Coalescent Theory

An Introduction

Author: John Wakeley

Publisher: Roberts Publishers

ISBN: 9780974707754

Category: Medical

Page: 326

View: 9437

"An introduction to coalescent theory, which provides the foundation for molecular population genetics and genomics. Coalescent theory is the conceptual framework for studies of DNA sequence variation within species, and is the source of essential tools for making inferences about mutation, recombination, population structure and natural selection from DNA sequence data"--Provided by publisher.

Gene Genealogies, Variation and Evolution: A primer in coalescent theory

Author: Jotun Hein,Mikkel Schierup,Carsten Wiuf

Publisher: Oxford University Press, USA

ISBN: 9780191546150


Page: 296

View: 6345

Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. - Professor Montgomery Slatkin (Berkeley);the authors are outstanding experts in the field, and the book is topical and timely. - Professor David Balding (Imperial College);Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. - Professor Joe Felsenstein (University of Washington)

Theories of Population Variation in Genes and Genomes

Author: Freddy Bugge Christiansen

Publisher: Princeton University Press

ISBN: 1400866650

Category: Science

Page: 432

View: 5357

This textbook provides an authoritative introduction to both classical and coalescent approaches to population genetics. Written for graduate students and advanced undergraduates by one of the world's leading authorities in the field, the book focuses on the theoretical background of population genetics, while emphasizing the close interplay between theory and empiricism. Traditional topics such as genetic and phenotypic variation, mutation, migration, and linkage are covered and advanced by contemporary coalescent theory, which describes the genealogy of genes in a population, ultimately connecting them to a single common ancestor. Effects of selection, particularly genomic effects, are discussed with reference to molecular genetic variation. The book is designed for students of population genetics, bioinformatics, evolutionary biology, molecular evolution, and theoretical biology--as well as biologists, molecular biologists, breeders, biomathematicians, and biostatisticians. Contains up-to-date treatment of key areas in classical and modern theoretical population genetics Provides in-depth coverage of coalescent theory Discusses genomic effects of selection Gives examples from empirical population genetics Incorporates figures, diagrams, and boxed features throughout Includes end-of-chapter exercises Speaks to a wide range of students in biology, bioinformatics, and biostatistics


Author: Stephen Baxter

Publisher: Random House Digital, Inc.

ISBN: 0345457862

Category: Fiction

Page: 527

View: 2751

Discovering he has a twin sister after the death of his father, George Poole learns his sister has been raised by an enigmatic religious group that is promoting a questionable agenda beneath the streets of Rome.

Statistics in Genetics

Author: M.Elizabeth Halloran,Seymour Geisser

Publisher: Springer Science & Business Media

ISBN: 9780387988283

Category: Medical

Page: 238

View: 905

Though the Genome Project will eventually result in the sequencing of the human genome, as well as the genomes of several other organisms, there will still be a need for good statistics for family studies of complex diseases. The papers in this volume are contributions by some of the leading researchers in the field to the current topics in statistical genetics. One section deals with DNA sequence matching and issues related to forensics, while another deals with statistical problems of modeling phylogenies and inferential difficulties related to the complex tree structures produced, as well as the method of coalescence.

Mathematical Population Genetics 1

Theoretical Introduction

Author: Warren J. Ewens

Publisher: Springer Science & Business Media

ISBN: 038721822X

Category: Science

Page: 418

View: 6214

This is the first of a planned two-volume work discussing the mathematical aspects of population genetics with an emphasis on evolutionary theory. This volume draws heavily from the author’s 1979 classic, but it has been revised and expanded to include recent topics which follow naturally from the treatment in the earlier edition, such as the theory of molecular population genetics.

An Introduction to Population Genetics

Theory and Applications

Author: Rasmus Nielsen,Montgomery Slatkin

Publisher: Sinauer Associates Incorporated

ISBN: 9781605351537

Category: Science

Page: 287

View: 9671

"A text for a one-semester course in population genetics. It introduces students to classical population genetics (in terms of allele and haplotype frequencies) and modern population genetics (in terms of coalescent theory). It presents numerous applications of population genetic methods to practical problems, including testing for natural selection, detecting genetic hitchhiking and inferring the history of populations"--Provided by publisher.

Handbook of Statistical Genetics

Author: David J. Balding,Martin Bishop,Chris Cannings

Publisher: John Wiley & Sons

ISBN: 9780470997628

Category: Science

Page: 1616

View: 5694

The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.

Molecular Evolution

A Statistical Approach

Author: Ziheng Yang

Publisher: Oxford University Press

ISBN: 0199602603

Category: Science

Page: 492

View: 7171

"Studies of evolution at the molecular level have experienced phenomenal growth in the last few decades, due to rapid accumulation of genetic sequence data, improved computer hardware and software, and the development of sophisticated analytical methods. The flood of genomic data has generated an acute need for powerful statistical methods and efficient computational algorithms to enable their effective analysis and interpretation. This advanced textbook is aimed at graduate level students and professional researchers (both empiricists and theoreticians) in the fields of bioinformatics and computational biology, statistical genomics, evolutionary biology, molecular systematics, and population genetics. It will also be of relevance and use to a wider audience of applied statisticians, mathematicians, and computer scientists working in computational biology."--back cover.

Population Genetics and Microevolutionary Theory

Author: Alan R. Templeton

Publisher: John Wiley & Sons

ISBN: 0470047216

Category: Science

Page: 720

View: 4859

The advances made possible by the development of molecular techniques have in recent years revolutionized quantitative genetics and its relevance for population genetics. Population Genetics and Microevolutionary Theory takes a modern approach to population genetics, incorporating modern molecular biology, species-level evolutionary biology, and a thorough acknowledgment of quantitative genetics as the theoretical basis for population genetics. Logically organized into three main sections on population structure and history, genotype-phenotype interactions, and selection/adaptation Extensive use of real examples to illustrate concepts Written in a clear and accessible manner and devoid of complex mathematical equations Includes the author's introduction to background material as well as a conclusion for a handy overview of the field and its modern applications Each chapter ends with a set of review questions and answers Offers helpful general references and Internet links

Advances in Molecular Ecology

Author: North Atlantic Treaty Organization. Scientific Affairs Division

Publisher: IOS Press

ISBN: 9789051994407

Category: Science

Page: 313

View: 6187

Each contributor to this publication was asked to examine how molecular genetic tools have contributed to their specific areas of consideration. To increase the practical utility of the book, a summary of software that is available for the anaylsis of data in molecular ecology is included.

The Nature of Classification

Relationships and Kinds in the Natural Sciences

Author: J. Wilkins,M. Ebach

Publisher: Springer

ISBN: 1137318120

Category: Science

Page: 197

View: 9043

Discussing the generally ignored issue of the classification of natural objects in the philosophy of science, this book focuses on knowledge and social relations, and offers a way to understand classification as a necessary aspect of doing science.


The History and Formation of Species

Author: John C. Avise

Publisher: Harvard University Press

ISBN: 9780674666382

Category: Science

Page: 447

View: 3900

Phylogeography is a discipline concerned with various relationships between gene genealogies--phylogenetics--and geography. The word "phylogeography" was coined in 1987, and since then the scientific literature has reflected an exploding interest in the topic. Yet, to date, no book-length treatment of this emerging field has appeared. "Phylogeography" fills that gap. It captures the conceptual and empirical richness of the field, and also the sense of genuine innovation that phylogeographic perspectives have brought to evolutionary studies.

Handbook on Analyzing Human Genetic Data

Computational Approaches and Software

Author: Shili Lin,Hongyu Zhao

Publisher: Springer Science & Business Media

ISBN: 3540692649

Category: Medical

Page: 333

View: 7628

This handbook offers guidance on selections of appropriate computational methods and software packages for specific genetic problems. Coverage strikes a balance between methodological expositions and practical guidelines for software selections. Wherever possible, comparisons among competing methods and software are made to highlight the relative advantages and disadvantage of the approaches.

Genetic Structure and Selection in Subdivided Populations (MPB-40)

Author: François Rousset

Publisher: Princeton University Press

ISBN: 1400847249

Category: Science

Page: 288

View: 3199

Various approaches have been developed to evaluate the consequences of spatial structure on evolution in subdivided populations. This book is both a review and new synthesis of several of these approaches, based on the theory of spatial genetic structure. François Rousset examines Sewall Wright's methods of analysis based on F-statistics, effective size, and diffusion approximation; coalescent arguments; William Hamilton's inclusive fitness theory; and approaches rooted in game theory and adaptive dynamics. Setting these in a framework that reveals their common features, he demonstrates how efficient tools developed within one approach can be applied to the others. Rousset not only revisits classical models but also presents new analyses of more recent topics, such as effective size in metapopulations. The book, most of which does not require fluency in advanced mathematics, includes a self-contained exposition of less easily accessible results. It is intended for advanced graduate students and researchers in evolutionary ecology and population genetics, and will also interest applied mathematicians working in probability theory as well as statisticians.

Probability Models for DNA Sequence Evolution

Author: Richard Durrett

Publisher: Springer Science & Business Media

ISBN: 9780387781693

Category: Mathematics

Page: 431

View: 4360

"What underlying forces are responsible for the observed patterns of variability, given a collection of DNA sequences?" In approaching this question a number of probability models are introduced and anyalyzed.Throughout the book, the theory is developed in close connection with data from more than 60 experimental studies that illustrate the use of these results.

Human Population Genetics

Author: John H. Relethford

Publisher: John Wiley & Sons

ISBN: 0470464674

Category: Science

Page: 296

View: 8641

"Human Population Genetics will provide an introduction to mathematical population genetics, along with relevant examples from human (and some non-human primate) populations, and will also present concepts and methods of population genetics that are specific to the study of human populations. The purpose of this book is to provide a basic background text for advanced undergraduate and graduate students interesting in the mechanisms of human microevolution"--

Principles of Population Genetics

Author: Daniel L. Hartl,Andrew G. Clark

Publisher: Sinauer Associates Incorporated

ISBN: 9780878933082

Category: Science

Page: 652

View: 5615

This edition provides a balanced presentation of theory and observation. It introduces the principles of genetics and statistics that are relevant to population studies, and examines the forces affecting genetic variation from the molecular to the organismic level.