published]…it is outdated.” [Tumor Board Review] is fresh and just out of the oven…I haven’t seen any book in oncology like this so far…I think my investment in this book was wise and worth it.” — Humaid Al-Shamsi, MB(Hon), BMedSc, MRCP(UK), FRCP, FACP, Assistant Professor, The University of Texas, MD Anderson Cancer Center Culling the knowledge and expertise of respected oncology specialists, this is a concise yet comprehensive review of all areas of oncology practice for medical oncologists, radiation oncologists, and pathologists — both students and practitioners. The second edition of Tumor Board Review has been thoroughly revised to encompass recent scientific advances in assessment and treatment, new clinical guidelines, and new FDA-approved drugs and indications. It also contains approximately 250 multiple-choice questions and answers to assist readers in testing their knowledge, especially those preparing for the MOC exam. The book features case presentations and evidence-based management discussions that clearly demonstrate how to apply new information in daily practice. In a consistent format, each chapter addresses epidemiology, risk factors, natural history, and pathology of each major organ-specific tumor type; an abbreviated display of relevant staging; and several “tumor board style” illustrative patient case studies. This is followed by an evidence-based case discussion, which reinforces current guidelines and explains the rationale for the diagnostic and therapeutic steps taken. Algorithms and decision-tree graphics further illuminate the decision process. NEW TO THE SECOND EDITION OF TUMOR BOARD REVIEW: Presents the most recent guidelines and management standards in user-friendly format Focuses on current indications, use of new drugs, and new treatment of side effects Includes new FDA-approved drugs and guidelines Offers approximately 250 multiple-choice questions and answers

The Developing Mind, Second Edition

How Relationships and the Brain Interact to Shape Who We Are

Author: Daniel J. Siegel

Publisher: Guilford Press

ISBN: 1462503926

Category: Psychology

Page: 506

View: 4526

This bestselling book put the field of interpersonal neurobiology on the map for over 100,000 readers. Daniel J. Siegel goes beyond the nature and nurture divisions that traditionally have constrained much of our thinking about development, exploring the role of interpersonal relationships in forging key connections in the brain. He presents a groundbreaking new way of thinking about the emergence of the human mind and the process by which each of us becomes a feeling, thinking, remembering individual. Illuminating how and why neurobiology matters, this book is essential reading for clinicians, educators, researchers, and students interested in promoting healthy development and resilience. Professors praise the book’s utility in courses from developmental psychology and child development to neuroscience and counseling. New to This Edition *Incorporates significant scientific and technical advances. *Expanded discussions of cutting-edge topics, including neuroplasticity, epigenetics, mindfulness, and the neural correlates of consciousness. *Useful pedagogical features: pull-outs, diagrams, and a glossary. *Epilogue on domains of integration--specific pathways to well-being and therapeutic change.