Biosensoren vereinigen so inkompatible Welten wie Molekularbiologie und Elektronik. Das Potential für Anwendungen von Biosensoren ist enorm hoch und reicht von der Messung der Ölverschmutzung unserer Weltmeere bis zur Bestimmung des Glucosespiegels im Blut. Das vorliegende Buch gibt zunächst eine Einführung in die Molekularbiologie und Biochemie, soweit dies zum Verständnis der Biosensor-Technologie notwendig ist. Es werden dann die verschiedensten Biosensor-Typen sowie deren wissenschaftliche und kommerzielle Anwendungen beschrieben.
Biosensors combine the unique properties of biological systems to selectively recognize and convert molecules with the benefits of physicochemical sensor technology, such as high sensitivity, simplicity of operation and mass production, and modern electronics. Consequently, their development is closely related to progress in two branches of high technology - biotechnology and microelectronics. This book not only presents the state-of-the-art of biosensor research and development to the specialist, but also introduces the layman to the fundamentals of the subject. The relevant features of physicochemical transducer elements as well as biochemical recognition molecules (enzymes, antibodies, receptors) are outlined. Biochemical and biotechnological aspects of biomolecule immobilization and the interplay of biochemical reactions and mass transfer processes are comprehensively treated with regard to their impact on successful sensor design. Examples of immobilization methods are described in detail. The employment of coupled enzyme reactions, higher integrated biocatalytic systems (cell organelles, microbes, tissue sections) and immunocomponents in biosensors is covered extensively. Optical, thermometric, piezoelectric and particularly electrochemical biosensors for more than 100 analytes are presented, including immunosensors. The relative merits and limits of biosensors are discussed using several examples of their application in clinical chemistry, bioprocess control and environmental monitoring. Finally, the application of biosensors in medicine, biotechnology, food industry and environmental control is discussed, including commercialization and problems to be addressed in future research.
There is a worldwide effort towards the development of bioanalytical devices that can be used for detection, quantification and monitoring of specific chemical species. In this context, biosensors represent an emerging trend in the diagnostics industry. A biosensor is a device that has a biological sensing element either intimately connected to or integrated within a transducer. The aim is to produce a digital electronic signal that is proportional to the concentration of a specific chemical or a set of chemicals. Biosensors are specific, rapid, cost-effective and easy to use devices that can be employed with minimal sample treatment. Biosensors have applications in many areas such as biotechnology, healthcare, pollution monitoring, food and agriculture product monitoring, the pharmaceuticals industry and defense. This reference text is devoted to the principles and applications of biosensors and meets the needs of academic institutes, research laboratories and the rapidly developing biosensor industry. Discusses novel ways that can be used to fabricate biosensors for a variety of applications Biosensors have applications in many scientific areas Contributors are experts in their respective fields of research
This introductory text covers in detail the technology and applications of biosensors in their many forms. It provides an extensive survey of the basic principles, functions and applications of different categories of biosensors. The presentation is concise, systematic and well illustrated. Numerous schematics illustrate design and function. This book is an overview of the basic theories of operation for a number of specific types of biosensor transducers that have been investigated, with a general survey of some of the many applications using various biological elements that have been tested to date. A major portion of this book has been devoted to electrochemical transducers, since they have been most widely used. This bestselling text provides basic information for all those involved in the research, development, and applications of biosensors.
A biosensor is a device for the detection of an analyte that combines a biological component with a physiochemical detector component. A typical biosensor consists of three parts: a sensitive biological element, a transducer in between and a detector element. The most widespread example of a commercial biosensor is the blood glucose biosensor, which uses an enzyme to break blood glucose down. In so doing it transfers an electron to an electrode and this is converted into a measure of blood glucose concentration. The high market demand for such sensors has fuelled development of associated sensor technologies. This book covers recent developments that combine the fields of biotechnology and electrical engineering with applications in the detection of very low levels of chemicals and biological agents in the body. It provides an authentic overview of a wide range of biosensing systems, discussing the elements of different transducers used in sensors and the selective elements that are employed. The style is relatively non-mathematical and informal in approach. The contents of the book will be ideal for graduate and postgraduate students of biotechnology, analytical and physical chemistry. It will also be invaluable to all those concerned with the environmental and biomedical applications of such biosensing systems.
This book describes the design, construction, optimization and applications of biosensors, including the biological component, its attachment to the transducer, and interfacing of the sensing element to appropriate electronic circuitry. In addition, typical applications of the sensor are described, along with any specimen pretreatment that may be necessary to remove interferences or ensure linearity of the sensor's response. A final chapter on the theoretical analysis of biosensor response characteristics is provided to aid in optimizing any device's performance. Biosensors provides an up-to-date account of techniques which today are being widely used by life scientists in universities and industry.
Biosensors have captured the imagination of the world's scientific and commercial communities by combining interdisciplinary skills of biologists, physicists, chemists and engineers to provide innovative solutions to analytical problems. Biosensors are applicable to clinical diagnostics, food analysis, cell culture monitoring, environmental control and various military situations. Ever increasing demands for rapid and convenient analyses of a wide variety of materials in diverse locations has led to intense interest in the fusion of biology and electronics which mimics our principal concern: the effect of materials and environments on living systems. This series, "Advances in Biosensors", presents a compendium of research papers, in which authorities in the field of biosensors provide an up-to-date overview of their laboratory's contribution, summarizing the primary research as it has appeared, possibly scattered, in the journal and conference literature, and reflecting on their findings. The net result will be intense, yet highly readable accounts of the state of the art at this leading edge of analytical technology.
Biosensors are analytical devices that combine a biologically sensitive element with a physical or chemical transducer to selectively and quantitatively detect the presence of specific compounds. Balancing basics, principles, and case studies, Biosensors: Microelectrochemical Devices covers the theory and applications of one class of biosensor-microelectrochemical devices. The book clearly explains microelectronic techniques used to produce these cheap, fast reacting, and disposable sensors with the aid of helpful diagrams and tables. Researchers and postgraduates active in the field of chemical sensors, analytical chemistry, or microelectronics will find this an invaluable reference.
This title brings to the attention of researchers in the industry, and in academia, the application of fractals to help in modeling the analyte/receptor binding and dissociation kinetics on biosensor surfaces. The work builds on that done in Engineering Biosensors: Kinetics and Design Applications, published by Academic Press in 2002. In particular, more examples are provided of where biosensors may be effectively used. This sequel is extremely timely, given the anticipation that the applications and reliance on biosensors will increase due to the advances in miniaturization, (wireless) communications, and the development of new materials (especially biological and chemical). Other applications of biosensors on the increase can be found in: the protection of civilian structures and infrastructures; protection from possible biological and chemical threats; health care; energy; food safety; and the environment to name a few. Covers all areas of applications of biosensors No other book on biosensors describes the kinetics of binding Provides numerous examples of where biosensors may be used
A survey of the principal features of sensors based on biological materials, this text discusses the different types of biosensors and the manner in which they are connected to a range of transducers. Applications to such fields as environmental science and medicine are also considered.
Considers a new generation of sensors for use in industrial processes, which measure the chemical environment directly by means of a biological agent mainly enzymes so far. Various specialists from Europe, the US, and Japan identify the device's place in their disciplines; review the principles of m
Biosensors have emerged recently as an interesting field of research owing to a plethora of applications in our daily lives, including food and process control, environmental monitoring, defence, and clinical diagnostics.This book focuses on the state-of-the-art of biosensor research and development for specialists and non-specialists. It introduces the fundamentals of the subject with relevant characteristics of transducer elements, as well as biochemical recognition molecules.Different techniques for biomolecule immobilisation, the interaction of biomolecules with the sensor surface, and the interfacial properties are treated comprehensively with respect to their impact on the performance of a biosensor.This book presents the current trends and developments in different nanomaterials and polymers involved in biosensor fabrication. The relative advantages and challenges of biosensor fabrication, along with the emerging paradigms and techniques that facilitate molecular-level detection in nanosensor devices, are discussed in depth.
Applications to Clinical, Bioprocess, and Environmental Samples
Author: Graham Ramsay
Commercial Biosensors offers professionals an in-depth look at some of the most significant applications of commercially available biosensor-based instrumentation in the medical, bioprocess, and environmental fields. Featuring contributions by an international team of scientists, the book provides readers with an unparalleled opportunity to see how their colleagues around the world are using these powerful new tools. Commercial Biosensors is divided into three sections. In the first, which is devoted to applications of biosensors to clinical samples, the authors explore how biosensors are currently being used for in-home diabetes monitoring, point-of-care diagnostics, and noninvasive sensing, and biomedical research. The second section deals with cutting-edge applications of biosensors in bioprocess control- for example, measuring glucose, sucrose, glutamate, or choline concentrations during food and beverage production and measuring ethanol concentration during beer fermentation. In the final section, readers learn about the use of biological oxygen demand (BOD) biosensors for monitoring environmental samples. This book is an indispensable addition to the reference libraries of biosensor technologists, physicians, analytical chemists, environmental engineers, pesticide chemists, clinical chemists, and food chemists. An in-depth exploration of state-of-the-art commercial biosensor technology and its aplications. Commercial biosensor technology has taken off over the past few years, and the number of applications is growing rapidly. This book offers professionals a timely and authoritative look at some of the most important of these applications. Over the course of seven chapters authored by leading international experts, readers learn all about the latest in: * Biosensors and diabetes management * Microfabricated biosensors and point-of-care diagnostics systems * Noninvasive biosensors in clinical analysis * Surface plasmon resonance and evanescent wave biosensors * Biosensor-based instruments in food and beverage production * Biosensors in environmental sampling Commercial Biosensors is required reading for all professionals who would like to take advantage of the enormous potential of one of today's most important new commercial technologies.