Rapid prototyping is used to design and develop medical devices and instrumentation. This book details research in rapid prototyping of bio-materials for medical applications. It provides a wide variety of examples of medical applications using rapid prototyping, including tissue engineering, dental applications, and bone replacement. Coverage also discusses the emergence of computer aided design in the development of prosthetic devices.
Fatima Zivic,Saverio Affatato,Miroslav Trajanovic,Matthias Schnabelrauch,Nenad Grujovic,Kwang Leong Choy
Author: Fatima Zivic,Saverio Affatato,Miroslav Trajanovic,Matthias Schnabelrauch,Nenad Grujovic,Kwang Leong Choy
Category: Technology & Engineering
This book covers the properties of biomaterials that have found wide clinical applications, while also reviewing the state-of-the-art in the development towards future medical applications, starting with a brief introduction to the history of biomaterials used in hip arthroplasty. The book then reviews general types of biomaterials – polymers, ceramics, and metals, as well as different material structures such as porous materials and coatings and their applications – before exploring various current research trends, such as biodegradable and porous metals, shape memory alloys, bioactive biomaterials and coatings, and nanometals used in the diagnosis and therapy of cancer. In turn, the book discusses a range of methods and approaches used in connection with biomaterial properties and characterization – chemical properties, biocompatibility, in vivo behaviour characterisation, as well as genotoxicity and mutagenicity – and reviews various diagnostic techniques: histopathological analysis, imagining techniques, and methods for physicochemical and spectroscopic characterization. Properties of stent deployment procedures in cardiovascular surgeries, from aspects of prediction, development and deployment of stent geometries are presented on the basis of novel modelling approaches. The last part of the book presents the clinical applications of biomaterials, together with case studies in dentistry, knee and hip prosthesis. Reflecting the efforts of a multidisciplinary team of authors, gathering chemical engineers, medical doctors, physicists and engineers, it presents a rich blend of perspectives on the application of biomaterials in clinical practice. The book will provide clinicians with an essential review of currently available solutions in specific medical areas, also incorporating non-medical solutions and standpoints, thus offering them a broader selection of materials and implantable solutions. This work is the result of joint efforts of various academic and research institutions participating in WIMB Tempus project, 543898-TEMPUS-1-2013-1-ES-TEMPUS-JPHES, "Development of Sustainable Interrelations between Education, Research and Innovation at WBC Universities in Nanotechnologies and Advanced Materials where Innovation Means Business", co-funded by the Tempus Programme of the European Union.
3D Printing in Medicine examines the emerging market of 3D-printed biomaterials and its clinical applications. With a particular focus on both commercial and premarket tools, the book looks at their applications within medicine and the future outlook for the field. The book begins with a discussion of the fundamentals of 3D printing, including topics such as materials, and hardware. Chapters go on to cover applications within medicine such as computational analysis of 3D printed constructs, personalized 3D printing and 3D cell and organ printing. The concluding chapters in the book review the applications of 3D printing in diagnostics, drug development, 3D-printed disease models and 3D printers for surgical practice. With a strong focus on the translation of 3D printing technology to a clinical setting, this book is a valuable resource for scientists and engineers working in biomaterial, biomedical, and nanotechnology based industries and academia. Provides a comprehensive and authoritative overview of all the medical applications of 3D printing biomaterials and technologies Focuses on the emerging market of 3D printed biomaterials in clinical applications Reviews both commercial and under development materials, tools, their applications, and future evolution
Discovered in the 20th century, biomaterials have contributed to many of the incredible scientific and technological advancements made in recent decades. This book introduces and details the tenets of biomaterials, their relevance in a various fields, practical applications of their products, and potential advancements of the years to come. A comprehensive resource, the text covers the reasons that certain properties of biomaterials contribute to specific applications, and students and researchers will appreciate this exhaustive textbook.
The original role of RP was to confirm the shape and feel of concept design, but innovations in RP now allow for the development of sophisticated medical devices such as catheters, stents, drug delivery systems, syringes and cardio-vascular devices, and more. RP has moved beyond medical devices, as surgeons now regularly use RP models to brainstorm strategies for surgeries. This book presents new uses for rapid prototyping in state-of-the-art medical applications.
Rapid Prototyping of Biomaterials: Principles and Applications provides a comprehensive review of established and emerging rapid prototyping technologies (such as bioprinting) for medical applications. Rapid prototyping, also known as layer manufacturing, additive manufacturing, solid freeform fabrication, or 3D printing, can be used to create complex structures and devices for medical applications from solid, powder, or liquid precursors. Following a useful introduction, which provides an overview of the field, the book explores rapid prototyping of nanoscale biomaterials, biosensors, artificial organs, and prosthetic limbs. Further chapters consider the use of rapid prototyping technologies for the processing of viable cells, scaffolds, and tissues. With its distinguished editor and international team of renowned contributors, Rapid Prototyping of Biomaterials is a useful technical resource for scientists and researchers in the biomaterials and tissue regeneration industry, as well as in academia. Comprehensive review of established and emerging rapid prototyping technologies (such as bioprinting) for medical applications Chapters explore rapid prototyping of nanoscale biomaterials, biosensors, artificial organs, and prosthetic limbs Examines the use of rapid prototyping technologies for the processing of viable cells, scaffolds, and tissues
The Application of Advanced Design and Rapid Prototyping Techniques in Medicine
Author: Richard Bibb,Dominic Eggbeer,Abby Paterson
Publisher: Woodhead Publishing
Medical modelling and the principles of medical imaging, Computer Aided Design (CAD) and Rapid Prototyping (also known as Additive Manufacturing and 3D Printing) are important techniques relating to various disciplines - from biomaterials engineering to surgery. Building on the success of the first edition, Medical Modelling: The application of Advanced Design and Rapid Prototyping techniques in medicine provides readers with a revised edition of the original text, along with key information on innovative imaging techniques, Rapid Prototyping technologies and case studies. Following an overview of medical imaging for Rapid Prototyping, the book goes on to discuss working with medical scan data and techniques for Rapid Prototyping. In this second edition there is an extensive section of peer-reviewed case studies, describing the practical applications of advanced design technologies in surgical, prosthetic, orthotic, dental and research applications. Covers the steps towards rapid prototyping, from conception (modelling) to manufacture (manufacture) Includes a comprehensive case studies section on the practical application of computer-aided design (CAD) and rapid prototyping (RP) Provides an insight into medical imaging for rapid prototyping and working with medical scan data
Sensors, Electronics, and Integrated Power Sources
Author: Alberto Piqué,Douglas B. Chrisey
Publisher: Academic Press
Category: Technology & Engineering
Direct-Write Technologies covers applications, materials, and the techniques in using direct-write technologies. This book provides an overview of the different direct write techniques currently available, as well as a comparison between the strengths and special attributes for each of the techniques. The techniques described open the door for building prototypes and testing materials. The book also provides an overview of the state-of-the-art technology involved in this field. Basic academic researchers and industrial development engineers who pattern thin film materials will want to have this text on their shelves as a resource for specific applications. Others in this or related fields will want the book to read the introductory material summarizing isuses common to all approaches, in order to compare and contrast different techniques. Everyday applications include electronic components and sensors, especially chemical and biosensors. There is a wide range of research and development problems requiring state-of-the-art direct write tools. This book will appeal to basic researchers and development engineers in university engineering departments and at industrial and national research laboratories. This text should appeal equally well in the United States, Asia, and Europe. Both basic academic researchers and industrial development engineers who pattern thin film materials will want to have this text on their shelves as a resource for specific applications. An overview of the different direct write techniques currently available A comparison between the strengths and special attributes for each of the techniques An overview of the state-of-the-art technology involved in this field
Paul Ducheyne,Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Author: Paul Ducheyne,Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Category: Technology & Engineering
Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development
Developments in the area of biomaterials, bionanotechnology, tissue engineering, and medical devices are becoming the core of health care. Almost all medical specialties involve the use of biomaterials, and research plays a key role in the development of new and improved treatment modalities. This volume focuses on several current trends in tissue engineering, remodelling and regeneration. Leading researchers describe the use of nanomaterials to create new functionalities when interfaced with biological molecules or structures. In addition to coverage of basic science and engineering aspects, a range of applications in bionanotechnology are presented, including diagnostic devices, contrast agents, analytical tools, physical therapy applications, and vehicles for targeted drug delivery. The use of polymers, alloys, and composites, or a combination of these, for biomaterials applications in orthopaedics is also explored. These contributions represent essential reading for the biomaterials and biomedical engineering communities, and can serve as instructional course lectures targeted at graduate and post-graduate students.
are then selected and must meet the general 'biocompatibility' require ments. Prototypes are built and tested to include biocompatibility evalua tions based on ASTM standard procedures. The device is validated for sterility and freedom from pyrogens before it can be tested on animals or humans. Medical devices are classified as class I, II or III depending on their invasiveness. Class I devices can be marketed by submitting notification to the FDA. Class II and III devices require either that they show equivalence to a device marketed prior to 1976 or that they receive pre-marketing approval. The time from device conception to FDA approval can range from months (class I device) to in excess of ten years (class III device). Therefore, much planning is necessary to pick the best regulatory approach. 2. Wound Dressings and Skin Replacement 2.1 Introduction Wounds to the skin are encountered every day. Minor skin wounds cause some pain, but these wounds will heal by themselves in time. Even though many minor wounds heal effectively without scarring in the absence of treatment, they heal more rapidly if they are kept clean and moist. Devices such as Band-Aids are used to assist in wound healing. For deeper wounds, a variety of wound dressings have been developed including cell cultured artificial skin. These materials are intended to promote healing of skin damaged or removed as a result of skin grafting, ulceration, burns, cancer excision or mechanical trauma.
Focusing on a lucrative and increasingly important area of biomedicine, the Biomaterials Fabrication and Processing Handbook brings together various biomaterials production and processing aspects, including tissue engineering scaffold materials, drug delivery systems, nanobiomaterials, and biosensors. With contributions from renowned international experts and extensive reference lists in each chapter, the volume provides detailed, practical information to produce and use biomaterials. The different facets of biomaterials technology are split into four sections in the book— Part I The development of new materials and devices capable of interacting specifically with biological tissues and the preparation of scaffolds using materials with appropriate composition and structure Part II The necessary materials to create a drug delivery system capable of controlled release and the incorporation of drug reservoirs into implantable devices for sustained controlled release Part III The significant role nanotechnology plays in the biomedical and biotechnology fields Part IV More biomaterials, including synthetic and natural degradable polymeric biomaterials, electroactive polymers as smart materials, and biomaterials for gastrointestinal and cartilage repair and reconstruction
Rapid Prototyping and allied fields are still relatively young technologies and, as such, their scope and range are expanding at a dramatic rate. New and improved techniques and applicationsare developing and this is reflected in the varied topics covered in Rapid Design, Prototyping and Manufacture. Efforts to extend the scope of application of three dimensional printing processes is an important milestone in rapid manufacture. This is being vigorously addressed and is well represented in this volume. It now seems to be only a matter of time before three-dimensional printing units will join other peripherals in office and domestic computer systems to produce toys, small domestic and office items on demand. CONTENTS INCLUDE: Analysis of the application of the Z-corps three dimensional printing system for rapid tooling for plastic injection moulded components. A novel method for rapid prototyping/tooling/manufacture - Shell/Assisted Layer Manufacture (SALM) Accuracy of a novel fused deposition modelling technology New software tools for reverse engineering parts based on three-dimensional volumetric scans. A stuctured approach to the simplification of optimization problems in the virtual prototyping environment The appropriate application of computer-aided design and manufacture techniques in silicone facial prosthetics Application of the Z-Corps three-dimensional printing processes using novel material to manufacture bio-scaffold for bone replacement Rapid prototyping manufacture of complex three-dimensional microscaffolds used in regenerative medicine.
Novel Processing and Modeling Techniques for Medicine and Surgery
Author: Roger Narayan,Thomas Boland,Yuan-Shin Lee
Publisher: Springer Science & Business Media
Category: Technology & Engineering
Recent studies have shown that novel processing and modeling techniques may be used to create patient-specific prostheses, artificial tissues, and other implants using data obtained from magnetic resonance imaging, computed tomography, or other imaging techniques. For example, customized prostheses may be fabricated that possess suitable features, including geometry, size, and weight, for a given medical condition. Many advances have been made in the development of patient-specific implants in the past decade, yet this information is not readily available to scientists and students. Printed Biomaterials: Novel Processing and Modeling Techniques for Medicine and Surgery provides the biomaterials scientist and engineer, as well as advanced undergraduate or graduate students, with a comprehensive discussion of contemporary medical implant research and development. The development of printed biomaterials is multidisciplinary, and includes concepts traditionally associated with engineering, materials science, medicine, and surgery. This text highlights important topics in these core fields in order to provide the fundamentals necessary to comprehend current processing and modeling technologies and to develop new ones.
Cato T. Laurencin,Materials Research Society,Materials Research Society. Meeting
This book covers biodevices, mainly implantable or quirurgical, for the diagnosis or treatment of different pathologies, which benefit from the use of active materials as sensors or actuators. Such active or "intelligent" materials are capable of responding in a controlled way to different external physical or chemical stimuli by changing some of their properties. These materials can be used to design and develop sensors, actuators, and multifunctional systems with a large number of applications for developing biodevices and medical appliances. Current work on these fields entails problems related to synthesis, characterization, modeling, simulation, processing, and prototyping technologies, as well as device testing and validation, all of which are treated in depth in this book, for the several types of active or intelligent materials covered. The research presented in this book helps further development of medical devices, based on the additional functionalities that the use of active or "intelligent" materials, both as sensors and actuators, supplies. The main results exposed may help with the industrial expansion of this kind of materials as part of more complex systems.
Author: Ralph S. Greco,Fritz B. Prinz,R. Lane Smith
Publisher: CRC Press
Nanoscale Technology in Biological Systems reviews recent accomplishments in the field of nanobiology and introduces the application of nanoscale matrices to human biology. It focuses on the applications of nanotechnology fabrication to biomedical devices and discusses new physical methods for cell isolation and manipulation and intracellular communication at the molecular level. It also explores the application of nanobiology to cardiovascular diseases, to oncology, to transplantation and a range of related disciplines. This book build a strong background in nanotechnology and nanobiology ideal for molecular biologists, biochemists, materials scientists, bioengineers, biotechnologists
Ideal as a graduate textbook, this title is aimed at helpingdesign effective biomaterials, taking into account the complexinteractions that occur at the interface when a synthetic materialis inserted into a living system. Surface reactivity,biochemistry, substrates, cleaning, preparation, and coatingsare presented, with numerous case studies and applicationsthroughout. Highlights include: Starts with concepts and works up to real-life applicationssuch as implantable devices, medical devices, prosthetics, and drugdelivery technology Addresses surface reactivity, requirements for surface coating,cleaning and preparation techniques, and characterization Discusses the biological response to coatings Addresses biomaterial-tissue interaction Incorporates nanomechanical properties and processingstrategies
The Biomaterials Science and Engineering Series is designed to help stimulate further developments in biomaterials science and engineering by disseminating up-to-the-minute, quality information to academic and industrial research and development scientists employed in all areas of the medical, biomedical and bioengineering sciences whether in medical device R&D, pharmaceutical and pharmacological research or materials science, and to clinical specialists in prosthetics and surgery. Computer Technology in Biomaterials Science and Engineering Edited by Jos Vander Sloten, Division of Biomechanics and Engineering Design, Katholieke Universiteit Leuven, Heverlee, Belgium One of the many advances in computer technology over the past decade has been the speed and ease with which data can now be transferred and analysed. Recent developments in this particular area have been greatly beneficial to the biomaterials engineering industry. Biomaterials engineering, as defined in this book, is the scientific discipline dealing with the analysis of biological tissues and tissue-implant behaviour, in addition to the design of the foreign objects for temporary or permanent use in the body and the technology required to produce and implant them. Computer Technology in Biomaterials Science and Engineering describes how computer models and design aids have: * given insight into the fundamental mechanisms of tissue behaviour and adaptation * allowed the development of screen-based pre-surgical planning systems * facilitated the design of personalised implants at reasonable cost * aided surgical and medical robotics to assure optimal implantation in the body In addition to presenting an extensive overview of state-of-the-art computer technology and its applications in biomaterials engineering, the authors indicate future trends in this fast changing technology. Researchers in both universities and industry will find this book to be a concise reference source of computer technology in biomaterials science and engineering. Cover shows a computer-aided design image of the gradual transition from a microscopic trabecular bone structure to an engineered biomaterial scaffold. Image reproduced by the kind permission of Hans Druyts and Karel Van Brussel, Katholieke Universiteit Leuven, Heverlee, Belgium.