This volume, representing a compilation of authoritative reviews on a multitude of uses of statistics in epidemiology and medical statistics written by internationally renowned experts, is addressed to statisticians working in biomedical and epidemiological fields who use statistical and quantitative methods in their work. While the use of statistics in these fields has a long and rich history, explosive growth of science in general and clinical and epidemiological sciences in particular have gone through a see of change, spawning the development of new methods and innovative adaptations of standard methods. Since the literature is highly scattered, the Editors have undertaken this humble exercise to document a representative collection of topics of broad interest to diverse users. The volume spans a cross section of standard topics oriented toward users in the current evolving field, as well as special topics in much need which have more recent origins. This volume was prepared especially keeping the applied statisticians in mind, emphasizing applications-oriented methods and techniques, including references to appropriate software when relevant. · Contributors are internationally renowned experts in their respective areas · Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research · Methods for assessing Biomarkers, analysis of competing risks · Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs · Structural equations modelling and longitudinal data analysis
This straightforward primer in basic statistics emphasizes its practical use in epidemiology and public health, providing understanding of essential topics such as study design, data analysis and statistical methods used in the execution of medical research. This new edition is substantially revised and includes entirely new material on statistical power and sample size. Clearly worded and assuming no prior knowledge, it gives full step-by-step guidance on performing statistical calculations. It contains numerous examples and exercises with detailed answers to help readers grasp the main points of these complex subjects with ease, providing doctors, nurses, health managers, researchers and students with a concise and practical guide
While biomedical researchers may be able to follow instructions in the manuals accompanying the statistical software packages, they do not always have sufficient knowledge to choose the appropriate statistical methods and correctly interpret their results. Statistical Thinking in Epidemiology examines common methodological and statistical problems in the use of correlation and regression in medical and epidemiological research: mathematical coupling, regression to the mean, collinearity, the reversal paradox, and statistical interaction. Statistical Thinking in Epidemiology is about thinking statistically when looking at problems in epidemiology. The authors focus on several methods and look at them in detail: specific examples in epidemiology illustrate how different model specifications can imply different causal relationships amongst variables, and model interpretation is undertaken with appropriate consideration of the context of implicit or explicit causal relationships. This book is intended for applied statisticians and epidemiologists, but can also be very useful for clinical and applied health researchers who want to have a better understanding of statistical thinking. Throughout the book, statistical software packages R and Stata are used for general statistical modeling, and Amos and Mplus are used for structural equation modeling.
There has been a growing recognition of the importance of mathematical and statistical methods in the history of medicine, particularly in those areas where statistical methods are a sine qua non such as epidemiology and randomised clinical trials. Despite this expanding scholarly interest, the development of the mathematical and statistical technologies in the biological sciences has not been examined systematically. This collection of essays aims to provide a broader overview of this field, and to explore the use of these with the use of these quantitative technologies in medical and clinical cultures from the seventeenth to the twentieth centuries.
The book aims to provide both comprehensive reviews of the classical methods and an introduction to new developments in medical statistics. The topics range from meta analysis, clinical trial design, causal inference, personalized medicine to machine learning and next generation sequence analysis. Since the publication of the first edition, there have been tremendous advances in biostatistics and bioinformatics. The new edition tries to cover as many important emerging areas and reflect as much progress as possible. Many distinguished scholars, who greatly advanced their research areas in statistical methodology as well as practical applications, also have revised several chapters with relevant updates and written new ones from scratch. The new edition has been divided into four sections, including, Statistical Methods in Medicine and Epidemiology, Statistical Methods in Clinical Trials, Statistical Genetics, and General Methods. To reflect the rise of modern statistical genetics as one of the most fertile research areas since the publication of the first edition, the brand new section on Statistical Genetics includes entirely new chapters reflecting the state of the art in the field. Although tightly related, all the book chapters are self-contained and can be read independently. The book chapters intend to provide a convenient launch pad for readers interested in learning a specific topic, applying the related statistical methods in their scientific research and seeking the newest references for in-depth research. Contents:Statistics in Medicine and Epidemiology:History of Statistical Thinking in Medicine (Tar Timothy Chen)Describing Data, Modeling Variation, and Statistical Practice (Hongyan Du and Ming T Tan)Covariate-Specific and Covariate-Adjusted Predictive Values of Prognostic Biomarkers with Survival Outcome (Yunbei Ma, Xiao-Hua Zhou and Kwun Chuen (Gary) Chan)Statistical Methods for Personalized Medicine (Lu Tian and Xiaoguang Zhao)Statistics Used in Quality Control, Quality Assurance, and Quality Improvement in Radiological Studies (Ying Lu and Shoujun Zhao)Applications of Statistical Methods in Medical Imaging (Jesse S Jin)Cost-Effectiveness Analysis and Evidence-Based Medicine (Jianli Li)Quality of Life: Issues Concerning Assessment and Analysis (Jiqian Fang and Yuantao Hao)Meta-Analysis (Xuyu Zhou, Jiqian Fang, Chuanhua Yu, Zongli Xu, Lu Tian, and Ying Lu)Statistical Models and Methods in Infectious Diseases (Hulin Wu and Shoujun Zhao)Special Models for Sampling Survey (Sujuan Gao)The Use of Capture–Recapture Methodology in Epidemiological Surveillance and Ecological Surveys (Anne Chao, T C Hsieh and Hsin-Chou Yang)Statistical Methods in the Effective Evaluation of Mass Screening for Diseases (Qing Liu)Statistics in Clinical Trials:Statistics in Biopharmaceutical Research and Development (Shein-Chung Chow and Annpey Pong)Statistics in Pharmacology and Pre-Clinical Studies (Tze Leung Lai, Mei-Chiung Shin and Guangrui Zhu)Statistics in Toxicology (James J Chen)Dose-Response Modeling and Benchmark Doses in Health Risk Assessment (Yiliang Zhu)Some Fundamental Statistical Issues and Methodologies in Confirmatory Trials (George Y H Chi, Haiyan Xu and Qing Liu)Surrogates for Qualitative Evaluation of Treatment Effects (Zhi Geng)Adaptive Trial Design in Clinical Research (Annpey Pong and Shein-Chung Chow)Statistics in the Research of Traditional Chinese Medicine (Danhui Yi and Yang Li)Statistical Genetics:Sparse Segment Identifications with Applications to DNA Copy Number Variation Analysis (X Jessie Jeng, T Tony Cai and Hongzhe Li)Statistical Methods for Design and Analysis of Linkage Studies (Qizhai Li, Hong Qin, Zhaohai Li, and Gang Zheng)Transcriptome Analysis Using Next-Generation Sequencing (Jingyi Jessica Li, Haiyan Huang, Minping Qian and Xuegong Zhang)Genetic Structure of Human Population (Hua Tang and Kun Tang)Data Integration Methods in Genome Wide Association Studies (Ning Sun and Hongyu Zhao)Causal Inference (Zhi Geng)General Methods:Survival Analysis (D Y Lin)Nonparametric Regression Models for the Analysis of Longitudinal Data (Colin O Wu, Xin Tian, Kai F Yu, and Mi-Xia Wu)Local Modeling: Density Estimation and Nonparametric Regression (Jianqing Fan and Runze Li)Statistical Methods for Dependent Data (Feng Chen)Bayesian Methods (Ming-Hui Chen and Keying Ye)Valid Prior-Free Probabilistic Inference and Its Applications in Medical Statistics (Duncan Ermini Leaf, Hyokun Yun, and Chuanhai Liu)Stochastic Processes and Their Applications in Medical Science (Caixia Li and Jiqian Fang)Interpolation of Missing Values and Adjustment of Moving Holiday Effect in Time Series (Zhang Jin-Xin, Zhang Xi, Xue Yun-Lian, Li Ji-Bin and Huang Bo)Tree-based Methods (Heping Zhang)Introduction to Artificial Neural Networks (Xia Jielai, Jiang Hongwei, and Tang Qiyi) Readership: Biostatisticians, applied statisticians, medical researchers and clinicians, biopharmaceutical researchers, public health epidemiologists, biometricians and applied mathematicians. Key Features: The book covers very broad topics in medical statistics The book covers both most recent developments as well as classical work of the selected areas The book chapter is written by the experts in the field and illustrated with real life examplesKeywords:Medicine;Statistics;Epidemiology;Genomics;Clinical Trials;Bioinformatics;Machine Learning;Statistical Theory;Public HealthReviews: Review of the First Edition: “Overall the book covers a wide variety of applications. Each method is presented in sufficient depth to allow the reader to understand when the method(s) can be used … this book would be a useful resource for any practitioner in medical research.” Statistical Methods in Medical Research
Essential Statistical Methods for Medical Statistics presents only key contributions which have been selected from the volume in the Handbook of Statistics: Medical Statistics, Volume 27 (2009). While the use of statistics in these fields has a long and rich history, the explosive growth of science in general, and of clinical and epidemiological sciences in particular, has led to the development of new methods and innovative adaptations of standard methods. This volume is appropriately focused for individuals working in these fields. Contributors are internationally renowned experts in their respective areas. · Contributors are internationally renowned experts in their respective areas · Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research · Methods for assessing Biomarkers, analysis of competing risks · Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs · Structural equations modelling and longitudinal data analysis
Anyone who attempts to read genetics or epidemiology research literature needs to understand the essentials of biostatistics. This book, a revised new edition of the successful Essentials of Biostatistics has been written to provide such an understanding to those who have little or no statistical background and who need to keep abreast of new findings in this fast moving field. Unlike many other elementary books on biostatistics, the main focus of this book is to explain basic concepts needed to understand statistical procedures. This Book: Surveys basic statistical methods used in the genetics and epidemiology literature, including maximum likelihood and least squares. Introduces methods, such as permutation testing and bootstrapping, that are becoming more widely used in both genetic and epidemiological research. Is illustrated throughout with simple examples to clarify the statistical methodology. Explains Bayes’ theorem pictorially. Features exercises, with answers to alternate questions, enabling use as a course text. Written at an elementary mathematical level so that readers with high school mathematics will find the content accessible. Graduate students studying genetic epidemiology, researchers and practitioners from genetics, epidemiology, biology, medical research and statistics will find this an invaluable introduction to statistics.
Since the publication of the first edition, Biostatistics and Epidemiology has attracted loyal readers from across specialty areas in the biomedical community. Not only does this textbook teach foundations of epidemiological design and statistical methods, but it also includes topics applicable to new areas of research. Areas covered in the fourth edition include a new chapter on risk prediction, risk reclassification and evaluation of biomarkers, new material on propensity analyses, and a vastly expanded chapter on genetic epidemiology, which is particularly relevant to those who wish to understand the epidemiological and statistical aspects of scientific articles in this rapidly advancing field. Biostatistics and Epidemiology was written to be accessible for readers without backgrounds in mathematics. It provides clear explanations of underlying principles, as well as practical guidelines of "how to do it" and "how to interpret it." Key features include a philosophical and logical explanation at the beginning of the book, subsections that can stand alone or serve as reference, cross-referencing, recommended reading, and appendices covering sample calculations for various statistics in the text.
Epidemiologic studies provide research strategies for investigating public health and scientific questions relating to the factors that cause and prevent ailments in human populations. Statistics in Epidemiology: Methods, Techniques and Applications presents a comprehensive review of the wide range of principles, methods and techniques underlying prospective, retrospective and cross-sectional approaches to epidemiologic studies. Written for epidemiologists and other researchers without extensive backgrounds in statistics, this new book provides a clear and concise description of the statistical tools used in epidemiology. Emphasis is given to the application of these statistical tools, and examples are provided to illustrate direct methods for applying common statistical techniques in order to obtain solutions to problems. Statistics in Epidemiology: Methods, Techniques and Applications goes beyond the elementary material found in basic epidemiology and biostatistics books and provides a detailed account of techniques:
Translating the evidence from the bedside topopulations This sixth edition of the best-selling Epidemiology,Evidence-based Medicine and Public Health Lecture Notes equipsstudents and health professionals with the basic tools required tolearn, practice and teach epidemiology and health prevention in acontemporary setting. The first section, ‘Epidemiology’, introduces thefundamental principles and scientific basis behind work to improvethe health of populations, including a new chapter on geneticepidemiology. Applying the current and best scientific evidence totreatment at both individual and population level is intrinsicallylinked to epidemiology and public health, and has been introducedin a brand new second section: ‘Evidence-basedMedicine’ (EBM), with advice on how to incorporate EBMprinciples into your own practice. The third section, 'PublicHealth', introduces students to public health practice, includingstrategies and tools used to prevent disease, prolong life, reduceinequalities, and includes global health. Thoroughly updated throughout, including new studies and casesfrom around the globe, key learning features include: Learning objectives and key points in every chapter Extended coverage of critical appraisal and datainterpretation A brand new self-assessment section of SAQs and’True/False’ questions for each topic A glossary to quickly identify the meaning of key terms, all ofwhich are highlighted for study and exam preparation Further reading suggestions on each topic Whether approaching these topics for the first time, starting aspecial study module or placement, or looking for a quick-referencesummary, this book offers medical students, junior doctors, andpublic health students an invaluable collection of theoretical andpractical information.
This IMA Volume in Mathematics and its Applications STATISTICAL MODELS IN EPIDEMIOLOGY, THE ENVIRONMENT,AND CLINICAL TRIALS is a combined proceedings on "Design and Analysis of Clinical Trials" and "Statistics and Epidemiology: Environment and Health. " This volume is the third series based on the proceedings of a very successful 1997 IMA Summer Program on "Statistics in the Health Sciences. " I would like to thank the organizers: M. Elizabeth Halloran of Emory University (Biostatistics) and Donald A. Berry of Duke University (Insti tute of Statistics and Decision Sciences and Cancer Center Biostatistics) for their excellent work as organizers of the meeting and for editing the proceedings. I am grateful to Seymour Geisser of University of Minnesota (Statistics), Patricia Grambsch, University of Minnesota (Biostatistics); Joel Greenhouse, Carnegie Mellon University (Statistics); Nicholas Lange, Harvard Medical School (Brain Imaging Center, McLean Hospital); Barry Margolin, University of North Carolina-Chapel Hill (Biostatistics); Sandy Weisberg, University of Minnesota (Statistics); Scott Zeger, Johns Hop kins University (Biostatistics); and Marvin Zelen, Harvard School of Public Health (Biostatistics) for organizing the six weeks summer program. I also take this opportunity to thank the National Science Foundation (NSF) and the Army Research Office (ARO), whose financial support made the workshop possible. Willard Miller, Jr.
Wie die Spanische Grippe die Gesellschaft veränderte
Author: Laura Spinney
Publisher: Carl Hanser Verlag GmbH Co KG
Der Erste Weltkrieg geht zu Ende, und eine weitere Katastrophe fordert viele Millionen Tote: die Spanische Grippe. Binnen weniger Wochen erkrankt ein Drittel der Weltbevölkerung. Trotzdem sind die Auswirkungen auf Gesellschaft, Politik und Kultur weitgehend unbekannt. Ob in Europa, Asien oder Afrika, an vielen Orten brachte die Grippe die Machtverhältnisse ins Wanken, womöglich beeinflusste sie die Verhandlung des Versailler Vertrags und verursachte Modernisierungsbewegungen. Anhand von Schicksalen auf der ganzen Welt öffnet Laura Spinney das Panorama dieser Epoche. Sie füllt eine klaffende Lücke in der Geschichtsschreibung und erlaubt einen völlig neuen Blick auf das Schicksalsjahr 1918.
This book contains a Foreword by Allyson Pollock, Professor and Head, Centre for International Public Health Policy, University of Edinburgh. Healthcare students, practitioners and researchers need a sound basis for making valid statistical inferences from health data. To make the best use of statistical software, it is necessary to understand how probabilistic inference works. This book explains that, along with the various ways statistical data can be described and presented. It is designed to develop insight rather than simply the mechanical skills found in other textbooks. This book is specifically designed to underpin the concepts of statistics and epidemiology. It is practical and easy to use and is ideal for people who can feel uncomfortable with mathematics. 'Excellent. A great primer for all students and research workers engaged in learning how to use statistical ideas in public health. It sets out the core concepts and explains them clearly, using worked examples as illustration. If followed carefully, the engaged reader should be able to use the standard statistical software packages intelligently and sensitively. It will stimulate the public health student, in whatever context, and new researchers, to approach the enterprise with enhanced confidence in interpreting and coherently explaining their findings.' - Allyson Pollock, in the Foreword.
James F. Jekel,David L. Katz,Joann G. Elmore,Dorothea Wild
Author: James F. Jekel,David L. Katz,Joann G. Elmore,Dorothea Wild
Publisher: Elsevier Health Sciences
Succinct yet thorough, Epidemiology, Biostatistics, and Preventive Medicine, 3rd Edition brings you today's best knowledge on epidemiology, biostatistics, preventive medicine, and public health-in one convenient source. You'll find the latest on healthcare policy and financing · infectious diseases · chronic disease · and disease prevention technology. This text also serves as an outstanding resource for preparing for the USMLE, and the American Board of Preventive Medicine recommends it as a top review source for its core specialty examination. Discusses the financial concerns and the use and limitations of screening in the prevention of symptomatic disease. Emphasizes the application of epidemiologic and biostatistical concepts to everyday clinical problem solving and decision making. Showcases important concepts and calculations inside quick-reference boxes. Presents abundant illustrations and well-organized tables to clarify and summarize complex concepts. Includes 350 USMLE-style questions and answers, complete with detailed explanations about why various choices are correct or incorrect. Includes the latest information on Bovine Spongiform Encephalopathy (BSE) · SARS · avian form of H5N1 influenza · the obesity epidemic · and more.
Medical Statistics at a Glance is a concise and accessible introduction and revision aid for this complex subject. The self-contained chapters explain the underlying concepts of medical statistics and provide a guide to the most commonly used statistical procedures. This new edition of Medical Statistics at a Glance: Presents key facts accompanied by clear and informative tables and diagrams Focuses on illustrative examples which show statistics in action, with an emphasis on the interpretation of computer data analysis rather than complex hand calculations Includes extensive cross-referencing, a comprehensive glossary of terms and flow-charts to make it easier to choose appropriate tests Now provides the learning objectives for each chapter Includes a new chapter on Developing Prognostic Scores Includes new or expanded material on study management, multi-centre studies, sequential trials, bias and different methods to remove confounding in observational studies, multiple comparisons, ROC curves and checking assumptions in a logistic regression analysis The companion website at www.medstatsaag.com contains supplementary material including an extensive reference list and multiple choice questions (MCQs) with interactive answers for self-assessment. Medical Statistics at a Glance will appeal to all medical students, junior doctors and researchers in biomedical and pharmaceutical disciplines. Reviews of the previous editions "The more familiar I have become with this book, the more I appreciate the clear presentation and unthreatening prose. It is now a valuable companion to my formal statistics course." –International Journal of Epidemiology "I heartily recommend it, especially to first years, but it's equally appropriate for an intercalated BSc or Postgraduate research. If statistics give you headaches - buy it. If statistics are all you think about - buy it." –GKT Gazette "...I unreservedly recommend this book to all medical students, especially those that dislike reading reams of text. This is one book that will not sit on your shelf collecting dust once you have graduated and will also function as a reference book." –4th Year Medical Student, Barts and the London Chronicle, Spring 2003
Lecture Notes: Epidemiology and Public Health Medicine new edition, is a core text that covers the basics of epidemiology - preventive medicine - public health - the organisation of medical care. The book is divided into three parts: Part 1 Written to provide background and detailed information on epidemiology and public health medicine. Casue and risk factors are discussed along with examples of theory and practice. The different types of epidemiological study design, sources of information and demographical data and studies are included. Part 2 Evidence-based medicine is covered along with general principles on epidemiology. Promoting and educating on the control and immunisation procedures are dicsussed, with empahsis on environmental health and preventative methods and screening are topics highlighted. Part 3 Historical cases and principles are reviewed. The effects on epidemiology and public health is dicussed in relation to the National Health Service, and targets and evaluation procedures are covered. Lecture Notes: Epidemiology and Public Health Medicine is aimed at setting the basic medical science into a global and clinical setting. The book will appeal to all medical students and practising doctors who want to make clinical decisions based on sound evidence. Public health Nurses may also find this book as a useful resource too. Review quotations from the previous edition: "makes the best job possible of explaining the seemingly impenetrable jungle of epidemiology" Scope Magazine