"A text for a one-semester course in population genetics. It introduces students to classical population genetics (in terms of allele and haplotype frequencies) and modern population genetics (in terms of coalescent theory). It presents numerous applications of population genetic methods to practical problems, including testing for natural selection, detecting genetic hitchhiking and inferring the history of populations"--Provided by publisher.
Originally published in 1970, this classic in the field of population genetics opens with elementary concepts and deals primarily with natural populations and less fully with the rather similar problems that arise in breeding livestock and cultivated plants.
Making the theory of population genetics relevant to readers, this book explains the related mathematics with a logical organization.It presents the quantitative aspects of population genetics, and employs examples of human genetics, medical evolution, human evolution, and endangered species.For an introduction to, and understanding of, population genetics.
Introductory guide to human population genetics and microevolutionary theory Providing an introduction to mathematical population genetics, Human Population Genetics gives basic background on the mechanisms of human microevolution. This text combines mathematics, biology, and anthropology and is best suited for advanced undergraduate and graduate study. Thorough and accessible, Human Population Genetics presents concepts and methods of population genetics specific to human population study, utilizing uncomplicated mathematics like high school algebra and basic concepts of probability to explain theories central to the field. By describing changes in the frequency of genetic variants from one generation to the next, this book hones in on the mathematical basis of evolutionary theory. Human Population Genetics includes: Helpful formulae for learning ease Graphs and analogies that make basic points and relate the evolutionary process to mathematical ideas Glossary terms marked in boldface within the book the first time they appear In-text citations that act as reference points for further research Exemplary case studies Topics such as Hardy-Weinberg equilibrium, inbreeding, mutation, genetic drift, natural selection, and gene flow Human Population Genetics solidifies knowledge learned in introductory biological anthropology or biology courses and makes it applicable to genetic study. NOTE: errata for the first edition can be found at the author's website: http://employees.oneonta.edu/relethjh/HPG/errata.pdf
How do plant and animal populations change genetically to evolve and adapt to their local environments? How do populations grow and interact with one another through competition and predation? How does behaviour influence ecology and evolution? Introduction to Population Biology covers all these areas and more. Taking a quantitative and Darwinian perspective, the basic theory of population processes is developed using mathematical models. To allow students of biology, ecology and evolution to gain a real understanding of the subject, key features include: • step-by-step instructions for spreadsheet simulations of many basic equations to explore the outcomes or predictions of models • worked examples showing how the equations are applied to biological questions • problem sets together with detailed solutions to help the reader test their understanding • real-life examples to help the reader relate the theory to the natural world
The Fourth Edition of Genetics of Populations is the most current, comprehensive, and accessible introduction to the field for advanced undergraduate and graduate students, and researchers in genetics, evolution, conservation, and related fields. In the past several years, interest in the application of population genetics principles to new molecular data has increased greatly, and Dr. Hedrick's new edition exemplifies his commitment to keeping pace with this dynamic area of study. Reorganized to allow students to focus more sharply on key material, the Fourth Edition integrates coverage of theoretical issues with a clear presentation of experimental population genetics and empirical data. Drawing examples from both recent and classic studies, and using a variety of organisms to illustrate the vast developments of population genetics, this text provides students and researchers with the most comprehensive resource in the field.
Author: Lyle J. Palmer,George Davey Smith,Paul R. Burton
Publisher: Policy Press
Genetic epidemiology is a field that has acquired a central role in modern biomedical science. This book provides an introduction to genetic epidemiology that begins with a primer in human molecular genetics and then examines the standard methods in population genetics and genetic epidemiology
An Introduction to Forensic Genetics is a comprehensive introduction to this fast moving area from the collection of evidence at the scene of a crime to the presentation of that evidence in a legal context. The last few years have seen significant advances in the subject and the development and application of genetics has revolutionised forensic science. This book begins with the key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field, illustrated throughout with references to relevant casework. In addition to the technology involved in generating a DNA profile, the underlying population biology and statistical interpretation are also covered. The evaluation and presentation of DNA evidence in court is discussed as well with guidance on the evaluation process and how court reports and statements should be presented. An accessible introduction to Forensic Genetics from the collection of evidence to the presentation of that evidence in a legal context Includes case studies to enhance student understanding Includes the latest developments in the field focusing on the technology used today and that which is likely to be used in the future Accessible treatment of population biology and statistics associated with forensic evidence This book offers undergraduate students of Forensic Science an accessible approach to the subject that will have direct relevance to their courses. An Introduction to Forensic Genetics is also an invaluable resource for postgraduates and practising forensic scientists looking for a good introduction to the field.
Genetic algorithms are used in science and engineering for problem solving and as computational models. This brief introduction enables readers to implement and experiment with genetic algorithms on their own. The descriptions of applications and modeling projects stretch beyond the boundaries of computer science to include systems theory, game theory, biology, ecology, and population genetics. 20 illustrations.
An Introduction to Molecular Ecology combines theoretical concepts with practice-driven examples to showcase the latest molecular and genomic techniques and their impact on the study of ecology. The opening chapters introduce the essential molecular and genetic concepts that underpin the subject and describe key molecular tools and methods available to the ecologist. Capturing the broad scope of the field, the book goes on to explore the use of molecular tools in the context of behaviouralecology, population genetics, phylogeography, conservation, and microbial ecology. The third edition includes coverage of exciting new technological and analytical developments, such as next generation sequencing, which have revolutionized the field over the last decade. Molecular ecology is now in a position to tackle some truly ecological questions for the first time since itsinception. Blending conceptual detail with the most instructive examples, An Introduction to Molecular Ecology is an ideal resource for those new to the subject needing to develop a strong working understanding of the field. Online Resource Centre: The Online Resource Centre to accompany An Introduction to Molecular Ecology features: For students: * Suggested review articles to take your learning further * Links to useful websites and software * A range of questions to consolidate your learning and understanding For registered adopters of the book: * Journal Club; suggested research papers and discussion questions linked to topics featured in the book * Figures from the textbook to view and download
Facts101 is your complete guide to An Introduction to Population Genetics , Theory and Applications. In this book, you will learn topics such as as those in your book plus much more. With key features such as key terms, people and places, Facts101 gives you all the information you need to prepare for your next exam. Our practice tests are specific to the textbook and we have designed tools to make the most of your limited study time.
This is a reprint of a classic which synthesizes population, genetics, and population genetics to form one of the first books on evolutionary ecology. Written by one of the foremost authorities in the field, it is designed as an introduction useful to readers at various levels from diverse backgrounds. It features balanced, readable coverge of both elementary and advanced topics that are essential to those interested in evolutionary biology, ecology, animal behavior, sociobiology, and paleobiology.
An Introduction to Human Molecular Genetics Second Edition Jack J. Pasternak The Second Edition of this internationally acclaimed text expandsits coverage of the molecular genetics of inherited human diseaseswith the latest research findings and discoveries. Using a unique,systems-based approach, the text offers readers a thoroughexplanation of the gene discovery process and how defective genesare linked to inherited disease states in major organ and tissuesystems. All the latest developments in functional genomics,proteomics, and microarray technology have been thoroughlyincorporated into the text. The first part of the text introduces readers to the fundamentalsof cytogenetics and Mendelian genetics. Next, techniques andstrategies for gene manipulation, mapping, and isolation areexamined. Readers will particularly appreciate the text'sexceptionally thorough and clear explanation of genetic mapping.The final part features unique coverage of the molecular geneticsof distinct biological systems, covering muscle, neurological, eye,cancer, and mitochondrial disorders. Throughout the text, helpfulfigures and diagrams illustrate and clarify complex material. Readers familiar with the first edition will recognize the text'ssame lucid and engaging style, and will find a wealth of new andexpanded material that brings them fully up to date with a currentunderstanding of the field, including: * New chapters on complex genetic disorders, genomic imprinting,and human population genetics * Expanded and fully revised section on clinical genetics, coveringdiagnostic testing, molecular screening, and varioustreatments This text is targeted at upper-level undergraduate students,graduate students, and medical students. It is also an excellentreference for researchers and physicians who need a clinicallyrelevant reference for the molecular genetics of inherited humandiseases.
Filling a unique and unmet need for introductory molecular anthropology texts, An Introduction to Molecular Anthropology covers basic genetic concepts, such as what genes are, what they do, and how they are inherited. Organized into three major sections, chapters build from basic genetic and evolutionary concepts to using genetics to make inferences about culture and molecular anthropology in the genomics age. This essential primer in genetics and molecular anthropology is suitable as a supplemental resource, a stand-alone text, and an introduction and reference for professionals.
This book aims to make population genetics approachable, logical and easily understood. To achieve these goals, the book’s design emphasizes well explained introductions to key principles and predictions. These are augmented with case studies as well as illustrations along with introductions to classical hypotheses and debates. Pedagogical features in the text include: Interact boxes that guide readers step-by-step through computer simulations using public domain software. Math boxes that fully explain mathematical derivations. Methods boxes that give insight into the use of actual genetic data. Numerous Problem boxes are integrated into the text to reinforce concepts as they are encountered. Dedicated website at www.wiley.com/go/hamiltongenetics This text also offers a highly accessible introduction to coalescent theory, the major conceptual advance in population genetics of the last two decades.
This book covers those areas of theoretical population genetics that can be investigated rigorously by elementary mathematical methods. I have tried to formulate the various models fairly generally and to state the biological as sumptions quite explicitly. I hope the choice and treatment of topics will en able the reader to understand and evaluate detailed analyses of many specific models and applications in the literature. Models in population genetics are highly idealized, often even over idealized, and their connection with observation is frequently remote. Further more, it is not practicable to measure the parameters and variables in these models with high accuracy. These regrettable circumstances amply justify the use of appropriate, lucid, and rigorous approximations in the analysis of our models, and such approximations are often illuminating even when exact solu tions are available. However, our empirical and theoretical limitations justify neither opaque, incomplete formulations nor unconvincing, inadequate analy ses, for these may produce uninterpretable, misleading, or erroneous results. Intuition is a principal source of ideas for the construction and investigation of models, but it can replace neither clear formulation nor careful analysis. Fisher (1930; 1958, pp. x, 23-24, 38) not only espoused similar ideas, but he recognized also that our concepts of intuition and rigor must evolve in time. The book is neither a review of the literature nor a compendium of results. The material is almost entirely self-contained. The first eight chapters are a thoroughly revised and greatly extended version of my published lecture notes (Nagylaki, 1977a).
In response to many requests, the Third Edition of A Primer of Population Genetics has been dramatically shortened and streamlined for greater accessibility. Designed primarily for undergraduates, it will also serve for graduate students and professionals in biology and other sciences who desire a concise but comprehensive overview of the field with a primary focus on the integration of experimental results with theory. The abundance of experimental data generated by the use of molecular methods to study genetic polymorphisms sparked a transformation in the field of population genetics. Present in virtually all organisms, molecular polymorphisms allow populations to be studied without regard to species or habitat, and without the need for controlled crosses, mutant genes, or for any prior genetic studies. Thus a familiarity with population genetics has become essential for any biologist whose work is at the population level. These fields include evolution, ecology, systematics, plant breeding, animal breeding, conservation and wildlife management, human genetics, and anthropology. Population genetics seeks to understand the causes of genetic differences within and among species, and molecular biology provides a rich repertoire of techniques for identifying these differences.